DOSE-DEPENDENT AMELIORATION OF EPIGALLOCATECHIN-3-GALLATE AGAINST SODIUM VALPROATE INDUCED AUTISTIC RATS


Palanisamy Kumaravel, Gabriel Melchias, Nayagam Vasanth, Tamilarasan Manivasagam

Abstract


Objective: Autism is a neurodevelopment related disorder with a range of clinical presentations attending serious behavioral and neurological disorders among young children that now occur at epidemic rates in developing countries, India included. The objective of this research was to study the effect of epigallocatechin gallate (EGCG) on sodium valproate-induced autism rats.

Methods: On the 12th day of gestation wistar rats were administered with a single intraperitoneal injection of sodium valproate (VPA) (600 mg/kg body weight), which induced autism. The rats were treated with EGCG in varying doses 1, 2 and 5 mg/kg body weight via oral administration. The neuroprotectivity effect of the EGCG was followed by assessing the neurotransmitters and neurobiochemical activities such as serotonin, glutamate and nitrite levels in hippocampus and cerebellum region of the brain.

Results: Early prenatal exposure to VPA provokes autistic symptoms. Induction of autism significantly impinged the neurotransmitters and neurochemicals such as serotonin, glutamate and nitrite levels in the brain (hippocampus and cerebellum) increased significantly in the rats exposed to VPA. After treatment with an effective dose of EGCG 2 mg/kg body weight the neurotransmitters and neurochemicals levels were decreased when compared with control and VPA-exposed rats.

Conclusion: EGCG ameliorates and reverses autistic attributes possibly due to its neuroprotective activity which could pave the way for future investigation for the possible therapeutic approach.


Keywords


Autism, Neurotransmitters, VPA, EGCG

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About this article

Title

DOSE-DEPENDENT AMELIORATION OF EPIGALLOCATECHIN-3-GALLATE AGAINST SODIUM VALPROATE INDUCED AUTISTIC RATS

Keywords

Autism, Neurotransmitters, VPA, EGCG

DOI

10.22159/ijpps.2017v9i4.17283

Date

03-03-2017

Additional Links

Manuscript Submission

Journal

International Journal of Pharmacy and Pharmaceutical Sciences
Vol 9, Issue 4, 2017 Page: 203-206

Online ISSN

0975-1491

Statistics

22 Views | 55 Downloads

Authors & Affiliations

Palanisamy Kumaravel
Research Scholar, Department of Biotechnology, St. Joseph's College (Autonomous), Tiruchirappalli, Tamilnadu, India
India

Gabriel Melchias

Nayagam Vasanth

Tamilarasan Manivasagam

 

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