• Alia A. Badawi Department of Pharmaceutics, Faculty of Pharmacy, Cairo University
  • Nabaweya ABD EL-Aziz Department of Pharmaceutics, Faculty of Pharmacy, 6th October University
  • Maha M. Amin Department of Pharmaceutics, Faculty of Pharmacy, Cairo University
  • Nermin M. Sheta Department of Pharmaceutics, Faculty of Pharmacy, 6th October University


Benzophenone-3, Microemulsion gel, In vitro SPF, Spreadability test, Permeation test, Sunscreen efficacy test, Microbiological UV blocking activity


Objective: Microemulsions (MEs) have been developed as active vehicles for sunscreens being physical sunscreens on their own.The aim of this study is to incorporate Benzophenone-3 (BZ-3), a chemical sunscreening agent into MEs resulting in a synergistic effect on its protective characteristics.

Methods: Screening of BZ-3 in different oils, surfactants and cosurfactants available for topical delivery was carried out. A full factorial study design (3.22) was adopted to study the effect of three independent variables namely;BZ-3, oil, and S/CoSmix(1:1) concentrations on the in-vitro SPF value of the prepared ME gel formulae.

Results: Formulae having SPF>30 were further evaluated regarding in-vitro permeation test. Finally, an in vitro microbiological assay was adopted to compare the survival percent of E.coli against UV exposure. Formula F11IPM ME gel consisting of 3% BZ-3 and 10% Isopropyl myristate as oil together with 60% w/w Tween80/Cremophore RH40 mix (1:1)as surfactant and cosurfactant respectively was chosen as the optimum formula having an in vitro SPF of 33.15±0.91,lowest permeation of 192±16.13µg/cm2 after eight hours and microbiological UV blocking activity of 88±5.84%which is not significantly different from the standard Spectra Ban plus (SPF=30) having a survival percent of 80±3.04%.

Conclusion: This study illustrated the potential use of microemulsified BZ-3 delivery system to improve the SPF of BZ-3.


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Author Biographies

Alia A. Badawi, Department of Pharmaceutics, Faculty of Pharmacy, Cairo University

Professor. Department of Pharmaceutics and Industrial Pharmacy.

Nabaweya ABD EL-Aziz, Department of Pharmaceutics, Faculty of Pharmacy, 6th October University

Professor. Department of Pharmaceutics

Maha M. Amin, Department of Pharmaceutics, Faculty of Pharmacy, Cairo University

Associate Professor. Department of Pharmaceutics and Industrial Pharmacy.

Nermin M. Sheta, Department of Pharmaceutics, Faculty of Pharmacy, 6th October University

Assisstant Lecturer, Department of Pharmaceutics


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How to Cite

Badawi, A. A., N. ABD EL-Aziz, M. M. Amin, and N. M. Sheta. “TOPICAL BENZOPHENONE-3 MICROEMULSION-BASED GELS: PREPARATION, EVALUATION AND DETERMINATION OF MICROBIOLOGICAL UV BLOCKING ACTIVITY”. International Journal of Pharmacy and Pharmaceutical Sciences, vol. 6, no. 8, Aug. 2014, pp. 562-70,



Original Article(s)