ANTIHYPERGLYCEMIC ACTIVITY OF PHENYL AND ORTHO-HYDROXY PHENYL LINKED IMIDAZOLYL TRIAZOLO HYDROXAMIC ACID DERIVATIVES
Objective: The paradigm was to establish phenyl and ortho-hydroxy phenyl linked imidazolyl triazolo hydroxamic acid derivatives as an antihyperglycemic agent.
Methods: 100 mg/Kg body weight dose of phenyl and ortho-hydroxy Phenyl linked Imidazolyl triazolo Hydroxamic Acid derivatives (FP1-FP12) and standard glibenclamide were administered per os (p.o.) in the streptozotocin-induced hyperglycemic rats by glucose oxidase-peroxidase method and statistically evaluated by one way analysis of variance.
Results: FP3 was potent as compare to standard glibenclamide (P < 0.05-0.001) and FP6, FP9, and FP4 were also effective as an antihyperglycemic agent. The activity profile of the molecule was as follows FP9< FP10< FP4< FP6<FP12< FP3. This study reflects that presence of para methoxy phenyl group linked with phenyl group in surface recognition portion and imidazolyl triazole group in linker portion associated with a sulfamethyl hydroxamic acid group in metal identifying the part in case of FP3 was resemble for antihyperglycemic activity.
Conclusion: It was concluded that compounds possessing electron releasing groups on the aromatic rings in the surface recognition part considerably enhanced the antihyperglycemic activity.
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