GENOTYPE AND ABO BLOOD GROUP ASSOCIATION WITH PREVALENCE OF MALARIA AMONG PATIENTS IN UNIVERSITY OF NIGERIA MEDICAL CENTER: A CROSS-SECTIONAL EVALUATION
Objective: The aim of this study was to evaluate the prevalence of malaria and its relationship with the ABO blood group and genotype at the University of Nigeria Medical Centre.
Methods: The study had a prospective cross-sectional design in which malaria status and blood groups and genotype were determined. All collected data were analysed using Statistical product and services Solution (V.21). Frequencies and percentages were used to describe the data while Chi-square and Pearson correlation were used to determine associations between malaria prevalence and patients’ demographic and clinical characteristics. Statistical significance was considered for p<0.05.
Results: Three hundred and twenty-three (323) patients were tested for malaria, 245(75.9%) of whom tested positive. The prevalence was highest for patient’s aged 19-25 y (28.5%). The difference was statistically significant for age: χ2 (5) = 33.60, p = 0.0005. There were more blood group O (57.6%) among the patients, while AA genotype was the majority (72.4%). Those with blood group O had the highest prevalence of malaria (33.7%) and it was statistically significant (χ2 (3) = 72.10, p = 0.0005)). Correlation showed that the association between blood group and malaria prevalence was moderate (R = 0.457). The AA genotype had more incidence of malaria (54.5%), but the difference was not statistically significant.
Conclusion: The prevalence of malaria was high among the patients surveyed. Its association with the patients’ ABO blood group was established to be statistically significant, with blood group O having the highest incidence. Although AA genotype was observed to have the highest cases of malaria, the relationship was found not to be significant.
2. World Health Organization. Malaria. World Health Organization; 2017. Available from: http://www.who.int/ mediacentre/factsheets/fs094/en/. [Last accessed 11 January 2018].
3. Sonar YA, Bele MH, Sonar NH, Bagul VS, Shimpi PS. Taste abatement and characterization of dispersible tablets of artemether prepared by hot melt extrusion. Int J Appl Pharm 2017;9:28-33.
4. Arama C, Troye-Blomberg M. The path of malaria vaccine development: challenges and perspectives. J Intern Med 2014;275:456–66.
5. Hill AVS. Vaccines against malaria. Philos Trans R Soc Lond B Biol Sci 2011;366:2806-14.
6. Lorenz V, Karanis G, Karanis P. Malaria vaccine development and how external forces shape it: an overview. Int J Environ Res Public Health 2014;11:6791-807.
7. Ojiezeh TI, Ibeh NI, Opedun DO, Udoh SJ. Malaria endemicity among pregnant women in urban and semi-urban areas in Southwest, Nigeria. Am J Sci Res 2010;5:207–11.
8. William CM, Richard SD, Robert BG. Parasitology and vector biology. Second. Harcourt: Academic Press California; 2000.
9. Ito EE, Egwunyenga AO, Ake JEG. Prevalence of malaria and human blood factors among patients in Ethiope East, Delta State, Nigeria. Int J Med Biomed Res 2014;3:191-201.
10. Fortin A, Stevenson MM, Gros P. Susceptibility to malaria as a complex trait?: big pressure from a tiny creature. Hum Mol Genet 2002;11:2469–78.
11. Driss A, Hibbert JM, Wilson NO, Iqbal SA, Adamkiewicz TV, Stiles JK. Genetic polymorphisms linked to susceptibility to malaria. Malar J 2011;10:271.
12. Mendonc VRR De, Goncalves MS, Barral-netto M. The host genetic diversity in malaria infection. J Trop Med 2012;1-17. http://dx.doi.org/10.1155/2012/940616
13. World Health Organization. Malaria Parasite Counting. Geneva; 2016. Available from: http://www.wpro.who.int/mvp/ lab_quality/2096_oms_gmp_sop_09_rev1.pdf. [Last accessed 11 Jan 2018]
14. Bejon P, Andrews L, Hunt Cooke A, Sanderson F, Gilbert SC, Hill AVS. Thick blood film examination for Plasmodium falciparum malaria has reduced sensitivity and underestimates parasite density. Malar J 2006;5:104.
