USE OF CASHEW BARK EXUDATE GUM IN THE PREPARATION OF 4 % LIDOCAINE HCL TOPICAL GELS
Objective: The objective of the current work was to prepare and evaluate ex vivo skin permeation of cashew bark exudate gum based 4 % lidocaine HCl topical gels.
Methods: In the current work, 4 % lidocaine HCl topical gels were prepared by using different concentrations of cashew bark exudate gum, HPMC K4M, lidocaine HCl, methyl paraben (as preservative) and glycerin (as plasticizer). The formulated topical gels were evaluated for pH, viscosity, and ex vivo skin permeation through excised porcine ear skin membrane.
Results: The pHs of these formulated 4 % lidocaine HCl topical gels were found within the range of 6.04Â±0.02 to 6.52Â±0.04; whereas, the viscosities were measured within the range, 4.38Â±0.02 x 106to 4.74Â±0.04 x 106 cps. Sustained ex vivo permeation of lidocaine was measured over 7 h. Highest ex vivo permeation flux was measured when 0.1 % menthol was incorporated as a permeation enhancer. It was also higher than that of the marketed 4 % lidocaine HCl topical gel. The stability study by freeze thaw cycle method revealed physically stable gels without the occurrence of syneresis.Conclusion: The results clearly indicate a promising potential of the use of cashew bark exudate gum as a gelling material with HPMC K4M to prepare 4 % lidocaine HCl topical gels of good skin permeation capability
2. Das B, Sen SO, Maji R, Nayak AK, Sen KK. Transferosomal gel for transdermal delivery of risperidone. J Drug Delivery Sci Technol 2017;38:59-71.
3. Malakar J, Basu A, Nayak AK. Candesartan cilexetil microemulsions for transdermal delivery: formulation, in vitro skin permeation and stability assessment. Curr Drug Delivery 2014;11:313-21.
4. Das S, Samanta A, Bose A. Design, development and evaluation of fluconazole topical gels. Asian J Pharm Clin Res 2015;8:199-206.
5. Kaur D, Raina A, Singh N. Formulation and evaluation of Carbopol 940 based glibenclamide transdermal gel. Int J Pharm Pharm Sci 2014;6:434-40.
6. Jana S, Ali SA, Nayak AK, Sen KK, Basu SK. Development and optimisation of a topical gel containing aceclofenac-crospovidone solid dispersion by â€œQuality by Designâ€ approach. Chem Eng Res Des 2014;92:2095-105.
7. Verma A. Formulation and evaluation of clobetasol proprionate gel. Asian J Pharm Clin Res 2013;6:15-8.
8. Nayak AK, Mohanty B, Sen KK. Comparative evaluation of in vitro diclofenac sodium permeability across excised mouse skin from different common pharmaceutical vehicles. Int J PharmTech Res 2010;2:920-30.
9. Jana S, Manna S, Nayak AK, Sen KK, Basu SK. Carbopol gel containing chitosan-egg albumin nanoparticles for transdermal aceclofenac delivery. Colloids Surf B 2014;114;36-44.
10. Abdelgawad R, Nasr M, Hamza MY, Awad GAS. Topical and systemic dermal carriers for psoriasis. Int J Curr Pharm Res 2016;8:4-9.
11. Pithayanukul P, Chansri N, Sugibayashi K. The enhancing effects of common pharmaceutical solvents on the in vitro skin permeation of estradiol. Thai J Pharm Sci 2002;26:109-19.
12. Reiz GME, Reiz SL. EMLAâ€“a eutectic mixture of local anaesthetics for topical anaesthesia. Acta Anaesthesiol Scand 1982;26:596â€“8.
13. Wang Y, Su W, Li Q, Li C, Wang H, Li Y, et al. Preparation and evaluation of lidocaine hydrochloride-loaded TAT-conjugated polymeric liposomes for transdermal delivery. Int J Pharm 2013;441:748-56.
14. Trotta M, Peira E, Debernardi F, Gallarate M. Elastic liposomes for skin delivery of dipotassium glycyrrhizinate. Int J Pharm 2002;241:319â€“27.
15. Smith DW, Peterson MR, DeBerard SC. Regional anaesthesia. Nerve blocks of the extremities and face. Postgrad Med 1999;106:57â€“60.
