THE EFFECT OF HANDING MERCURY DROP ELECTRODE ON DIFFERENTIAL PULSE POLAROGRAPHIC BEHAVIOR AND DETERMINATION OF ROSUVASTATIN IN PURE AND PHARMACEUTICAL TABLETS
Keywords:Differential pulse polarographic method, Handing mercury drop electrode, Rosuvastatin, Pharmaceutical tablets
Objective: Developing a simple, accurate and very sensitive differential pulse polarographic method (DPPM) for determination of rosuvastatin (RSV) in pure and tablets dosage forms using handing mercury drop electrode (HMDE).
Methods: The DPPM was applied in Na2HPO4 buffer at pH 1.5 using a HMDE in optimal conditions.
Results: One redaction peak was observed in the range -929 to -940 mV (Ep). The peak current Ip is linear over the ranges 0.9631-192.61 ng. mL-1; Which led to increase the sensitivity about ten and hundred times when using SMDE and DME, respectively. The relative standard deviation did not exceed 3.6% and regression analysis showed a good correlation coefficient (R2= 0.9998). The limit of detection (LOD) and the limit of quantification (LOQ) were to be 0.112 and 0.34 ng. mL-1, respectively. The amounts of RSV in different tablet dosage forms were decreases with the time (1.1-1.7% after six months at the end of the validity period).
Conclusion: The proposed method was successfully applied to determine very small amounts of RSV (0.9631 ng. mL-1) in pure form and in pharmaceutical tablets.
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