THE EFFECTS OF PHYSICAL EXERCISE ON THE INSULIN-DEPENDENT DIABETES MELLITUS SUBJECTS USING THE MODIFIED MINIMAL MODEL

Agus Kartono; Febri Dwi Irawati; Ardian Arif Setiawan; Heriyanto Syafutra; Tony Sumaryada

doi:10.22159/ijpps.2017v9i2.15621

Authors

Agus Kartono Computational Biophysics and Molecular Modelling Research Group (CBMoRG), Department of Physics, Faculty of Mathematical and Natural Sciences, Bogor Agricultural University (IPB), Jalan Meranti, Building Wing S, 2nd Floor, Kampus IPB Dramaga, Bogor 16680, Indonesia
Febri Dwi Irawati Computational Biophysics and Molecular Modelling Research Group (CBMoRG), Department of Physics, Faculty of Mathematical and Natural Sciences, Bogor Agricultural University (IPB), Jalan Meranti, Building Wing S, 2nd Floor, Kampus IPB Dramaga, Bogor 16680, Indonesia
Ardian Arif Setiawan Computational Biophysics and Molecular Modelling Research Group (CBMoRG), Department of Physics, Faculty of Mathematical and Natural Sciences, Bogor Agricultural University (IPB), Jalan Meranti, Building Wing S, 2nd Floor, Kampus IPB Dramaga, Bogor 16680, Indonesia
Heriyanto Syafutra Computational Biophysics and Molecular Modelling Research Group (CBMoRG), Department of Physics, Faculty of Mathematical and Natural Sciences, Bogor Agricultural University (IPB), Jalan Meranti, Building Wing S, 2nd Floor, Kampus IPB Dramaga, Bogor 16680, Indonesia
Tony Sumaryada Tropical Biopharmaca Research Center, Bogor Agricultural University (IPB), Jalan Taman Kencana No. 3, Bogor 16128, Indonesia

DOI:

https://doi.org/10.22159/ijpps.2017v9i2.15621

Keywords:

Insulin-dependent diabetes mellitus, Nil, Glucose plasma, Insulin plasma, Insulin sensitivity

Abstract

Objective: In this paper, the modiï¬ed minimal model (MM) with a mathematical function for describing the insulin infusion rates was used to study of the effects of physical exercise on the dynamics of glucose and insulin on the insulin dependent diabetes mellitus (IDDM), including type 1 diabetes mellitus (T1DM) and type 2 diabetes mellitus (T2DM) subjects.

Methods: In an intravenous glucose tolerance test (IVGTT) procedure, a dose of glucose was administered intravenously to overnight-fasted subjects, 20 min after the glucose bolus, insulin was injected over 1-2 min either into the portal vein or into the femoral vein, and subsequently the glucose and insulin concentrations in plasma were frequently sampled (usually 30 times) over a period of 180 min. The dynamic glucose and insulin responses to glucose and insulin injection were analysed using the modified MM without and with physical exercise from IVGTT data.

Results: Our simulation results shown physical exercise improved blood glucose control and enhanced insulin sensitivity (S_I) index in subjects with T1DM and T2DM. However, the T1DM and T2DM subjects need to be aware of the basic strategies to prevent hypoglycemia and maintain reasonable glucose control. It should be noted that the putative improvement in exercise-induced peripheral S_I index in subjects with T1DM and T2DM was not always coincidental with the improvement of the insulin dosage.

Conclusion: The feature increased physical exercise, along with knowledge about how to modify daily insulin dosage to prevent hypoglycemia, improved blood glucose control and enhanced S_I index.Â

Downloads

Download data is not yet available.

References

Riddell MC, Iscoe KE. Physical activity, sport, and pediatric diabetes. Pediatric Diabetes 2006;7:60-70.

Marwick TH, Hordern MD, Miller T, Chyun DA, Bertoni AG, Blumenthal RS, et al. Exercise training for type 2 diabetes mellitus impact on cardiovascular risk. A scientific statement from the american heart association. Circulation 2009;119:3244-62.

Bordenave S, Brandou F, Manetta J, FeÂ´dou C, Mercier J, Brun JF. Effects of acute exercise on insulin sensitivity, glucose effectiveness and disposition index in type 2 diabetic patients. Diabetes Metabolism 2008;34:250â€“7.

Kartono A. Modiï¬ed minimal model for the effect of physical exercise on insulin sensitivity and glucose effectiveness in type 2 diabetes and healthy human. Theory Biosci 2013;132:195-206.

Vilar DA, Osifo E, Kirk M, Estevez DAG, Cerrato JC, Hockaday TDR. Influence of moderate physical exercise on insulin-mediated and non-insulin-mediated glucose uptake in healthy subjects. Metabolism 1997;46:203-9.

Derouich M, Boutayeb A. The effect of physical exercise on the dynamics of glucose and insulin. J Biomechanical 2002; 35:911-7.

Pacini G, Bergman RN. MINMOD: a computer program to calculate insulin sensitivity and pancreatic responsivity from the frequently sampled intravenous glucose tolerance test. Computer Methods Program Biomed 1986;23:113â€“22.

Boston RC, Stefanovski D, Moate PJ, Sumner AE, Watanabe RM, Bergman RN. MINMOD millennium: a computer program to calculate glucose effectiveness and insulin sensitivity from the frequently sampled intravenous glucose tolerance test. Diabetes Technol Ther 2003;5:1003-15.

Li J, Wang M, De Gaetano A, Palumbo P, Panunzi S. The range of time delay and the global stability of the equilibrium for an IVGTT model. Math Biosci 2012;235:128-37.

Leclair E, de Kerdanet M, Riddell M, Heyman E. Type 1 diabetes and physical activity in children and adolescents. J Diabetes Metab 2013;S10004:1-10.

Ludwig T, Ottinger I. Identiï¬cation of T1DM minimal model using non-consistent data from IVGTT. J Electrical Systems Information Technol 2014;1:144-9.

Katz A, Nambi SS, Mather K, Baron AD, Follmann DA, Sullivan G, et al. Quantitative insulin sensitivity check index: a simple, accurate method for assessing insulin sensitivity in humans. J Clin Endocrinal Metab 2000;85:2402-10.