16. Lee PJ, Ahamad N, Langer R, Mitragotri S, Shastri VP. Evaluation of chemical enhancers in the transdermal delivery of lidocaine. Int J Pharm 2006;308:33-9.
17. Sarpotdar PP, Zatz JL. Evaluation of penetration enhancement of lidocaine by nonionic surfactants through hairless mouse skin in vitro. J Pharm Sci 1986;75:176â€“81.
18. Shin SC, Cho CW, Yang KH. Development of lidocaine gels for enhanced local anesthetic action. Int J Pharm 2004;287:73â€“8.
19. Mueller-Goymann CC, Frank SG. Interaction of lidocaine and lidocaine-HCl with liquid crystal structure of topical preparations. Int J Pharm 1986;29:147-59.
20. Padula C, S Nicoli S, Colombo P, Santi P. Single-layer transdermal film containing lidocaine: modulation of drug release. Eur J Pharm Biopharm 2007;66:422-8.
21. Rowbotham MC, Davies PS, Fields HL. Topical lidocaine gel reduces pain in post-herpetic neuralgia. Ann Neurol 1995; 37:246-53.
22. Das B, Nayak AK, Nanda U. Topical gels of lidocaine HCl using cashew gum and Carbopol 940:Preparation and in vitro skin permeation. Int J Biol Macromol 2013;62:514-7.
23. De Paula RCM, Rodrigues JF. Composition and rheological properties of cashew tree gum, the exudate polysaccharide from Anacardium occidentale L. Carbohydr Polym 1995;26:177â€“81.
24. Das B, Dutta S, Nayak AK, Nanda U. Zinc alginate-carboxy-methyl cashew gum micro beads for prolonged drug release: development and optimization. Int J Biol Macromol 2014;70:505-15.
25. Silva DA, de Paula RCM, Feitosa JPA, de Brito ACF, Maciel JS, Paula HCB. Carboxymethylation of cashew tree exudate polysaccharide. Carbohydr Polym 2004;58:163â€“71.
26. Silva DA, Feitosa JPA, Maciel JS, Paula HCB, de Paula RCM. Characterization of crosslinked cashew gum derivatives. Carbohydr Polym 2006;66:16â€“26.
27. Gowthamarajan K, Phani Kumar GK, Gaikward NB, Suresh B. Preliminary study of Anacardium occidentale gum as a binder in the formulation of paracetamol tablets. Carbohydr Polym 2011;83:506-11.
28. Gowthamarajan K, Jawahar N, Wake P, Jain K, Sood S. Development of buccal tablets for curcumin using Anacardium occidentale gum. Carbohydr Polym 2012;88:1177â€“83.
29. Kumar R, Patil MB, Patil SR, Paschapur MS. Evaluation of Anacardium occidentale gum as gelling agent in aceclofenac gel. Int J PharmTech Res 2009;1:695-704.
30. Malakar J, Sen SO, Nayak AK, Sen KK. Development and evaluation of microemulsions for transdermal delivery of insulin. ISRN Pharm 2011. http://dx.doi.org/10.5402/ 2011/780150
31. Malakar J, Nayak AK, Basu A. Ondansetron HCl microemulsions for transdermal delivery: Formulation and in vitro evaluation. ISRN Pharm 2012. http://dx.doi.org/10.5402/2012/428396
32. Rath Adhikari SN, Nayak BS, Nayak AK, Mohanty B. Formulation and evaluation of buccal patches for delivery of atenolol. AAPS PharmSciTech 2010;11:1034-44.
33. Malakar J, Sen SO, Nayak AK, Sen KK. Formulation, optimisation and evaluation of transpersonal gel for transdermal insulin delivery. Saudi Pharm J 2012;20:355-63.
34. Panda D, Si S, Swain S, Kanungo SK, Gupta R. Preparation and evaluation of gels from the gum of Moringa oleifera. Indian J Pharm Sci 2006;68:777-80.
35. Pathan IB, Setty CM. Chemical penetration enhancers for transdermal drug delivery systems. Trop J Pharm Res 2009;8:173-9.
36. Jain AK, Thomas NS, Panchangnula R. Transdermal drug delivery of imipramine hydrochloride. I. Effect of terpenes. J Controlled Release 2002;79:93-101.