EFFECT OF ADDITIVES ON IN-VITRO RELEASE OF ORODISPERSIBLE DOSAGE FORM

  • Mamdouh M. Ghorab Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Suez Canal University, Ismailia 41522, Egypt.
  • Mohamed M. Elsayed Department of Pharmaceutics, Faculty of Pharmacy and Pharmaceutical Industries, Sinai University, El-Arish, North Sinai, Egypt.
  • Ali M. Nasr Department of Pharmaceutics, Faculty of Pharmacy and Pharmaceutical Industries, Sinai University, El-Arish, North Sinai, Egypt.
  • Shadeed Gad Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Suez Canal University, Ismailia 41522, Egypt.

Abstract

Objective: The aim of this investigation was to prepare orodispersible tablets of meloxicam using various concentrations of superdisintegrants like Ac-DI-Sol, crospovidone, sodium starch glycolate by the direct compression method.

Methods: Nine formulae of Meloxicam orodispersible tablets were prepared. These tablets were evaluated for their drug content, weight variation, friability, hardness, wetting time, In-vitro disintegration time and drug release.

Results: All the formulation exhibited hardness between 4.21–4.55 kg/cm2. The tablets were disintegrating within 8.3 to 21.9 sec. Dissolution studies revealed that formula containing 7.5 % sodium starch glycolate showed 100% of drug release, at the end of six minutes. Among the formulated tablets, formula F9 containing 7.5 % sodium starch glycolate showed superior organoleptic properties along with excellent In-vitro disintegration time and drug release as compared to other formulae. The concentration of superdisintegrants had an effect on disintegration time and In-vitro drug dissolution whereas hardness and friability of resulting tablets were found to be independent of disintegrant concentration. It was concluded that the superdisintegrants addition technique is a useful method for preparing orodispersible tablets by the direct compression method.

 

Keywords: Meloxicam, Orodispersible tablets, Ac-Di-Sol, Crospovidone, Sodium starch glycolate, Superdisintegrant, Direct Compression, In-vitro

Downloads

Download data is not yet available.

