ISOXAZOLE – A POTENT PHARMACOPHORE


Krishna Veni Chikkula, Raja S.

Abstract


Isoxazole is an azole with an oxygen atom next to the nitrogen. Isoxazole rings are found in some natural products, such as ibotenic acid and also found in a number of drugs, including COX-2 inhibitor valdecoxib. Furoxan, a nitric oxide donor is containing isoxazolyl group & found in many β-lactamase resistant antibiotics, such as cloxacillin, dicloxacillin and flucloxacillin. The synthetic androgenic steroid danazol also has an isoxazole ring. The substituted isoxazoles are well developed in literature to posses significant biological activities. The disubstituted and trisubstituted isoxazoles have been reported to exhibit broad range of biological activities such as antimicrobial activity, analgesic activity, antiinflammatory activity, antioxidant activity, anticancer activity, CNS activity, antitubercular activity and miscellaneous activities like GABA agonistic activity, inhibitory activity, antihypertensive activity, and glutamate transporter activity. The present review summarizes up to date information of various biological activities of isoxazole analogs.


Keywords


Isoxazole, Antimicrobial activity, Analgesic activity, Antiinflammatory activity, Antioxidant activity, Anticancer activity, CNS activity, Antitubercular activity.

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About this article

Title

ISOXAZOLE – A POTENT PHARMACOPHORE

Keywords

Isoxazole, Antimicrobial activity, Analgesic activity, Antiinflammatory activity, Antioxidant activity, Anticancer activity, CNS activity, Antitubercular activity.

DOI

10.22159/ijpps.2017.v9i7.19097

Date

01-07-2017

Additional Links

Manuscript Submission

Journal

International Journal of Pharmacy and Pharmaceutical Sciences
Vol 9, Issue 7, 2017 Page: 13-24

Online ISSN

0975-1491

Statistics

139 Views | 78 Downloads

Authors & Affiliations

Krishna Veni Chikkula
Pharmacy Maha Vidyalaya, Secunderabad, Telangana - 500017
India

Raja S.
Department of Pharmaceutical Chemistry, GITAM Institute of Pharmacy, GITAM University, Gandhi Nagar, Rushikonda, Visakhapatnam 530045, Andhra Pradesh, India
India


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