USE OF CASHEW BARK EXUDATE GUM IN THE PREPARATION OF 4 % LIDOCAINE HCL TOPICAL GELS


M. Saquib Hasnain, Poonam Rishishwar, Sadath Ali

Abstract


Objective: The objective of the current work was to prepare and evaluate ex vivo skin permeation of cashew bark exudate gum based 4 % lidocaine HCl topical gels.

Methods: In the current work, 4 % lidocaine HCl topical gels were prepared by using different concentrations of cashew bark exudate gum, HPMC K4M, lidocaine HCl, methyl paraben (as preservative) and glycerin (as plasticizer). The formulated topical gels were evaluated for pH, viscosity, and ex vivo skin permeation through excised porcine ear skin membrane.

Results: The pHs of these formulated 4 % lidocaine HCl topical gels were found within the range of 6.04±0.02 to 6.52±0.04; whereas, the viscosities were measured within the range, 4.38±0.02 x 106to 4.74±0.04 x 106 cps. Sustained ex vivo permeation of lidocaine was measured over 7 h. Highest ex vivo permeation flux was measured when 0.1 % menthol was incorporated as a permeation enhancer. It was also higher than that of the marketed 4 % lidocaine HCl topical gel. The stability study by freeze thaw cycle method revealed physically stable gels without the occurrence of syneresis.

Conclusion: The results clearly indicate a promising potential of the use of cashew bark exudate gum as a gelling material with HPMC K4M to prepare 4 % lidocaine HCl topical gels of good skin permeation capability

Keywords


Cashew bark exudate gum, Gel, Lidocaine HCl, Skin permeation, Topical application

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About this article

Title

USE OF CASHEW BARK EXUDATE GUM IN THE PREPARATION OF 4 % LIDOCAINE HCL TOPICAL GELS

Keywords

Cashew bark exudate gum, Gel, Lidocaine HCl, Skin permeation, Topical application

DOI

10.22159/ijpps.2017v9i8.19815

Date

01-08-2017

Additional Links

Manuscript Submission

Journal

International Journal of Pharmacy and Pharmaceutical Sciences
Vol 9, Issue 8, 2017 Page: 146-150

Online ISSN

0975-1491

Statistics

19 Views | 65 Downloads

Authors & Affiliations

M. Saquib Hasnain
Department of Pharmacy, Shri Venkateshwara University, NH-24, Rajabpur, Gajraula, Amroha – 244236, U.P., India
India

Poonam Rishishwar
Department of Pharmacy, Shri Venkateshwara University, NH-24, Rajabpur, Gajraula, Amroha – 244236, U.P., India
India

Sadath Ali
Department of Pharmacy, Glocal University, Saharanpur-247001,U.P., India.


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