DEVELOPMENT AND VALIDATION OF DIFFERENTIAL PULSE ANODIC STRIPPING VOLTAMMETRIC ANALYSIS OF SELENIUM (IV) IN BULK AND IN DOSAGE FORMULATIONS AT A GOLD ELECTRODE MULTI-MODIFIED WITH A MIXTURE OF 3, 3′-DIAMINOBENZIDINE.4HCL AND VITAMIN E


Abdul Azizs Ramadan, Hasna Mandil, Abdulrahman Shikh-debes

Abstract


Objective: A simple, direct and very sensitive differential pulse anodic stripping voltammetric analysis (DPASVA) of selenium (IV) in bulk and in dosage formulations using a gold electrode multi-modified with a mixture of 3,3′-diaminobenzidine.4HCl (Dab) and vitamin E (VE)-Nafion (AuEMDabVEN) has been studied.

Methods: The method involves the study of various parameters (electrolyte, deposition time, pulse duration, pulse amplitude, etc.) affecting the Se(IV) determination. The proposed method was validated for specificity, linearity, precision and accuracy, repeatability, sensitivity (LOD and LOQ), robustness and solution stability with an average recovery of 98.1-100.32%.

Results: Se(IV)was determined in an aqueous HClO4 (0.2M) medium of pH 0.22 at an accumulation potential of-250 mV and an accumulation time of 200 s for CSe(IV) at 1x10-8 to 1x10-6 mol/l (0.7896-78.96 ng/ml) and 350 s for CSe(IV) at 1x10-9 to 1x10-8 mol/l (0.07896-0.7896 ng/ml) with relative standard deviations (RSD)2.4% and 4.8%, respectively.

Conclusion: This method showed very sensitive results for the determination of Se(IV) using an AuEMDabVEN than that obtained using the individual Dab or VE. This method could be applicable for the quantitative determination of the bulk Se(IV) as well as dosage formulations.


Keywords


Multi-Modified, Vitamin E, 3,3′-Diaminobenzidine.4HCl, Nafion, Se(IV), Differential pulse anodic stripping voltammetry

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References


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About this article

Title

DEVELOPMENT AND VALIDATION OF DIFFERENTIAL PULSE ANODIC STRIPPING VOLTAMMETRIC ANALYSIS OF SELENIUM (IV) IN BULK AND IN DOSAGE FORMULATIONS AT A GOLD ELECTRODE MULTI-MODIFIED WITH A MIXTURE OF 3, 3′-DIAMINOBENZIDINE.4HCL AND VITAMIN E

Keywords

Multi-Modified, Vitamin E, 3,3′-Diaminobenzidine.4HCl, Nafion, Se(IV), Differential pulse anodic stripping voltammetry

DOI

10.22159/ijpps.2017v9i7.18568

Date

01-07-2017

Additional Links

Manuscript Submission

Journal

International Journal of Pharmacy and Pharmaceutical Sciences
Vol 9, Issue 7, 2017 Page: 97-102

Online ISSN

0975-1491

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74 Views | 51 Downloads

Authors & Affiliations

Abdul Azizs Ramadan
Dept of Chemistry, Faculty of Sciences, Aleppo University, Syria
Syrian Arab Republic

Hasna Mandil
Dept of Chemistry, Faculty of Sciences, Aleppo University, Syria

Abdulrahman Shikh-debes
Dept of Chemistry, Faculty of Sciences, Aleppo University, Syria


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