References

1. Chein yw. Oral drug delivery and delivery system, 2nd, New York: Marcel Dekker; 1992:587-682.
2. Indurwade NH, Rajyaguru TH, Nakhat PD. Novel approach–fast dissolving tablets. Indian Drugs 2002;39(8):405-9.
3. Radke RS, Jadhav JK, Chajeed MR. Formulation and evaluation of orodispersible tablets of baclofen. Int J Chem Tech Res 2009;1(3):517-21.
4. Deshpande Kiran Bhaskar, More MR, GN Sockan, Kunchu K, Tamiz Mani. Formulation and evaluation of orodispersible tablets of propranolol hydrochloride. Int J Pharm Res Dev 2011;2(12):214-9.
5. Shastry CS, Srinath MS. pharmaceutical approaches of taste masking oral dosage forms. Ind Drug 2004;41(5):253-7.
6. Bhushan SY, Sambhaji SP, Anant RP, Mahadik KR. New drug delivery system for elderly. Indian Drugs 2003;37(7):312-8.
7. Seager H. Drug delivery product and zydis fast dissolving dosage form. J Pharm Pharmcol 1998;50:375-82.
8. Mishra B, Panigrahi D. Mouth dissolving tablets: an overview of preparation techniques, evaluation and patented technologies. J Pham Res 2005;4(3):33-6.
9. Dandagi PM, Sreenivas SA, Mastiholimath VS. Orodispersible tablets: new-fangled drug delivery system-a review. Ind J Pharm Edu Res 2005;39(4):177-81.
10. Allen LV, Wang B. Method of making a rapidly dissolving tablet US Patent; 1997.
11. Kaushik D, Dureja H, Saini TR. Review article: mouth dissolving tablets. Ind Drugs 2004;41(4):187-93.
12. Corveleyn S, Remon JP. Formulation and production of rapidly disintegrating tablets by lyophilization using hydrochlorothiazide as a model drug. Int J Pharm 1997;152:215-25.
13. Remon JP, Corveleyn S. Freeze-dried rapidly disintegrating tablets US patent 6 010 719
14. Heinemann H, Rothe W. Preparation of porous tablets. 1975 US patent 3 885 026.
15. Knistch A, Hagen E, Munz H D. Production of porous tablets. 1979 US patent 4 134 843.
16. Shariff A, Monna PK, Paranjothy KLK, Manjula M. Entrapment of andrographolide in cross linked alginate pellets. Pak J Pharm Sci 2007;20:1-9.
17. Tayade PT, Kale RD. Encapsulation of water-insoluble drugs by a cross-linking technique: effect of process and formulation variables on encapsulation efficiency, particle size, and In vitro dissolution rate. Pharm Sci 2004;6:12-9.
18. Staniforth J. in "Powder Flow In Pharmaceutics", Aulton M. E., (ed.). 2nd ED., Churchill Livingstone, London; 2002. p. 207.
19. Kumar V, Medina MLR, Yang D. Preparation, Characterization, and tableting properties of a new cellulose-based pharmaceutical aid. Int J Pharm 2002;235(1-2):129-40.
20. Chaudhari PD, Chaudhari SP, Lanke SD. Formulation and In vitro evaluation of taste masked orodispersible dosage form of levocetirizine dihydrochloride. Indian J Pharm Educ Res 2007;41(4):319-28.
21. Kuchekar BS, Badhan AC, Mahajan HS. Mouth dissolving tablets of salbutamol sulphate: a novel drug delivery system. Indian Drugs 2004;41(10):592-8.
22. Marshall K, Lachman N, Liberman HA. The theory and practice of industrial pharmacy, 3rd Ed, Varghese Publishing House, Mumbai; 1987. p. 66-9.
23. Khan S, Kataria P, Nakhat P, Yeole P. Taste masking of ondansetron hydrochloride by polymer carrier system and formulation of rapid-disintegrating tablets. AAPS Pharm Sci Tech 2007;8(2):1-7.
24. M Gohel, M Patel, A Amin, R Agrawal, R Dave, N Bariya. Formulation, Design and optimization of mouth dissolve tablets of nimesulide using vacuum drying technique. AAPS Pharm Sci Tech 2004;5(3):10–5.
25. Singh J, Philip AK, Pathak K. Optimization studies on design and evaluation of orodispersible pediatric formulation of indomethacin. AAPS Pharm Sci Tech 2008;9(1):60-6.
26. British pharmacopoeia, BP. The British Pharmacopoeia, The Pharmaceutical Press, London, UK; 2009.
27. Jashanjit Singh, Rajmeet Singh. Optimization and formulation of orodispersible tablets of meloxicam. Trop J Pharm Res 2009;8(2):153-9.
28. Shah UA, Augsburger LG. Evaluation of the functional equivance of crospovidone NF from different sources: standard performance test. Pharm Dev Technol 2001;6:419-30.
29. Weller P. In; Handbook of Pharmaceutical Excipients; 4th Edn. Pharmaceutical Press. London; 2003.
30. The United States Pharmacopeia: USP 30/NF 25, the USP Convention, Rockville; 2007. p. 2960.
31. Bi X, Sunada H, Yonezawa Y, Danjo K. Evaluation of rapidly disintegrating tablets prepared by a direct compression method. Drug Dev Ind Pharm 1999;25(5):571-81.
32. Bhowmik D, Chiranjib B, Krishnakanth Pankaj R, Chandira M. Fast dissolving tablet. J Chem Pharm Res 2009;1(1):163-77.
33. Sahoo SK, Mallick AA, Barik BB, Senapati PC. Preparation and In vitro evaluation of ethylcellulose microspheres containing stavudine by the double emulsion method. Pharm 2007;62:117-21.
Statistics
285 Views | 854 Downloads
How to Cite
Ghorab, M. M., M. M. Elsayed, A. M. Nasr, and S. Gad. “EFFECT OF ADDITIVES ON IN-VITRO RELEASE OF ORODISPERSIBLE DOSAGE FORM”. International Journal of Pharmacy and Pharmaceutical Sciences, Vol. 7, no. 2, Dec. 2014, pp. 283-9, https://innovareacademics.in/journals/index.php/ijpps/article/view/4078.
Section
Original Article(s)