• Rekha Bora Laboratory of Ethnobotany and Medicinal Plants Conservation, Department of Ecology and Environmental Science, Assam University, Silchar-788011, India
  • Partha Pradip Adhikari Laboratory of Natural Product and Synthetic Organic Chemistry, Department of Chemistry, Assam University, Silchar-788011, India & Genoine Research Laboratory Pvt. Ltd., Subhash Nagar, Karimganj-788710, Assam, India
  • Ajit Kumar Das Laboratory of Ethnobotany and Medicinal Plants Conservation, Department of Ecology and Environmental Science, Assam University, Silchar-788011, India
  • Nanjian Raaman Center for Advanced Studies in Botany, University of Madras, Guindy Campus, Chennai-600025, India
  • Gauri Dutt Sharma Department of Life Science and Bioinformatics, Assam University, Silchar-788011, India & Bilaspur Vishwavidyalaya, Bilaspur-495001, Chhattisgarh, India



Acanthus, Acanthaceae, Ethnomedicinal uses, Phytochemistry, Pharmacology, Medicinal principles


Acanthus (family Acanthaceae) is a genus of the major group angiosperms (flowering plants) comprising more than 29 species widely distributed in the tropical and subtropical region. The aim of this review is to offer thorough scientific information on ethnomedicinal uses, phytochemical, and pharmacological activities of the plant species belonging to the genus Acanthus. Numerous traditional uses of the genus have been supported in this article from the results, and executed by the extracts and/or pure compounds obtained from pharmacological studies will provide a single platform to help future researches on the genus Acanthus. Furthermore, ethnomedicinal evaluation using fractions or isolation of medicinal principles was extensively explored by databases like Google, Google Scholar, and ScienceDirect at the same time. 


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Saranya A, Ramanathan T, Kesavanarayanan KS, Adam. Traditional medicinal uses, chemical constituents and biological activities of a mangrove plant, Acanthus ilicifolius Linn.: a brief review. Am Eur J Agric Environ Sci 2015;15:243-50.

Jiaqi H, Yunfei D, Wood JRI, Daniel TF. Acanthaceae. In: Al-Shehbaz. eds. Flora of China. Science Press, Beijing, and Missouri Botanical Garden Press: St. Louis, U. S. A; 2002;19:369-477.

Mabberley DJ. Mabberley’s Plant-Book: A portable dictionary of plants, their classification and uses. 3rd Edition. Cambridge University Press: Cambridge; 2008.

Duke N, Ball M, Ellison J. Factors influencing biodiversity and distributional gradients in mangroves. Glob Ecol Biogeogr Lett 1998;7:27-47.

Duke NC. Australia's mangroves: the authoritative guide to Australia's Mangrove Plants, University of Queensland; 2006.

Tomlinson P. The botany of mangroves. Cambridge tropical biology series. Cambridge, New York, USA: Cambridge University Press; 1986.

Yang Y, Yang S, Li J, Deng Y, Zhang Z, Xu S, et al. Transcriptome analysis of the holly mangrove acanthus ilicifolius and its terrestrial relative, acanthus leucostachyus, provides insights into adaptation to intertidal zones. BMC Genomics 2015;16:1-12.

Bora R, Das AK, Sharma GD. Ecology and taxonomic study Acanthus leucostachyus Wall. ex Nees: a promising ethnomedicinal plant from Assam. J Non-Timber Forest Prod 2013;20:95-8.

Tag H, Jeri L, Mingki T, Tsering J, Das AK. Higher plant diversity in pakke wildlife sanctuary and tiger reserve in east kameng district of arunachal pradesh: checklist–I. Pleione 2012;6:149-62.

IUCN. Guidelines for Using the IUCN Red List Categories and Criteria. Version 7 (August 2008). Prepared by the Standards and Petitions Working group of the IUCN-SSC Biodiversity Assessments Sub-committee, Huntingdon Road, Cambridge, UK; 2008. p. 1–70.

Hu J, Deng YF, Wood JRI, Daniel TF. Acanthaceae. Flora of China 2011;19:369-477.

