THE STUDY OF THE ACUTE AND SUB-ACUTE ORAL TOXICITIES OF THE NEBULIZED EXTRACT OF MYRACRODRUON URUNDEUVA ALLEMÃO IN RABBITS


Islaine De Souza Salvador, Renata Da Silva Leite, Valmir Gomes De Souza, Fabricio Havy Dantas De Andrade, Rayanne Sales De A. Batista, FÁbio Santos De Souza, Rui Oliveira Macedo

Abstract


Objective: The aim of this research was to evaluate the acute and sub-acute oral toxicities of the nebulized dried extract of Myracrodruon urundeuva (NDEMU) leaf obtained by the spray drying technique on rabbits.

Methods: In the acute toxicity study, the amount of nebulized dried extract (NDE) administered was adjusted to a dose of 2000 mg/kg of leaf powder of M. urundeuva to 6 rabbits once orally and were observed for 14 days. In the sub-acute study, the amount of NDEMU administered was adjusted to a dose of 2000 mg/kg/day of to 6 rabbits once daily for 30 day, orally. The appearance of toxic symptoms was observed every day, followed by each rabbits' food and drink intake. Haematological and biochemical analysis were observed and statistical analysis was performed on them. The rabbits were killed at the end of the study, and their organs were weighed and examined before organ histology were evaluated.

Results: No toxic signs and no mortality were observed in the acute and sub-acute study. In the sub-acute study, the amount of dried extract administered was adjusted to a dose of 2000 mg/kg of leaf powder of M. urundeuva to 6 rabbits once daily for 30 days, orally. No toxic signs and no mortality were observed. There were no significant changes (p < 0.05) in the body weights, organ weights and haemato-biochemical parameters in any of the dose levels. No related histopathological lesions were observed.

Conclusion: The results indicate that the treatment of repeated doses with the dried NDEME showed low toxicity in rabbits.


Keywords


Myracrodruon urundeuva, Quercetin, Nebulized dried extract.

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About this article

Title

THE STUDY OF THE ACUTE AND SUB-ACUTE ORAL TOXICITIES OF THE NEBULIZED EXTRACT OF MYRACRODRUON URUNDEUVA ALLEMÃO IN RABBITS

Keywords

Myracrodruon urundeuva, Quercetin, Nebulized dried extract.

DOI

10.22159/ijpps.2017v9i4.16743

Date

27-02-2017

Additional Links

Manuscript Submission

Journal

International Journal of Pharmacy and Pharmaceutical Sciences
Vol 9, Issue 4, 2017 Page: 154-160

Online ISSN

0975-1491

Statistics

86 Views | 47 Downloads

Authors & Affiliations

Islaine De Souza Salvador
Departamento de Ciências Farmacêuticas, Universidade Federal da Paraíba, João Pessoa, Brazil
Brazil

Renata Da Silva Leite
Departamento de Ciências Farmacêuticas, Universidade Federal de Pernambuco, Recife, Brazil
Brazil

Valmir Gomes De Souza
Departamento de Ciências Farmacêuticas, Universidade Federal da Paraíba, João Pessoa, Brazil
Brazil

Fabricio Havy Dantas De Andrade
Departamento de Ciências Farmacêuticas, Universidade Federal de Pernambuco, Recife, Brazil
Brazil

Rayanne Sales De A. Batista
Departamento de Ciências Farmacêuticas, Universidade Federal da Paraíba, João Pessoa, Brazil
Brazil

FÁbio Santos De Souza
Departamento de Ciências Farmacêuticas, Universidade Federal da Paraíba, João Pessoa, Brazil
Brazil

Rui Oliveira Macedo
Departamento de Ciências Farmacêuticas, Universidade Federal da Paraíba, João Pessoa, Brazil
Brazil


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