FORMULATION AND EVALUATION OF RACECADOTRIL MUCOADHESIVE MICROSPHERES

  • KANCHAN JAMKAR Department of Pharmaceutics, SGRS College of Pharmacy, Saswad Pune
  • SWATI MUTHA Department of Pharmaceutics, SGRS College of Pharmacy, Saswad Pune
  • SHARWAREE HARDIKAR Department of Pharmaceutics, Allana College of Pharmacy, Pune
  • NIKHIL KUMBHAR Department of Pharmaceutics, Allana College of Pharmacy, Pune

Abstract

Objective: To develop and evaluate the mucoadhesive microsphere using combinations of natural polymers chitosan and xanthan gum for sustained release.


Methods: In the present work mucoadhesive microspheres were prepared by using natural polymers like chitosan and xanthan gum by using the emulsion chemical cross-linking method. Chemical cross-linking was done by using glutaraldehyde. The 22 factorial design was employed to show the effect of cross-linking agent and processing factor-like stirring and speed. Prepared microspheres were evaluated for their particle size, surface morphology, drug entrapment efficiency, in vitro drug release, swelling index, and mucoadhesive strength.


Results: The size of microspheres of factorial batches were in the range of 26-46 µm. The swelling index was showed in the range of 1.51-1.66 percentage. The equation of multiple regression revealed that there was significant interaction among factors. The glutaraldehyde concentration had a positive effect on % entrapment efficiency, % cumulative drug release and % mucoadhesion. Stirring speed showed a negative impact on % entrapment efficiency, % cumulative drug release and % mucoadhesion. The interactive effect of glutaraldehyde concentration and the stirring speed was found to be positive for % entrapment efficiency and % cumulative drug release. In vitro drug release study of optimized formulation F2 show 96 % of drug release with 6 h indicating sustained release behavior with diffusion mechanism. The SEM image of the optimized batch was spherical with a porous surface.


Conclusion: The results obtained in this research work indicated that a promising potential of chitosan and xanthan gum combination for the preparation of the mucoadhesive microsphere of Racecadotril.

Keywords: Chitosan, Xanthan gum, Racecadotril, Mucoadhesive microsphere, Natural polymer

Downloads

Download data is not yet available.

References

1. Shailesh L, Mahesh K. Controlled release approach to novel multiparticulate drug delivery system. Int J Pharm Pharm Sci 2012;4:757-63.
2. Dey NS, Majumdar S. Multiparticulates drug delivery system for controlled release. Trop J Pharm Res 2008;7:1067-75.
3. Ravindra B, Yogesh Y, Nilesh P, Jaiprakash V, Potdar B. Bioadhesive multiparticulate (Microsphere) drug delivery system. J Drug Delivery Ther 2013;3:176-85.
4. Vikram K Sahu, Nitin Sharma, Pratap K Sahu. Shushing a saraf formulation and evaluation of floating-mucoadhesive microspheres of novel natural polysaccharide for site-specific delivery of ranitidine hydrochloride. Int J Appl Pharm 2017;9:15-9.
5. Hemlata K, Harikumar L, Amanpreet K. Mucoadhesive microsphere as the carrier in drug delivery: a review. Int J Drug Dev Res 2012;4:21-3.
6. Indian Pharmacopoeia, Government of India, Ministry of health and family welfare. Vol. 1. Published by the controller of publication, The Indian Pharmacopoeia commission Ghaziabad; 2014. p. 2633-5.
7. Martin G, Berry D, Brown B. Preparation and evaluation of the in vitro drug release properties and mucoadhesion of novel microsphere of hyaluronic acid and chitosan. JCR 2000;6:281-92.
8. Tank K. Development of a new analytical method for quantitative estimation of racecadotril as an active pharmaceutical ingredient by UV spectrophotometer. Int J Pharm Sci Res 2012;3:1495-7.
9. Raymond C, Paul J, Sian C. Owen 6th edition, Handbook of Pharmaceutical Excipients. Published by the Pharmaceutical Press 2009;314:564-74.
10. Sellappan V, Ali A. Formulation and evaluation of ritonavir mucoadhesive microspheres. J Chem Pharm Res 2014;6:952-60.
11. Pawan C, Sanjay S, Anil B, Akanksha G. Bioadhesive microsphere: a review. World J Pharm Res 2015;4:2277-7105.
12. Sandeep K, Nanda A. Formulation, optimization and in vitro evaluation of the gastroretentive mucoadhesive microsphere of furosemide. Int J Pharm Pharm Sci 2016;8:392-8.
13. Nirav P, Dhagesh A, Praful D, Vikram P. Microsphere as novel drug delivery. Int J Pharm Life Sci 2011;2:992-7.
14. Sarrita T, Anna B, Jaswanth A. Design and evaluation of forskolin buccal mucoadhesive microsphere. Int J Curr Pharm Res 2015;7:17-21.
15. Jadhav S, Sharma Y. Mucoadhesive microsphere. Indo Am J Pharm Res 2015;5:2231-6876.
16. Navneet V, Pronobesh C. In vitro and in vivo evaluation of mucoadhesive patches containing metoprolol succinates. Asian J Pharm Clin Res 2014;7:47-52.
17. Pawan C, Sanjay S, Anil B, Akanksha G. Bioadhesive microsphere: a review. World J Pharm Res 2015;4:2277-7105.
18. E Chandra Sekhar, KSV Krishna Rao, R Ramesh Raju. Chitosan/guar gum-g-acrylamide semi IPN microspheres for controlled release studies of 5-Fluorouracil. J Appl Pharm Sci 2011;1:199-204.
Statistics
56 Views | 63 Downloads
Citatons
How to Cite
JAMKAR, K., S. MUTHA, S. HARDIKAR, and N. KUMBHAR. “FORMULATION AND EVALUATION OF RACECADOTRIL MUCOADHESIVE MICROSPHERES”. International Journal of Pharmacy and Pharmaceutical Sciences, Vol. 12, no. 2, Dec. 2019, pp. 55-61, doi:10.22159/ijpps.2020v12i2.36060.
Section
Original Article(s)