Das AK, Dutta BK, Sharma GD, Hajra PK. Medicinal plants of southern Assam, deep publication, New Delhi-110063; 2010.

Baruah S, Sarma J, Roy H, Borthakur SK. Notes on two interesting angiosperms from Assam, India. Pleione 2013;7:401-5.

Barik SK, Haridasan K, Lakadong NJ. Medicinal plant resources of Meghalaya: Endemic threat status and consumption pattern. Envis Forestry Bull 2007;7:17-26.

Ragavan P, Saxena A, Mohan PM, Jayaraj RSC, Ravichandra K. Taxonomy and distribution of species of the genus Acanthus (Acanthaceae) in mangroves of the Andaman and Nicobar Islands, India. Boidversitas 2015;16:225-36.

Wang Y, Zhu H, Tam NFY. Polyphenols, tannins and antioxidant activities of eight true mangrove plant species in South China. Plant Soil 2014;374:549-63.

Amirul I, Saifuzzaman M, Ahmed F, Mustafizur R, Nazneen AS, Naher K. Antinociceptive activity of methanolic extract of Acanthus ilicifolius Linn. leaves. Turk J Pharm Sci 2012;9:51-60.

Nur KA, Mizanur R, Biswas S, Nasir A. Appraisals of bangladeshi medicinal plants used by folk medicine practitioners in the prevention and management of malignant neoplastic diseases. Int Scholarly Res Notices 2016;1-12. Doi:10.1155/2016/7832120.

Supriya B, Vijayakumar K, Subramanian N, Kumar D. Medicinal values of Putranjiva roxburghii-a review. Int J Curr Pharm Res 2017;9:1-4.

Bandaranayake WM. Bioactivities, bioactive compounds and chemical constituents of mangrove plants. Wetlands Ecol Manag 2002;10:421-52.

Chakraborty T, Bhuniya D, Chatterjee M, Rahaman M, Singha D, Chatterjee BN, et al. Acanthus ilicifolius plant extract prevents DNA alterations in a transplantable Ehrlich ascites carcinoma-bearing murine model. World J Gastroenterol 2007;13:6538-48.

Bandaranayake WM. Traditional and medicinal uses of mangroves. Mangroves Salt Marshes 1998;2:133-48.

Kumar KT, Gorain B, Roy DK, Samanta SK, Pal M, Biswas P, et al. Anti-inflammatory activity of Acanthus ilicifolius. J Ethnopharmacol 2008;120:7-12.

Sundaram R, Ganesan R, Murugesan G. In vitro antiplasmodial activity of spiro benzofuran compound from mangrove plant of Southern India. Asian Pac J Trop Med 2011;5:358-61.

Govindasamy C, Kannan R. Pharmacognosy of mangrove plants in the system of unani medicine. Asian Pac J Trop Dis 2012;2(Suppl 1):S38-S41.

Ganesh S, Vennila JJ. Screening for antimicrobial activity in Acanthus ilicifolius. Arch Appl Sci Res 2010;2:311–31.

Dey A, Raihan SM, Sariful Islam HM, Hamiduzzaman M, Monjur-Al-Hossain ASM. Phytochemical screening and the evaluation of the antioxidant, cytotoxic and antimicrobial properties of Acanthus ilicifolius (Family: Acanthaceae). Int Res J Pharm 2012;3:153-6.

Kirtikar KR, Basu BD. Indian medicinal plants. Vol. 8. 1st ed. Dehradun: International Book Distributors; 2001.

Jeeva S, Mishra BP, Venugopal N, Kharlukhi L, Laloo RC. Traditional knowledge and biodiversity conservation in the sacred groves of Meghalaya. Indian J Traditional Knowledge 2006;5:563-8.

Das AK, Dutta BK, Sharma GD. Medicinal plants used by different tribes of Cachar district, Assam. Indian J Traditional Knowledge 2008;7:446-54.

