INFLUENCE OF FORMULATION FACTORS ON THE SIZE OF NANOSTRUCTURED LIPID CARRIERS AND NANOEMULSIONS PREPARED BY HIGH SHEAR HOMOGENIZATION


Ahmed R. Gardouh, Samar H. Faheim, Ahmed T. Noah, Mamdouh M. Ghorab

Abstract


Objective: The main purpose of this work was to elucidate the effect of certain formulation factors on the size of nanostructured lipid carriers (NLCs) and nanoemulsions (NEs) by using high shear homogenization method.

Methods: NLCs and NEs were prepared by high shear homogenization method using different liquid lipids types such as (Dermarol DCO® and Dermarol CCT®) at different concentrations. The effect of different concentration ratios of Tween 80 to Span 20 (2.5/1, 5/1, 10/1, 15/1) w/w % and different homogenization speeds (12 000, 18 000 rpm) on the resulted particle size were also studied.

Results: The results revealed that the optimum NLCs and NEs resulted when we use Dermarol CCT® with a concentration of 90 % as liquid lipid and decreasing surfactant ratio to (2.5/1) w/w % with increasing the homogenization speed to 18 000 rpm. 

Conclusion: NLCs and NEs were successfully prepared, and from this study, it can be concluded that NLCs have the optimum particle size than Nanoemulsions.


Keywords


Nanostructured lipid carriers, Nanoemulsions, Surfactants, Liquid lipids, High Shear Homogenizer

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About this article

Title

INFLUENCE OF FORMULATION FACTORS ON THE SIZE OF NANOSTRUCTURED LIPID CARRIERS AND NANOEMULSIONS PREPARED BY HIGH SHEAR HOMOGENIZATION

Keywords

Nanostructured lipid carriers, Nanoemulsions, Surfactants, Liquid lipids, High Shear Homogenizer

DOI

10.22159/ijpps.2018v10i4.23142

Date

01-04-2018

Additional Links

Manuscript Submission

Journal

International Journal of Pharmacy and Pharmaceutical Sciences
Vol 10, Issue 4, 2018 Page: 61-75

Online ISSN

0975-1491

Authors & Affiliations

Ahmed R. Gardouh
Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Suez Canal University, Ismailia, Egypt,
Egypt

Samar H. Faheim
Department of Pharmaceutics, Faculty of Pharmacy, Horus University, New Damietta, Egypt,
Egypt

Ahmed T. Noah
Department of pharmaceutics, faculty of pharmacy, Delta University, Gamasa, Mansoura, Egypt.
Egypt

Mamdouh M. Ghorab
Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Suez Canal University
Egypt


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