15. Olaitan L. Perception of university students on unwanted pregnancy in southwest Nigeria. Am J Soc Manag Sci 2010;1:196–200.
16. Ndifon W, Ogaji D, Etuk S. Sexuality, contraception and unintended pregnancy among female student nurses in Calabar, Nigeria. Benin J Postgrad Med 2006;8:12–21.
17. Makanjuola AB, Daramola TO, Obembe AO. Psychoactive substance use among medical students in a Nigerian university. World Psychiatry 2007;6:112–4.
18. Oyetola EO, Oyewole T, Adedigba M, Aregbesola ST, Umezudike K, Adewale A. Knowledge and awareness of medical doctors, medical students and nurses about dentistry in Nigeria. Pan Afr Med J 2016;23:1–12.
19. Chima Anyanwu F, Ter Goon D, Tugli A. Perception on the severity of unwanted pregnancy among university students. Pakistan J Med Sci 2013;29:923-8.
20. Ahmed ZD, Sule IB, Abolaji ML, Mohammed Y, Nguku P. Knowledge and utilization of contraceptive devices among unmarried undergraduate students of a tertiary institution in Kano State, Nigeria 2016. Pan Afr Med J 2017;26:103.
21. Adekanle DA, Adeniji AO. Emergency contraception: knowledge and practices of tertiary students in osun state, South Western Nigeria. Gynecol Obstet 2014;4:1.
22. Omobuwa O, Alebiosu O. Awareness of diabetes amongst undergraduates in a Nigerian University, South West Nigeria. Sahel Med J 2014;17:29.
23. Ojule J, Oriji V, George will K. Awareness and practice of emergency contraception among students of university of port harcourt, South-South Nigeria. Niger Heal J 2008;8:6–9.
24. Sarangi R, Pattnaik L, Satpathy SK, Sahu MC. Mortality pattern of under-five children–a hospital-based cross-sectional study in a tertiary care hospital of india. Asian J Pharm Clin Res 2017;10:82.
25. Gupta P, Gupta P, Rao S, Singh N, Kalita D. Comparison between microscopy and rapid diagnostic tests in diagnosis of malaria at a tertiary care medical institution in Uttarakhand (a 3-year study). Asian J Pharm Clin Res 2018;11:94.
26. Zerihun T, Degarege A, Erko B. Association of ABO blood group and Plasmodium falciparum malaria in. Asian Pac J Trop Biomed 2011;1:289–94.
27. Tekeste Z, Petros B. The ABO blood group and Plasmodium falciparum malaria in Awash, Metehara and Ziway areas, Ethiopia. Malar J 2010;9:280.
28. Opara KN, Atting IA, Ukpong IG, Nwabueze AA, Inokon II. Susceptibility of genetic indices to falciparum malaria in infants and young children in Southern Nigeria. Pakistan J Biol Sci 2006;9:452–6.
29. Otajevwo FD. Prevalence of Malaria parasitaemia and its association with ABO blood grouping among students of igbinedion University Okada, Nigeria. Br J Med Med Res 2013;3:1164–77.
30. Muntaka S, Opoku Okrah C. The prevalence of malaria parasitaemia and predisposition of ABO blood groups to plasmodium falciparum malaria among blood donors at a ghanaian hospital. Au J T 2013;16:255–60.
31. Bamou R, Sevidzem SL. ABO/Rhesus blood group systems and malaria prevalence among students of the University of dschang, cameroon. Malaria World J 2016;7:5–8.
32. Rowe JA, Handel IG, Thera MA, Deans A, Lyke KE, Kone A, et al. Blood group O protects against severe Plasmodium falciparum malaria through the mechanism. PNAS 2007;104:44.
33. Migot Nabias F, Mombo LE, Luty AJF, Dubois B, Nabias R, Bisseye C, et al. Human genetic factors related to susceptibility to mild malaria in Gabon. Genes Immun 2000;1:435–41.
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