A COMPARATIVE EVALUATION OF THE EFFICACY OF TRIPLE DRUG THERAPY WITH DUAL DRUG THERAPY IN COPD PATIENTS


Pathan Amanulla Khan, A. Sujala, B.b. Sarah Nousheen, Ayesha Farhath Fatima, Hibba Tul Ala, A.b.t. Pallavi Reddy

Abstract


Objective: The present study was conducted with the objective of analyzing the efficacy of triple-drug combination therapy (formoterol, ciclesonide, tiotropium) by comparing it with double drug combination therapy (formoterol, budesonide).

Methods: A prospective observational study was conducted. Sixty patients were enrolled, and divided into two groups of thirty each; one group was treated with the double-drug and the other with a triple drug combination. FEV1 and FVC pre-and post-treatment in either group were assessed spirometrically. Score ranges of 0-10, 11-20 and 21-30 were allotted to mild, moderate and severe categories and results were analyzed statistically.

Results: Of the 60 patients recruited, 61-70 y olds constituted the majority (35%) of the population. Males (63.3%) were more in number compared to females (36.6%). Twenty-three of thirty-eight men smoked (60.5%); there were no female smokers. Common symptoms included cough (93.3%), dyspnoea (85%), fever (45%) and haemoptysis (15%). Hypertension accounted for 70% of patient comorbidities, followed by diabetes (60%) and cardiovascular diseases (40%). Three months after treatment with triple therapy, a significant increase in the differences of means of both FEV1 (14.27) and FVC (14.90) values was observed. Further analysis based on score ranges demonstrated that triple therapy administration markedly reduced the number of patients suffering from severe COPD.

Conclusion: Our comparative analysis indicated that triple therapy was more effective in improving lung function, enhancing patients’ quality of life (evidenced from score ranges) thereby reducing mortality. While much is known about the greater effectiveness of triple over dual therapy, researchers to formulate the most effective triple therapy are in progress.


Keywords


Chronic obstructive pulmonary disease (COPD), Inhaled corticosteroids, Long-acting β2 agonist, Long-acting muscuranic antagonist, Spirometry

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About this article

Title

A COMPARATIVE EVALUATION OF THE EFFICACY OF TRIPLE DRUG THERAPY WITH DUAL DRUG THERAPY IN COPD PATIENTS

Keywords

Chronic obstructive pulmonary disease (COPD), Inhaled corticosteroids, Long-acting β2 agonist, Long-acting muscuranic antagonist, Spirometry

DOI

10.22159/ijpps.2018v10i4.24529

Date

01-04-2018

Additional Links

Manuscript Submission

Journal

International Journal of Pharmacy and Pharmaceutical Sciences
Vol 10, Issue 4, 2018 Page: 105-109

Online ISSN

0975-1491

Authors & Affiliations

Pathan Amanulla Khan
Department of Clinical Pharmacy and Therapeutics, Anwarul Uloom College of Pharmacy, Hyderabad, Telangana, India,
India

A. Sujala
Department of Pharmacy Practice, Bharat Institute of Technology-Pharmacy, Hyderabad, Telangana, India,
India

B.b. Sarah Nousheen
Pharm D 4th year, Anwarul Uloom College of Pharmacy, Hyderabad, Telangana, India,

Ayesha Farhath Fatima
Department of Pharmaceutics, Anwarul Uloom College of Pharmacy, Hyderabad, Telangana, India

Hibba Tul Ala
Department of Pharmacy Practice, Bharat Institute of Technology-Pharmacy, Hyderabad, Telangana, India,

A.b.t. Pallavi Reddy
Department of Pharmacy Practice, Bharat Institute of Technology-Pharmacy, Hyderabad, Telangana, India,


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