EVALUTION OF ANTIARTHRITIC ACTIVITY OF LEAF EXTRACTS OF PERGULARIA DAEMIA [FORSK] PLANT IN EXPERIMENTAL ANIMALS

  • Nitin Gulab Sutar Sanjivani College of pharmaceutical Education and research kopargaon Maharashtra 423601
  • Subodh C Pal y, NDMMVP College of Pharmacy

Abstract

Objective: Pergularia daemia [Forsk] has been used from the long time in traditional medicine. The main objective of this work is to evaluate anti-rheumatic activity of leaf of Pergularia daemia [Forsk]

Methods: Anti- arthritic activity of petroleum ether and methanol extracts of leaf of Pergularia daemia [Forsk] was evaluated by using Freund’s complete adjuvant model.

Results: Preliminary Phytochemical investigation of Petroleum ether extract of leaf of Pergularia daemia [Forsk] shows presence of steroids, terpenoids, sterols while methanolic extract of leaf of Pergularia daemia [Forsk] shows presence of alkaloids, glycosides, flavonoids, tannins and phenolic component. The petroleum ether and methanol extract of leaf of Pergularia daemia [300 mg/kg] shows an improvement in arthritis condition by reducing hind paw inflammation.

Conclusion: The methanolic extract was found to be more potent than petroleum ether extract. The result indicates that the petroleum ether and methanol extract contain such phytochemical constituents which are responsible for analgesic and anti-rheumatic activity.

 

Keywords: Perguleria daemia [Forsk] Freund’s complete adjuvant model, Methotrixate.

Downloads

Download data is not yet available.

References

1. Smolen JS, Steiner G. Therapeutic strangles for rheumatoid arthritis. Nat Rev Drug Discovery 2003;2:473-88.
2. Buch M, Emery P. The etiology and pathogenesis of rheumatoid arthritis. Hospital Pharmacist 2002;9:5-10.
3. Gabriel SE. The epdiomology of rheumatoid arthritis. Rheum Dis Clin North America 2001;27:269-82.
4. Janssen SA. Negative effect and Sensitization to pain. Scandinavian J Psychology 2002;43:131-7.
5. Calixto JB. Efficacy safety quality control marketing and regulatory guideline for herbal medicines (phytotherapetic agent). Braz J Med Biol Res 2000;33(2):179-89.
6. Khare CP. Indian Medicinal Plant (An Illustrated dictionary): Springer Science and Business Media; 2007. p. 472.
7. Kirtikar KR, Basu BD. Indian Medicinal Plants. Int Book Distrib 1999;3:1616-7.
8. Nadkarni AK. Indian materia medica. Bombay Popular Prakashan Pvt Ltd 1976;1:430.
9. Anoymous. Indian Mediccinal Plants (A Compendium of 500 species). Hydrabad: Orient Longman Ltd; 1995;4:386-9.
10. Hebbar SS, Harsha VH, Shripathi V, Hegade GR. Ethanomedicine of dharwad district in Karnataka, Indian-Plants used in oral health care. J Ethanopharmacol 2004;94:261-6.
11. Dokosi OB. Herbs of Ghana Accra; Ghana University Press; 1998, 2000.
12. Bruce TBF. Personal Communications Phytotherapists Accra. Ghana; 1998, 2000.
13. Sureshkumar SV, Mishra SH. Hepatoprotective effect of extract of Pergularia daemia Forsk. J Ethanopharmacol 2006;107:164-8.
14. Golam Sadik, Gafur MA, Shah Alam, Bhuiyan M, Khurshid Alam AHM, Heal U Biswas M, et al. Antifertility activity of Pergularia daemia Forsk. Sci 2001;a1(1):22-4.
15. Wahi AK, Ravi J Hemaltha S, Singh PN. Antidiabetic activity of Daemia extensa. J Nat Remed 2002;2(1):80-3.
16. Satish CJ, Sharma RA, Jain R, Macalo N, Capasso F, Vijayvergia R, et al. Ethanopharmacological evalution of Pergularia daemia [Forsk] Chivo. Phytother Res 1998;12:378-80.
17. Anjaneyulu ASN Raju DVSN, Srinivasa Rao S. Chemical Evalution of Pergularia daemia [Forsk]. Indian J Chem 1998;37B:318-20.
18. Khandelwal KR. Practical Pharmacognosy, Technique and Experiment.10th Edn. Nirali Prakashan: Pune, India; 2006. p. 149-56.
19. Guidelines Document on Aute Oral Toxicity Environmental Health and Safety Monograph Series on Testing and Assessment no. AOT 425.
20. Waltz DT, Martimo MJ, Misher A. Adjuvant induced Arthritis in rats: drug effect of physiologic biochemical and immunologic parameters. J Pharm 1971;178:223-31.
21. Wilder RL, Calendra GB, Gravin AJ, Wright KD, Hansen CT. Strain and sex variation in susceptibility to streptococcal cell wall-induced poly arthritis in rat. Arthritis Rheum 1982;25(9):1064-72.
22. Crofford LI, Wikder RL. Arthritis and auto immununity in animals. In; Mccarty DJ,Kopman WJ. (Edn.), Arthritis and Allied condition Lea and Febiger, London; 1993. p. 525-39.
Statistics
284 Views | 693 Downloads
How to Cite
Sutar, N. G., and S. C. Pal. “EVALUTION OF ANTIARTHRITIC ACTIVITY OF LEAF EXTRACTS OF PERGULARIA DAEMIA [FORSK] PLANT IN EXPERIMENTAL ANIMALS”. International Journal of Pharmacy and Pharmaceutical Sciences, Vol. 6, no. 10, 1, pp. 198-00, https://innovareacademics.in/journals/index.php/ijpps/article/view/2072.
Section
Original Article(s)