Singh OP, Tiwari BK, Lynser MB, Bharali S. Environmental accounting of natural resources of meghalaya: phase i–land and forest resources (Technical Report). the central statistical organization, the government of India, New Delhi; 2008.

Manikandaselvi S, Vadivel V, Brindha P. Review on ethnobotanical studies of nutraceutical plant: Capparis spinosa L. (Caper). Asian J Pharm Clin Res 2016;9:21-4.

Pfoze NL, Kehie M, Kayang H, Mao AA. Estimation of ethnobotanical plants of the Naga of North East India. J Med Plants Stud 2014;2:92-104.

Ahuja U, Ahuja SC. Alcoholic rice beverages. In: Encyclopaedia of the history of science, technology, and medicine in non-western cultures. Springer Netherlands, Dordrecht; 2014. p. 1-7.

Fongod AGN, Modjenpa NB, Veranso MC. Ethnobotany of acanthaceae in the mount cameroon region. J Med Plants Res 2013;7:2707-13.

Pradhan SD, Palei CN, Rath PB, Swain KK, Kar S. A new addition of mangrove species Acanthus ebracteatus Vahl. (Acanthaceae) to the mangrove flora of Bhitarkanika National Park, Odisha, India. Int J Innov Appl Res 2016;4:28-31.

Nguyen PD, Ho CL, Harikrishna JA, Wong MC, Rahim RA. Generation and analysis of expressed sequence tags from the mangrove plant, Acanthus ebracteatus Vahl. Tree Genet Genomes 2006;2:196-201.

Raut S, Khan S. Phytochemical fingerprinting of Acanthus ilicifolius L. Adv Plant Sci 2012;25:749-53.

Ralf W, Gerd L. Chemical composition of the mangrove holly Acanthus ilicifolius (Acanthaceae)-review and additional data. Frankfurt Main 2008;38:31-7.

Firdaus M, Prihanto AA, Nurdiani R, Widodo N. Antioxidant and cytotoxic activity of Acanthus ilicifolius flower. Asian Pacific J Trop Biomed 2013;3:17-21.

Govindasamy C, Arulpriya M. Antimicrobial activity of Acanthus ilicifolius: skin infection pathogens. Asian Pac J Trop Dis 2013,3:180-3.

Wu J, Zhang S, Huang J, Xiao Q, Li Q, Long L, et al. New aliphatic alcohol and (Z)-4-coumaric acid glycosides from Acanthus ilicifolius. Chem Pharm Bull 2003;51:1201-3.

Wu J, Zhang S, Xiao Q, Li Q, Huang J, Long L, et al. Phenylethanoid and aliphatic alcohol glycosides from Acanthus ilicifolius. Phytochemistry 2003;63:491-5.

Minocha PK, Tiwari KP. Chemical constituents of Acanthus ilicifolius Linn. Pol J Chem 1980;54:2089-90.

Minocha PK, Tiwari KP. A triterpenoid saponin from roots of Acanthus ilicifolius. Phytochemistry 1981;20:135-7.

Tiwari KP, Minocha PK, Masood M. Acanthicifoline-a new alkaloid from Acanthus ilicifolius. Pol J Chem 1980;54:857-8.

Murty MSR, Solimabi Kamat SY. Isolation of 2-benzoxazolinone from acanthus ilicifolius. Indian J Pharm Sci 1984;46:218-9.

Zhong LJ, Huang MY, Zhang JG, Li GW, Zhang YH. Study on the chemical constituents from Acanthus ilicifolius Linn. var. xiamenensis. Chin J Marine Drugs 2012;31:23-8.

Kokpol U, Chittawong V, Miles DH. Chemical constituents of the roots of Acanthus ilicifolius. J Nat Prod 1986;49:354.

D'Souza L, Wahidulla S, Mishra PD. Bisoxazolinone from the mangrove Acanthus ilicifolius. Indian J Chem Sect B 1997;36B:1079-81.

Kanchanapoom T, Kamel MS, Kasai R, Picheansoonthon C, Hiraga Y, Yamasaki K. Benzoxazinoid glucosides from Acanthus ilicifolius. Phytochemistry 2001;58:637-40.

