PREPARATION OF BUDESONIDE-PECTIN BEADS USING THE PERISTALTIC PUMP


Samir A. Atara, Moinuddin M. Soniwala

Abstract


Objective: To formulate and evaluate budesonide-pectin beads using novel assembly with a peristaltic pump.

Methods: The prepared budesonide-pectin dispersion was added to calcium chloride solution with the help of assembly. Provided at least 2 h for hardening and dried at 60 °C for 3 h. Assembly was assembled with the use of a peristaltic pump, polymeric solution reservoir, hose, needle, magnetic stirrer, gelling bath. One side of hose was dipped in pectin solution container and another side was passed through the peristaltic pump and connected to the needle. Peristaltic pump produced pumping of pectin solution through the hose. Needles with variable diameters are available. The gelling bath was kept on magnetic stirrer to keep prepared beads in motion, which helped to provide new surface and sufficient reaction time and helped to avoid agglomeration. There were 10 different batches with different process parameters prepared. Production yield, the diameter of beads, swelling index, and in vitro budesonide dissolution in phosphate buffer pH 7.4 after 5 h was determined.

Results: There was a significant difference between selection of process parameter among the batches (p = 0.049, q = 6.11). As nozzle diameter was increased, percentage yield was decreased (p = 0.0038, q>5.98). However, if hardening time was decreased percentage release was increased (p = 0.0361, q>5.98).

Conclusion: The novel assembly for bead generation had developed a uniform, spherical shaped, and smooth surfaced beads.


Keywords


Beads, Micrometric properties, Peristaltic pump, Process parameters

| HTML | PDF |

References


Sandborn WJ, Travis S, Moro L, Jones R, Gautille T, Bagin R, et al., Once-daily budesonide MMX® extended-release tablets induce remission in patients with mild to moderate ulcerative colitis: results from the CORE I study. Gastroenterology 2012;143:1218–26.

Garud S, Peppercorn MA. Ulcerative colitis: current treatment strategies and future prospects. Ther Adv Gastroenterol 2009;2:99–108.

Tran VT, Benoit JP, Venier-Julienne MC. Why and how to prepare biodegradable, monodispersed, polymeric microparticles in the field of pharmacy? Int J Pharm 2011;407:1–11.

Klokk TI, Melvik JE. Controlling the size of alginate gel beads by use of a high electrostatic potential. J Microencapsul 2002;19:415–24.

Hmpmel M, Sun AM, Goosen MF. Droplet generation. US Patent: US4956128A. 1990. p. 1–9.

Wang F, Li Z, Lannutti JL, Wagner WR, Guan J. Synthesis, characterization and surface modification of low moduli poly (ether carbonate urethane) urease for soft tissue engineering. Acta Biomater 2009;5:2901–12.

Bourgeois S, Gernet M, Pradeau D, Andremont A, Fattal E. Evaluation of critical formulation parameters influencing the bioactivity of beta-lactamases entrapped in pectin beads. Int J Pharm 2006;324:2–9.

Xing P, Shi Y, Dong C, Liu H, Cheng Y, Sun J, et al. Colon-targeted delivery of IgY against Clostridium difficile toxin A and B by encapsulation in chitosan-Ca pectinate microbeads. AAPS PharmSciTech 2017;18:1095–103.

Mennini N, Furlanetto S, Maestrelli F, Pinzauti S, Mura P. Response surface methodology in the optimization of chitosan-Ca pectinate bead formulations. Eur J Pharm Sci 2008;35:18–25.

Korat PS, Kapupara PP. Local infiltration of the surgical wound with levobupivacaine, ibuprofen, and epinephrine in postoperative pain: an experimental study. Biomed Pharmacother 2017;96:104–11.

McClements DJ. Designing biopolymer microgels to encapsulate, protect and deliver bioactive components: physicochemical aspects. Adv Colloid Interface Sci 2017;240:31–59.

Vishwakarma N, Ganeshpurkar A, Pandey V, Dubey N, Bansal D. Mesalazine-probiotics beads for acetic acid experimental colitis: formulation and characterization of a promising new therapeutic strategy for ulcerative colitis. Drug Delivery 2015;22:94–9.




About this article

Title

PREPARATION OF BUDESONIDE-PECTIN BEADS USING THE PERISTALTIC PUMP

Keywords

Beads, Micrometric properties, Peristaltic pump, Process parameters

DOI

10.22159/ijpps.2018v10i1.23171

Date

01-01-2018

Additional Links

Manuscript Submission

Journal

International Journal of Pharmacy and Pharmaceutical Sciences
Vol 10, Issue 1, 2018 Page: 169-171

Online ISSN

0975-1491

Authors & Affiliations

Samir A. Atara
School of Pharmacy, RK University, Rajkot, Gujarat, India
India

Moinuddin M. Soniwala
B. K. Mody Govt. College of Pharmacy, Rajkot, Gujarat, India
India


Article Tools



Refbacks