• KANCHAN JAMKAR Department of Pharmaceutics, SGRS College of Pharmacy, Saswad Pune
  • SWATI MUTHA Department of Pharmaceutics, SGRS College of Pharmacy, Saswad Pune
  • SHARWAREE HARDIKAR Department of Pharmaceutics, Allana College of Pharmacy, Pune
  • NIKHIL KUMBHAR Department of Pharmaceutics, Allana College of Pharmacy, Pune


Objective: To develop and evaluate the mucoadhesive microsphere using combinations of natural polymers chitosan and xanthan gum for sustained release.

Methods: In the present work mucoadhesive microspheres were prepared by using natural polymers like chitosan and xanthan gum by using the emulsion chemical cross-linking method. Chemical cross-linking was done by using glutaraldehyde. The 22 factorial design was employed to show the effect of cross-linking agent and processing factor-like stirring and speed. Prepared microspheres were evaluated for their particle size, surface morphology, drug entrapment efficiency, in vitro drug release, swelling index, and mucoadhesive strength.

Results: The size of microspheres of factorial batches were in the range of 26-46 µm. The swelling index was showed in the range of 1.51-1.66 percentage. The equation of multiple regression revealed that there was significant interaction among factors. The glutaraldehyde concentration had a positive effect on % entrapment efficiency, % cumulative drug release and % mucoadhesion. Stirring speed showed a negative impact on % entrapment efficiency, % cumulative drug release and % mucoadhesion. The interactive effect of glutaraldehyde concentration and the stirring speed was found to be positive for % entrapment efficiency and % cumulative drug release. In vitro drug release study of optimized formulation F2 show 96 % of drug release with 6 h indicating sustained release behavior with diffusion mechanism. The SEM image of the optimized batch was spherical with a porous surface.

Conclusion: The results obtained in this research work indicated that a promising potential of chitosan and xanthan gum combination for the preparation of the mucoadhesive microsphere of Racecadotril.

Keywords: Chitosan, Xanthan gum, Racecadotril, Mucoadhesive microsphere, Natural polymer


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How to Cite
JAMKAR, K., S. MUTHA, S. HARDIKAR, and N. KUMBHAR. “FORMULATION AND EVALUATION OF RACECADOTRIL MUCOADHESIVE MICROSPHERES”. International Journal of Pharmacy and Pharmaceutical Sciences, Vol. 12, no. 2, Dec. 2019, pp. 55-61, doi:10.22159/ijpps.2020v12i2.36060.
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