Huo C, An D, Wang B, Zhao Y, Lin W. Structure elucidation and complete NMR spectral assignments of a new benzoxazolinone glucoside from Acanthus ilicifolius. Magn Reson Chem 2005;43:343-5.

Wu J, Zhang S, Xiao Q, Li Q, Huang J, Long L, et al. Megastigmane and flavone glycosides from Acanthus ilicifolius. Pharmazie 2003;58:363-4.

Clarke A, Gleeson P, Jermyn M, Knox R. Characterization and localization of lectins in lower and higher plants. Funct Plant Biol 1978;5:707-22.

Muhamad F, Prihanto AA, Nurdiani R. Antioxidant and cytotoxic activity of Acanthus ilicifolius flower. Asian Pac J Trop Biomed 2013;3:17-21.

Islam MA, Saifuzzaman M, Ahmed F, Rahman MM, Sultana NA, Naher K. Antinociceptive activity of Methanolic extract of Acanthus ilicifolius L. leaves. Turk J Pharm Sci 2012,9:51-60.

Van Kiem P, Quang TH, Huong TT, Nhung TH, Cuong NX, Van MC, et al. Chemical constituents of Acanthus ilicifolius L. and effect on osteoblastic MC3T3E1 cells. Arch Pharm Res 2008;31:823-9.

Babu BH, Shylesh BS, Padikkala J. Antioxidant and hepatoprotective effect of Acanthus ilicifolius. Fitoterapia 2001;72:272-7.

De Carvalho, PB Ferreira EI. Leishmaniasis phytotherapy. Nature’s leadership against an ancient disease. Fitoterapia 2001;72:599-618.

Babu BH, Shylesh BS, Padikkala J. Tumour reducing an anticarcinogenic activity of Acanthus ilicifolius. J Ethnopharmacol 2002;79:27-33.

Smitha RB, Madhusoodanan PV, Prakashkumar R. Anticancer activity of Acanthus ilicifolius Linn. from chettuva mangroves, Kerala, India. Int J Bioassays 2014;3:3452-5.

Zhang T, Tian Y, Jiang B, Miao M, Mu W. Purification, preliminary structural characterization and in vitro antioxidant activity of polysaccharides from Acanthus ilicifolius. LWT-Food Sci Technol 2014;56:9-14.

Asha KK, Mathew S, Lakshmanan PT. Flavonoids and phenolic compounds in two mangrove species and their antioxidant property. Indian J Mar Sci 2012;41:259-64.

Bose S, Bose A. Antimicrobial activity of Acanthus ilicifolius (L.). Indian J Pharm Sci 2008;70:821-3.

Rao SM, Teja G, Sirisha IR, Rao PY. Screening of antimicrobial activity of mangrove plant Acanthus ilicifolius on shrimp and fish pathogens. Asian J Plant Sci Res 2015;5:1-3.

Pradeep V, Khajure, Rathod JL. Antimicrobial activity of extracts of Acanthus ilicifolius extracted from the mangroves of from the mangroves of Karwar coast karnataka. Recent Res Sci Technol 2010;2:98-9.

Ravikumar S, Raja M, Gnanadesigan M. Antibacterial potential of benzoate and phenylethanoid derivatives isolated from Acanthus ilicifolius L. leaf extracts. Nat Prod Res 2012;26:2270-3.

Das A, Ahmed AB. Natural permeation enhancer for transdermal drug delivery system and permeation evaluation : a review. Asian J Pharm Clin Res 2017;10:7-11.



How to Cite

Bora, R., P. P. Adhikari, A. K. Das, N. Raaman, and G. D. Sharma. “ETHNOMEDICINAL, PHYTOCHEMICAL, AND PHARMACOLOGICAL ASPECTS OF GENUS ACANTHUS”. International Journal of Pharmacy and Pharmaceutical Sciences, vol. 9, no. 12, Dec. 2017, pp. 18-25, doi:10.22159/ijpps.2017v9i12.22386.



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