ANTI-PSYCHOTIC ACTIVITY OF PYRUS COMMUNIS JUICE


Arzoo Singh Pannu, Milind Parle

Abstract


Objective: The present study aim to investigate the anti-psychotic potential of pyrus communis in the rodents.

Methods: The fresh juice of pyrus communis (Pear) was administered orally to rodents for 21 d and the anti-psychotic activity was assessed by in vitro methods viz ketamine induced stereotypic behaviour, pole climbing avoidance in rats and swim induced grooming behaviour experimental models. The biochemical estimation was done on 21 d.

Results: The different concentrations of fresh pyrus communis juice was assayed. When pyrus communis juice (PCJ) was administered chronically for 21 d remarkably decreased ketamine induced falling, head-bobbing, weaving and turning counts. Administration of Pear juice significantly delayed the latency time taken by the animals to climb the pole in Cook’s pole climb apparatus. In swim induced grooming behaviour model, Pear juice significantly reduced swim induced grooming behaviour. Moreover, Pear juice significantly decreased the brain dopamine levels and inhibited acetyl cholinesterase activity. In the present study, Pear juice significantly enhanced reduced glutathione levels in the brains of mice, thereby reflecting enhanced scavenging of free radicals and in turn preventing occurrence of psychotic attack.

Conclusion: The present study revealed that pyrus communis juice possessed significant anti-psychotic activity.


Keywords


Pear Juice, pyrus communis juice, Antioxidant, Psychosis, Dopamine

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About this article

Title

ANTI-PSYCHOTIC ACTIVITY OF PYRUS COMMUNIS JUICE

Keywords

Pear Juice, pyrus communis juice, Antioxidant, Psychosis, Dopamine

DOI

10.22159/ijpps.2017v9i4.14541

Date

27-02-2017

Additional Links

Manuscript Submission

Journal

International Journal of Pharmacy and Pharmaceutical Sciences
Vol 9, Issue 4, 2017 Page: 113-120

Online ISSN

0975-1491

Statistics

58 Views | 51 Downloads

Authors & Affiliations

Arzoo Singh Pannu
Pharmacology Division, Department of Pharm. Sciences, Guru Jambheshwar University of Science and Technology, (‘A’ Grade NAAC accredited, State Govt. University) Hisar -125001 (Haryana)
India

Milind Parle
Pharmacology Division, Department of Pharm. Sciences, Guru Jambheshwar University of Science and Technology, (‘A’ Grade NAAC accredited, State Govt. University) Hisar -125001 (Haryana)


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