EXPLORING STRUCTURAL ASPECTS OF NATEGLINIDE POLYMORPHS USING POWDER X-RAY DIFFRACTION


Parnika Goyal, Dimpy Rani, Renu Chadha

Abstract


Objective: The present manuscript highlights the structural aspects of some polymorphic forms of nateglinide using powder x-ray diffraction (PXRD) pattern.

Methods: All the polymorphic forms were isolated as microcrystalline powder, therefore, powder diffraction patterns was used as a tool to determine the crystal structure. For this, Reflux Plus module of BIOVIA Material Studio software was used. Polymorph prediction (PP) and crystal morphology analysis were performed to estimate the global minimum in lattice energy landscape and morphologically important (M. I.) facets, respectively. Besides this, to investigate the behavior of polymorphs in solution phase, in vitro studies (enthalpy of solution, solubility, intrinsic dissolution rate) were also performed.

Results: A new form MS was prepared and characterized. The Form H, B, MS and S were found to exist in space group P-1, C2, P-4 and P-42C, respectively. These crystal structures were found to lie on local minima in crystal energy landscape. The stability ranking of nateglinide polymorphs follows the order: Form MS<Form B<Form H<Form S.

Conclusion: This research work demonstrates that PXRD is a valuable alternative for determining the structure of microcrystalline powders.


Keywords


Nateglinide, Powder diffraction pattern, Crystal structure, Polymorph prediction, Crystal energy landscape, Crystal morphology

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About this article

Title

EXPLORING STRUCTURAL ASPECTS OF NATEGLINIDE POLYMORPHS USING POWDER X-RAY DIFFRACTION

Keywords

Nateglinide, Powder diffraction pattern, Crystal structure, Polymorph prediction, Crystal energy landscape, Crystal morphology

DOI

10.22159/ijpps.2017v9i10.20795

Date

02-10-2017

Additional Links

Manuscript Submission

Journal

International Journal of Pharmacy and Pharmaceutical Sciences
Vol. 9, Issue 10, 2017 Page: 119-127

Online ISSN

0975-1491

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Authors & Affiliations

Parnika Goyal
University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh-160014
India

Dimpy Rani
University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh-160014
India

Renu Chadha
University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh-160014
India


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