HEPATOPROTECTIVE ACTIVITY COMBINATION OF CURANGA FEL-TERRAE LOUR LEAVES AND CURCUMA HEYNEANA VALETON AND ZIJP RHIZOME IN RAT INDUCED BY COMBINATION OF RIFAMPIN AND ISONIAZID

  • Marianne . Faculty of Pharmacy, University of Sumatera Utara, Indonesia 20155
  • Jessy Chrestella Faculty of Medicine, Universitas Sumatera Utara, Padang Bulan, Medan 20155, Indonesia
  • Maria Andriani Ginting Faculty of Pharmacy, University of Sumatera Utara, Indonesia 20155
  • Aminah Dalimunthe Faculty of Pharmacy, University of Sumatera Utara, Indonesia 20155
  • Rosnani Nasution Faculty of Mathematic and Natural Sciences, Syiah Kuala, University, Banda Aceh, Indonesia 23111

Abstract

Objective: The liver is a vital organ in the body, it is often exposured to the xenobiotics that can cause injury. Pugun tano (Curanga fel-terrae) and temu giring (Curcuma heyneana) are plants that have been claimed to cure many ailments including protecting the liver. But the hepatoprotective properties of the combination of these plants has not been well studied. In this regard, the current study was undertaken to evaluate the activity combination of those plants.

Methods: The male Wistar rats were divided into 6 groups, group I was a negative control (CMC-Na); group II-IV were the treatment groups and were given combination extracts at the doses of 50 mg/kg, 75 mg/kg and 100 mg/kg respectively; group V was positive control (catechin) and group VI was normal control. All of groups except group VI were given combination rifampin 100 mg/kg and isoniazid 50 mg/kg for 15 d along with administration of extracts. At the day 16, rats were sacrificed. Histopathology of the liver and biochemical assay of blood was done at the end of the administration.

Results: The administration of the combination of C. fel-terrae and C. heyneana at the doses of 75 and 100 mg/kg significantly inhibited the elevation of aspartate aminotransferase (AST) and alanine transaminase (ALT) compared to negative control (p<0.05). Histopathological assessment of the liver was comparable to the normal control (p>0.05).

Conclusion: The combination of C. fel-terrae and C. heyneana at the dose of 75 and 100 mg/kg is able to protect the liver from damage induced by rifampin and isoniazid.

Keywords: Curanga fel-terrae, Curcuma heyneana, Hepatoprotective, Rifampin, Isoniazid

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References

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., M., J. Chrestella, M. A. Ginting, A. Dalimunthe, and R. Nasution. “HEPATOPROTECTIVE ACTIVITY COMBINATION OF CURANGA FEL-TERRAE LOUR LEAVES AND CURCUMA HEYNEANA VALETON AND ZIJP RHIZOME IN RAT INDUCED BY COMBINATION OF RIFAMPIN AND ISONIAZID”. International Journal of Pharmacy and Pharmaceutical Sciences, Vol. 9, no. 5, May 2017, pp. 23-28, doi:10.22159/ijpps.2017v9i5.16528.
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