ANALYSIS OF ORAL GLUCOSE TOLERANCE TEST USING MODIFIED ORAL MINIMAL MODEL TO DIAGNOSE OF TYPE 2 DIABETES

  • Dina Khairunisa SMAN 1 Dramaga, Jalan Raya Dramaga Km 7 Bogor, IndonesiSMAN 1 Dramaga, Jalan Raya Dramaga Km 7 Bogor, Indonesia, BiophysicsComputation Research Group, Physics Department, Faculty of Mathematical and Natural Sciences, Bogor Agricultural University (IPB), Kampus IPB Dramaga, Bogor 16680, Indonesiaa
  • Andari Pratiwi BiophysicsComputation Research Group, Physics Department, Faculty of Mathematical and Natural Sciences, Bogor Agricultural University (IPB), Kampus IPB Dramaga, Bogor 16680, Indonesia
  • Ardian Arif Setiawan Bogor AgricuBiophysicsComputation Research Group, Physics Department, Faculty of Mathematical and Natural Sciences, Bogor Agricultural University (IPB), Kampus IPB Dramaga, Bogor 16680, Indonesialtural University (IPB)
  • Kiagus Dahlan Bogor ABiophysicsComputation Research Group, Physics Department, Faculty of Mathematical and Natural Sciences, Bogor Agricultural University (IPB), Kampus IPB Dramaga, Bogor 16680, Indonesiagricultural University (IPB)
  • Agus Kartono Biopharmaca Research Center, Bogor Agricultural University (IPB), Jalan Taman Kencana No. 3, Bogor 16128, Indonesia

Abstract

Objective: In this paper, a mathematical model with the new insulin system for describing the modified oral minimal model of glucose plasma levels is introduced. This model is combined with non linear least-squares method is used to analyze the results of the oral glucose tolerance test (OGTT) in humans.

Methods: We used this model to analyze the published data of OGTT test to study 741 subjects, including normal glucose tolerance (NGT), impaired glucose tolerance (IGT) and type 2 diabetes mellitus (T2DM) subjects. Reducing the number of blood glucose samples needed and the duration of the tests is necessary to enhance the usability of the mathematical model. In this work, the model was to extrapolate sample data to reduce the number of samples and duration of the OGTT test.

Results: The estimated results from this model for glucose sample showed the good correlation to the reference data. The results showed that the 180 min 4glucose sample could provide a reasonable basis to enhance the use of the modified oral minimal model approach to NGT, IGT and T2DM subjects. The averaged R2 value between experimental and calculated plasma concentrations is 0.960, which indicates excellent agreement.

Conclusion: The averaged R2 value is 0.960, it indicates that a reduction in sample data is possible by using the modified oral minimal model approach to diagnosis of NGT, IGT and T2DM subjects.

Keywords: Diabetes mellitus, Mathematical model, Modified oral minimal model, Oral glucose tolerance test

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References

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How to Cite
Khairunisa, D., A. Pratiwi, A. A. Setiawan, K. Dahlan, and A. Kartono. “ANALYSIS OF ORAL GLUCOSE TOLERANCE TEST USING MODIFIED ORAL MINIMAL MODEL TO DIAGNOSE OF TYPE 2 DIABETES”. International Journal of Pharmacy and Pharmaceutical Sciences, Vol. 8, no. 8, June 2015, pp. 313-6, https://innovareacademics.in/journals/index.php/ijpps/article/view/6984.
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Original Article(s)