• Ilma Nugrahani Bandung Institute of Technology, Jl. Ganesha No.10, Kota Bandung, Jawa Barat 40132, Indonesia
  • Silvana Anggraeni Bandung Institute of Technology, Jl. Ganesha No.10, Kota Bandung, Jawa Barat 40132, Indonesia




Clindamycin HCl, Hydrate, Ethanolate, Stability


Objective: Formation of clindamycin hydrochloride (clindamycin HCl) in monohydrate-ethanolate from the recrystallization process with ethanol–water (5:2) has been reported a long time ago. However, the effect of ethanol-water compositions into pseudo-polymorphism formation and its stability of was not reported yet. This study aimed to investigate the effect of ethanol-water proportion on the formation of clindamycin HCl-monohydrate and its ethanol solvate.

Methods: Clindamycin HCl was recrystallized with the various percentages of ethanol. The fresh and after storage for 24 h at humidity and room temperature (25±2 °C, RH: 70±1%) crystals were characterized by FTIR (Fourier transform infra-red), PXRD (powder x-ray diffractometer), and DTA (differential scanning calorimeter). The study of desolvation/dehydration then was observed with a polarization microscopy-plate heater.

Results: The results showed that monohydrate crystal was obtained from recrystallization in a concentration less than 50% ethanol in water. Next, the ethanolate was produced from the solvent of>70% ethanol. Meanwhile, the 50–70 % ethanol produced a hydrate–ethanolate, crystal, which has both hydrate and ethanol in its lattice. This hydrate-ethanolates was unstable, even in ambient temperature.

Conclusion: Concentration of ethanol in water as the solvent will determine the clindamycin HCl pseudo polymorphism, which will back to its original crystal form by the time of storage.


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How to Cite

Nugrahani, I., and S. Anggraeni. “EFFECT OF ETHANOL-WATER COMPOSITION ON CLINDAMYCIN HYDROCHLORIDE PSEUDOPOLYMORPHISM”. International Journal of Pharmacy and Pharmaceutical Sciences, vol. 8, no. 11, Nov. 2016, pp. 269-74, doi:10.22159/ijpps.2016v8i11.14132.



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