PREPARATION AND EVALUATION OF CO-CRYSTALS OF CARBAMAZEPINE WITH GLUCOMANNAN

  • Sharwaree Hardikar Department of Pharmaceutics, Pune District Education Association’s Seth Govind Raghunath Sable College of Pharmacy, Saswad. District– Pune, Maharashtra- 412301 India
  • Ashok Bhosale Department of Pharmaceutics, Pune District Education Association’s Seth Govind Raghunath Sable College of Pharmacy, Saswad, District– Pune, Maharashtra- 412301 India
  • Swati Vanave Department of Pharmaceutics, Pune District Education Association’s Seth Govind Raghunath Sable College of Pharmacy, Saswad, District– Pune, Maharashtra- 412301 India
  • Bhagyashree Kamathe Department of Pharmaceutics, Pune District Education Association’s Seth Govind Raghunath Sable College of Pharmacy, Saswad, District– Pune, Maharashtra- 412301 India

Abstract

Objective: The objective of the present work was to inhibit transformation of carbamazepine anhydrous to its dihydrate form in aqueous medium by adopting the co-crystal approach.

Methods: Co-crystallization of carbamazepine and glucomannan as co-former was carried out by solution mediated phase transformation. The solution of carbamazepine and glucomannan in ethanol (95%) was agitated for 2 h and the co-crystals obtained were recovered after 24 h.

Results: Co-crystal formation due to hydrogen bonding between carbamazepine and glucomannan as a co-former was confirmed by FTIR study. Inhibition of transformation of co-crystal of carbamazepine to carbamazepine dihydrate in aqueous medium was confirmed by SEM.

Conclusion: Inhibition of transformation of carbamazepine co-crystal to its dihydrate form resulted in its improved dissolution. Dissolution efficiency of carbamazepine in its co-crystal was increased up to 79.26% within 30 min.

Keywords: Carbamazepine, Co-crystals, Glucomannan, Ocimum basilicum

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How to Cite
Hardikar, S., A. Bhosale, S. Vanave, and B. Kamathe. “PREPARATION AND EVALUATION OF CO-CRYSTALS OF CARBAMAZEPINE WITH GLUCOMANNAN”. International Journal of Pharmacy and Pharmaceutical Sciences, Vol. 9, no. 10, Oct. 2017, pp. 318-20, doi:10.22159/ijpps.2017v9i10.20656.
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