PREPARATION OF ASCORBIC ACID AND CHOLECALCIFEROL MICROSPONGES FOR TOPICAL APPLICATION


Rabia Zia, Akmal Nazir, Muhammad Kashif Iqbal Khan, Abid Aslam Maan, Ayesha Rashid

Abstract


Objective: Apart from having various physiological functions in the body, ascorbic acid (vitamin C) and cholecalciferol (vitamin D3) also have a key role in skin protection. However, their bioavailability is quite limited in the skin, and therefore, many cosmetic products are supplemented with these vitamins, which are usually associated with stability issues. To avoid these issues, here we report on the preparation of microsponges of these vitamins for topical application.

Methods: The microsponges were prepared through various emulsification-solvent evaporation methods involving single (O/O, O/W) or double (W/O/O, W/O/W, S/O/W) emulsion. The organic internal phase was consisted of Eudragit® RS 100 polymer dissolved in an organic solvent such as acetone or dichloromethane, at a constant polymer to drug ratio of 2:1. The prepared microsponges were characterized for their entrapment efficiency, droplet size and uniformity, core to wall interaction, and surface morphology.

Results: It was found that the W/O/W and S/O/W are suitable methods for the preparation of vitamin C microsponges and O/W is a suitable method for the preparation of vitamin D3 microsponges; ensuring an encapsulation efficiency of around 56-59% and 93%, respectively. The average diameter of vitamin C and D3 microsponges was typically around 56-68 μm and 48 μm, respectively.

Conclusion: It is possible to encapsulate both water and oil soluble vitamins in a microsponge system at an appreciable entrapment efficiency. The findings of the present study are expected to play a vital role in the development of cosmeceuticals.


Keywords


Microsponges, Cosmetics, Controlled release, Ascorbic acid, Cholecalciferol

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About this article

Title

PREPARATION OF ASCORBIC ACID AND CHOLECALCIFEROL MICROSPONGES FOR TOPICAL APPLICATION

Keywords

Microsponges, Cosmetics, Controlled release, Ascorbic acid, Cholecalciferol

DOI

10.22159/ijpps.2017v9i10.17525

Date

02-10-2017

Additional Links

Manuscript Submission

Journal

International Journal of Pharmacy and Pharmaceutical Sciences
Vol. 9, Issue 10, 2017 Page: 280-287

Online ISSN

0975-1491

Statistics

45 Views | 59 Downloads

Authors & Affiliations

Rabia Zia
School of Pharmaceutical Sciences, The University of Faisalabad
Pakistan

Akmal Nazir
Department of Food Engineering, University of Agriculture, Faisalabad, Pakistan
Pakistan

Muhammad Kashif Iqbal Khan
Department of Food Engineering, University of Agriculture, Faisalabad, Pakistan
Pakistan

Abid Aslam Maan
Department of Food Engineering, University of Agriculture, Faisalabad, Pakistan
Pakistan

Ayesha Rashid
School of Pharmaceutical Sciences, The University of Faisalabad
Pakistan


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