MALONDIALDEHYDE, ADIPONECTIN, NITRIC OXIDE, C-REACTIVE PROTEIN, TUMOR NECROSIS FACTOR-ALPHA AND INSULIN RESISTANCE RELATIONSHIPS AND INTER-RELATIONSHIPS IN TYPE 2 DIABETES EARLY STAGE IS METFORMIN ALONE ADEQUATE IN THIS STAGE


Entsar A Saad, Salem A. Habib, Wael A. Refai, Amira A. Elfayoumy

Abstract


Objective: Great interest is directed to inflammation and oxidative stress involvement in type 2 diabetes pathogenesis. Many researchers suggest they play roles but exactly how is still not clear enough. This encouraged us to investigate relations and potential inter-relationships between them and insulin resistance in type 2 diabetes in its early stage. Whether metformin drug alone, as frequently prescribed, is enough for type 2 diabetes management in this early stage was an objective.Methods: Blood sugar indices, adiponectin (ADIPOQ), tumor necrosis factor-α (TNF-α), malondialdehyde (MDA), nitric oxide (NO), C-reactive protein (CRP), liver and kidney function tests and lipid profile were monitored in non-diabetic volunteers, pre-diabetic and newly diagnosed type 2 diabetic patients before and after metformin drug utilization for 5 mo.Results: MDA, inflammation markers and alanine aminotransferase (ALT) were elevated, and blood sugar indices and lipid profile showed pathological alterations in diabetics compared to non-diabetics; changes were worse in type 2 cases. They were improved to different degrees by metformin treatment except for pancreatic β-cells function and ADIPOQ level showed no significant improvements and it couldn’t normalize ALT.Conclusion: Results reflected significant relations and inter-relationships between oxidative stress and inflammation markers in type 2 diabetes in its early stage and indicated that metformin may need to be combined with another drug. 

Keywords


Free radicals, Lipid peroxidation, Oxidative stress, Inflammation, Pre-diabetes, Metformin

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About this article

Title

MALONDIALDEHYDE, ADIPONECTIN, NITRIC OXIDE, C-REACTIVE PROTEIN, TUMOR NECROSIS FACTOR-ALPHA AND INSULIN RESISTANCE RELATIONSHIPS AND INTER-RELATIONSHIPS IN TYPE 2 DIABETES EARLY STAGE IS METFORMIN ALONE ADEQUATE IN THIS STAGE

Keywords

Free radicals, Lipid peroxidation, Oxidative stress, Inflammation, Pre-diabetes, Metformin

DOI

10.22159/ijpps.2017v9i10.21149

Date

02-10-2017

Additional Links

Manuscript Submission

Journal

International Journal of Pharmacy and Pharmaceutical Sciences
Vol. 9, Issue 10, 2017 Page: 176-181

Online ISSN

0975-1491

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Authors & Affiliations

Entsar A Saad
Chemistry Department, Faculty of Science, Damietta University, Damietta, Egypt
Egypt

Salem A. Habib
Department of Biochemistry, Faculty of Science, University of Tabuk, Saudi Arabia
Egypt

Wael A. Refai
Internal Medicine Department, Medical Research Institute, Alexandria University, Alexandria, Egypt
Egypt

Amira A. Elfayoumy
Chemistry Department, Faculty of Science, Damietta University, Damietta, Egypt
Egypt


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