PREPARATION AND EVALUATION OF CO-CRYSTALS OF CARBAMAZEPINE WITH GLUCOMANNAN


Sharwaree Hardikar, Ashok Bhosale, Swati Vanave, Bhagyashree Kamathe

Abstract


Objective: The objective of the present work was to inhibit transformation of carbamazepine anhydrous to its dihydrate form in aqueous medium by adopting the co-crystal approach.

Methods: Co-crystallization of carbamazepine and glucomannan as co-former was carried out by solution mediated phase transformation. The solution of carbamazepine and glucomannan in ethanol (95%) was agitated for 2 h and the co-crystals obtained were recovered after 24 h.

Results: Co-crystal formation due to hydrogen bonding between carbamazepine and glucomannan as a co-former was confirmed by FTIR study. Inhibition of transformation of co-crystal of carbamazepine to carbamazepine dihydrate in aqueous medium was confirmed by SEM.

Conclusion: Inhibition of transformation of carbamazepine co-crystal to its dihydrate form resulted in its improved dissolution. Dissolution efficiency of carbamazepine in its co-crystal was increased up to 79.26% within 30 min.


Keywords


Carbamazepine, Co-crystals, Glucomannan, Ocimum basilicum

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About this article

Title

PREPARATION AND EVALUATION OF CO-CRYSTALS OF CARBAMAZEPINE WITH GLUCOMANNAN

Keywords

Carbamazepine, Co-crystals, Glucomannan, Ocimum basilicum

DOI

10.22159/ijpps.2017v9i10.20656

Date

02-10-2017

Additional Links

Manuscript Submission

Journal

International Journal of Pharmacy and Pharmaceutical Sciences
Vol. 9, Issue 10, 2017 Page: 318-320

Online ISSN

0975-1491

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Authors & Affiliations

Sharwaree Hardikar
Department of Pharmaceutics, Pune District Education Association’s Seth Govind Raghunath Sable College of Pharmacy, Saswad. District– Pune, Maharashtra- 412301 India
India

Ashok Bhosale
Department of Pharmaceutics, Pune District Education Association’s Seth Govind Raghunath Sable College of Pharmacy, Saswad, District– Pune, Maharashtra- 412301 India

Swati Vanave
Department of Pharmaceutics, Pune District Education Association’s Seth Govind Raghunath Sable College of Pharmacy, Saswad, District– Pune, Maharashtra- 412301 India

Bhagyashree Kamathe
Department of Pharmaceutics, Pune District Education Association’s Seth Govind Raghunath Sable College of Pharmacy, Saswad, District– Pune, Maharashtra- 412301 India


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