• Ahmed R. Gardouh Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Suez Canal University, Ismailia, Egypt,
  • Samar H. Faheim Department of Pharmaceutics, Faculty of Pharmacy, Horus University, New Damietta, Egypt,
  • Ahmed T. Noah Department of pharmaceutics, faculty of pharmacy, Delta University, Gamasa, Mansoura, Egypt.
  • Mamdouh M. Ghorab Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Suez Canal University



Nanostructured lipid carriers, Nanoemulsions, Surfactants, Liquid lipids, High Shear Homogenizer


Objective: The main purpose of this work was to elucidate the effect of certain formulation factors on the size of nanostructured lipid carriers (NLCs) and nanoemulsions (NEs) by using high shear homogenization method.

Methods: NLCs and NEs were prepared by high shear homogenization method using different liquid lipids types such as (Dermarol DCO® and Dermarol CCT®) at different concentrations. The effect of different concentration ratios of Tween 80 to Span 20 (2.5/1, 5/1, 10/1, 15/1) w/w % and different homogenization speeds (12 000, 18 000 rpm) on the resulted particle size were also studied.

Results: The results revealed that the optimum NLCs and NEs resulted when we use Dermarol CCT® with a concentration of 90 % as liquid lipid and decreasing surfactant ratio to (2.5/1) w/w % with increasing the homogenization speed to 18 000 rpm. 

Conclusion: NLCs and NEs were successfully prepared, and from this study, it can be concluded that NLCs have the optimum particle size than Nanoemulsions.


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Author Biography

Ahmed R. Gardouh, Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Suez Canal University, Ismailia, Egypt,

Pharmaceutics. highly ranked work done.


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How to Cite

Gardouh, A. R., S. H. Faheim, A. T. Noah, and M. M. Ghorab. “INFLUENCE OF FORMULATION FACTORS ON THE SIZE OF NANOSTRUCTURED LIPID CARRIERS AND NANOEMULSIONS PREPARED BY HIGH SHEAR HOMOGENIZATION”. International Journal of Pharmacy and Pharmaceutical Sciences, vol. 10, no. 4, Apr. 2018, pp. 61-75, doi:10.22159/ijpps.2018v10i4.23142.



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