NAPROXEN INDUCED ERYTHEMA MULTIFORME-A RARE CASE REPORT
Erythema multiforme (EM) is a hypersensitivity reaction characterized by varying degrees of blisters and ulcerations. We report a case of 4 y old girl child born for Non-custodial parents who has a history of seizures and a known case of carbamazepine-induced SLE (Systemic Lupus Erythematosus) when treated with anti-inflammatory drugs developed EM. The offending drug was identified and withdrawn. Steroid was given as a part of symptomatic treatment. Non-steroidal anti-inflammatory drugs (NSAIDs) are one of the most commonly prescribed groups of drugs for a variety of indications. The patient gradually improved and got discharged.
2. Erythema Multiforme: In: Dermatology Lecture notes-Cairo University. Available from: http://www.medicine.cu.edu.eg/ beta/index.php/en/departments/46-microbiology36/169-ssss44. [Last accessed on 02 Jul 2016]
3. Erythema Multiforme: In: Dermatology Lecture notes-Cairo University. Available from: http://www.medicine.cu.edu.eg/ beta/index.php/en/departments/46-microbiology36/169-ssss44. [Last accessed on 02 Jul 2016]
4. Cullen D, Bardhan KD, Eisner M. Primary gastroduodenal prophylaxis with omeprazole for non-steroidal anti-inflammatory drug users. Aliment Pharmacol Ther 1998;12:135.
5. Roujeau JC, Stern RS. Medical progress: severe adverse cutaneous reactions to drugs. N Engl J Med 1994;331:1272-85.
6. Carder RK. Hypersensitivity reactions in neonates and infants. Dermatol Ther 2005;18:160-75.
7. Farthing P, Bagan JV, Scully C. Mucosal disease series. Number IV. Erythema multiforme. Oral Dis 2005;11:261-7.
8. Zohdi-Mofi dM, Horn TD. The acrosyringeal concentration of necrotic keratinocytes in erythema multiforme: a clue to drug etiology. Clinicopathologic review of 29 cases. J Cutan Pathol 1997;24:235-40.
9. Karakaya G, Sahin S, Kalyoncu AF. Erythema multiforme: as a complication of allergen-specific immunotherapy. Allergol Immunopathol (Madr) 2001;29:276-8.
10. Prieto A, De Barrio M, PÃ©rez C, Vellosa A, Baeza ML, Herrero T. Piroxicam induced erythema multiforme. Contact Dermatitis 2005;53:263.
11. Shopf E. Skin reactions to co-trimoxazole. Infection 1987;15 Suppl 5:S254-8.
12. Katoh N, Kagawa K, Yasuno H. Piroxicam induced Stevensâ€“Johnson syndrome. J Dermatol 1995;22:677-80.
13. Hallgren J, Tengvall-Linder M, Persson M, Wahlgren CF. Stevensâ€“Johnson syndrome associated with ciprofloxacin: a review of adverse cutaneous events reported in Sweden as associated with this drug. J Am Acad Dermatol 2003;49(5 Suppl):S267-9.
14. Pise HN, Padwal SL. Diclofenac-induced angioedema: a case report. Asian J Pharm Clin Res 2015;8;4-5.
15. Campi P, Pichler WJ. Quinolone hypersensitivity. Curr Opin Allergy Clin Immunol 2003;3:275-81.
16. Gonzalez I, Lobera T, Blasco A, Del Pozo MD. Immediate hypersensitivity to quinolones; moxifl oxacin cross-reactivity. J Invest Allergol Clin Immunol 2005;15:146-9.
17. Schmid DA, Depta JPH, Pichler WJ. T cell-mediated hypersensitivity to quinolones: mechanisms and cross-reactivity. Clin Exp Allergy 2006;36:59-69.