DRUG UTILIZATION BASED ADRs DETECTION OF ANTIBIOTICS PRESCRIBED FOR LRTI IN TERTIARY CARE TEACHING HOSPITAL, NEW DELHI


Md Shamim, Mohammad Daud Ali, Md Sarfaraz Alam, Md Sajid Ali, Sarfaraz Ahmad, Md Salahuddin Ansari

Abstract


Objective: Aim of to present study was to assess drug utilization pattern of antibiotics use in Lower respiratory tract infection and their adverse drug reaction assessment.

Methods: The present study was an observational and prospective study. 110 patients fulfill the inclusion criteria were included in study. Physician prescription records, patient’s medication profile types of antibiotics prescribed were recorded and analyzed.

Results: Out of 110 LRTI patients, 74 (67.27%) patients were male and 36(32.72%) patients were female. 72 patients were suffered from bronchitis while 38 patients were suffering from pneumonia. 30 patients were in the age range of 56-65 y, followed by 21 patients who were in the age range of 66-75 y. It has been observed that among all the prescribed antibiotic agent's frequency of β-lactam 199(45.53%), quinolones115 (26.27%), macrolides 53(12.12%) chloramphenicol44 (10.06%) sulphonamide 17 (3.89%) and aminoglycosides 9(2.05%) were prescribed to all the patients. Average 3.97 antibiotic agents were prescribed to all the patients. Majority of drugs were given by oral route (68.19%) and Prescriptions are mainly ordered in brand names. The most frequent co-morbid condition was found to be diabetes mellitus (25.45%) followed by hypertension (16.36%) and coronary artery disease (11.81%).45.45%. Only 23 ADRs were detected in 110 patients. The most common culprit was an amoxicillin with clavulanic acid.

Conclusion: The present study provides an overall pattern of antibiotic usage in different patients. The area of concern in the present study is polypharmacy and use of antibiotics in LRTI without following any guideline. ADRs monitoring is also required to prevent noxious effects of drugs by the use of antibiotics.


Keywords


Drug utilization Review, Adverse drug reaction (ADR), Lower respiratory tract infection (LRTI), Inpatient, Outpatient

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About this article

Title

DRUG UTILIZATION BASED ADRs DETECTION OF ANTIBIOTICS PRESCRIBED FOR LRTI IN TERTIARY CARE TEACHING HOSPITAL, NEW DELHI

Keywords

Drug utilization Review, Adverse drug reaction (ADR), Lower respiratory tract infection (LRTI), Inpatient, Outpatient

DOI

10.22159/ijpps.2018v10i4.23368

Date

01-04-2018

Additional Links

Manuscript Submission

Journal

International Journal of Pharmacy and Pharmaceutical Sciences
Vol 10, Issue 4, 2018 Page: 7-14

Online ISSN

0975-1491

Authors & Affiliations

Md Shamim
College of Pharmacy, Teerthanker Mahaveer University, Muradabad U.P India
India

Mohammad Daud Ali
Department of pharmacy, Mohammed almana college of health sciences, Abdulrazaq Bin Hammam Street, As Safa, Dammam 34222 KSA
Saudi Arabia

Md Sarfaraz Alam
Department of Pharmaceutics, College of Pharmacy, Jazan University, Jazan, KSA
Saudi Arabia

Md Sajid Ali
Department of Pharmaceutics, College of Pharmacy, Jazan University, Jazan, KSA

Sarfaraz Ahmad
Department of Pharmaceutics, College of Pharmacy, Jazan University, Jazan, KSA
Saudi Arabia

Md Salahuddin Ansari
Department of Pharmacy Practice, College of Pharmacy Aldawadmi, Shaqra University, Saudi Arabia
Saudi Arabia


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