DIRECT SPECTROPHOTOMETRIC DETERMINATION OF ATENOLOL AND TIMOLOL ANTI-HYPERTENSIVE DRUGS


Akram M. El-didamony, Moftah A. Moustafa

Abstract


Objective: Direct and sensitive spectrophotometric method is described for the quantitative determination of some anti-hypertensive drugs such as atenolol (ATN) and timolol (TIM) in pure forms as well as in their dosage forms.

Methods: The proposed method is based on the redox reaction between the selected drugs and KMnO4 in alkaline medium. The method involves treating the aqueous solution of the selected drugs with KMnO4 in alkaline medium and measuring the bluish-green product at 610 nm. The different experimental parameters affecting the development and stability of the color were carefully studied and optimized.

Results: The fixed-time method is adopted for constructing the calibration curves, which were found to be linear over the concentration ranges of 2.0–14 mg/ml and 2.0–28 mg/ml for ATN and TIM, respectively. The determination of the studied drugs by initial rate, variable time and rate constant method was workable with the calibration equations obtained but the fixed time method has been found to be more applicable.

Conclusion: The applicability of the proposed method was demonstrated by the determination of the selected drugs in both pure and in commercial dosage forms and has met the validation requirements.


Keywords


Atenolol, Timolol, Dosage forms, Spectrophotometry, Potassium permanganate

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About this article

Title

DIRECT SPECTROPHOTOMETRIC DETERMINATION OF ATENOLOL AND TIMOLOL ANTI-HYPERTENSIVE DRUGS

Keywords

Atenolol, Timolol, Dosage forms, Spectrophotometry, Potassium permanganate

DOI

10.22159/ijpps.2017v9i3.16198

Date

03-02-2017

Additional Links

Manuscript Submission

Journal

International Journal of Pharmacy and Pharmaceutical Sciences
Vol 9, Issue 3, 2017 Page: 47-53

Online ISSN

0975-1491

Statistics

121 Views | 438 Downloads

Authors & Affiliations

Akram M. El-didamony
Chemistry Department, Faculty of Science, Zagazig University, Zagazig, 44519, Egypt
Egypt

Moftah A. Moustafa
Chemistry Department, Faculty of Science, Omar El-Moktar University, Tobruk, Libya


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