ADHERENCE TO ESSENTIAL HYPERTENSION TREATMENT GUIDELINES IN A TERTIARY HOSPITAL IN NIGERIA

  • ISAAC CHIJIOKE IBEZIM Department of Clinical Pharmacy and Pharmacy Management, University of Nigeria, Nsukka, Enugu State, Nigeria
  • IAN NAYLOR School of Pharmacy, University of Bradford, United Kingdom
  • ABDULMUMINU ISAH Department of Clinical Pharmacy and Pharmacy Management, University of Nigeria, Nsukka, Enugu State, Nigeria
  • NNEKA UCHENNA IGBOELI Department of Clinical Pharmacy and Pharmacy Management, University of Nigeria, Nsukka, Enugu State, Nigeria

Abstract

Objective: This study determined the level of prescribers’ adherence to the World Health Organization/International Society of Hypertension (WHO/ISH) guidelines for the management of hypertension at the Lagos University Teaching Hospital (LUTH), Nigeria.


Methods: This study employed a retrospective cross-sectional design. Two groups were used: Group A (300 patients) were treated before the guidelines review in 2003, while Group B (200 patients) were treated after. The two study groups were compared, and systolic blood pressure of 130 mm Hg or above was taken as the index of hypertension.


Results: There were 198 (66%) male patients in Group A, while Group B had 136 (68%) males. The highest age for Group A was 50–59 y for 89 (30%) patients, unlike group B that had 58 (29%) patients in aged 40–49 y as the highest. The highest blood pressure range for patients in Group A was 150–159 mm Hg for 64 (21%) patients, unlike Group B that had 43 (22%) patients as the highest in the same range. Furosemide was present in 282 (24%) prescriptions for group A patients. However, atenolol was present in 61 (20%) prescriptions for the same group. In group B, Furosemide was prescribed in 197 (97%) encounters, while Nifedipine was found in 81(40%) prescriptions.


Conclusion: Prescribers at LUTH complied substantially with WHO/ISH guidelines in the management of hypertension. Diuretics and beta-blockers were used before the guideline review. After the review, diuretics and calcium channel blockers were the most frequently prescribed antihypertensives.

Keywords: Hypertension, Adherence, Treatment Guidelines, WHO/ISH

Downloads

Download data is not yet available.

Author Biography

ABDULMUMINU ISAH, Department of Clinical Pharmacy and Pharmacy Management, University of Nigeria, Nsukka, Enugu State, Nigeria

Department of Clinical Pharmacy and Pharmacy Management,

University of Nigeria,

Nsukka 410001,

Enugu State,

Nigeria.

Lecturer II

References

1. World Health Organization. Hypertension Available from http://www.who.int/news-room/fact-sheets/detail/hypertension. [Last accessed on 25 Oct 2019]
2. Kearney PM, Whelton M, Reynolds K, Whelton PK, He J. Worldwide prevalence of hypertension: a systematic review. J Hypertens 2004;22:11-9.
3. Michael R. The American society of hypertension and the international society of hypertension guidelines for hypertension management: an in-depth guide. Specialty Pharm Times 2014;53:31.
4. Odili VU, Oghagbon EK, Ugwa NA, Ochei UM, Agghomo OE. Adherence to international guidelines int eh management of hypertension in a tertiary Hospital in Nigeria. Trop J Pharm Res 2008;7:945-52.
5. James PA, Oparil S, Cartel BL, Cusham WC, Dennison Himmelfarb C, Handler J, et al. Evidence-based guideline for the management of high blood pressure in adults report from the panel members appointed to the Eight Joint National Committee (JNC 8). JAMA 2014;311:507-20.
6. Ale OK, Braimoh RW. Awareness of hypertension guidelines and the diagnosis and evaluation of hypertension by primary care physicians in Nigeria. Cardiovasc J Afr 2017;28:72-6.
7. Basopo V, Mujasi P. To what extent do prescribing practices for hypertension in the private sector in Zimbabwe follow the national treatment guidelines? An analysis in insurance medical claims. J Pharm Policy Prac 2017;10:37.
8. Solanki ND, Patel P. Drug utilization pattern and pharmacoeconomic analysis of antihypertensive drugs prescribed in secondary care hospital in Gujarat India. Asian J Pharm Clin Res 2017;10:120-4.
9. Vyas ND, Gor AP, Suthar JV. Evaluation of prescribing pattern of fixed dose combinations of antihypertensives and antidiabetic agents. Asian J Pharm Clin Res 2017;10:164-6.
10. Varakantham V, Kurakula SAK, Bharatraj DK. Antihypertensive prescription pattern and compliance to JNC 7 AND JNC 8 AT tertiary care Government Hospital, Hyderabdd, India: a cross-sectional retrospective study. Hosp Pharm 2018;53:107-12.
11. Nasytion A. Drug therapy problems in management of hypertensive outpatients admitted to four Indonesian primary health centers. Asian J Pharm Clin Res 2016;9:87-90.
12. Sari SP, Darajat AF, Nursanti B. Drug interactions among patients with hypertension taking angiotensin-converting enzyme inhibitors in an Indonesian hospital. Int J Appl Pharm 2018;10:138-41.
13. Venkataraman R, Rashid M, Shashikantha B, Soumya A, Vijayan G, Manuel GG, et al. Prescribing pattern of antihypertensive medication and adherence to Joint National Commission–8 guideline in a rural tertiary care Indian Teaching Hospital. J Basic Clin Physiol Pharmacol 2019. Doi:10.1515/jbcpp-2019-0133
14. Sessoms J, Reid K, Williams I, Hinton I. Provider adherence to the national guideline for managing hypertension in African Americans. Int J Hypertens 2015. https://doi.org/ 10.1155/2015/498074
15. Heneghan C, Perera R, Mant D, Glasziou P. Hypertension guideline recommendations in general practice: awareness, agreement, adoption, and adherence. Br J Gen Pract 2008;57:948-52.
16. Milchak JL, Carter BL, James PA, Ardey G. Measuring adherence to practice guidelines for the management of hypertension. Evaluation Literature Hypertension 2004;44:602-8.
17. Ahmad N, Hassan Y, Tangiisuran B, Meng OL, Abd Aziz N, Ahmad FU, et al. Guideline adherence and hypertension control at a tertiary hospital in Malayia. J Eval Clin Pract 2013;19:798-804.
18. Rajagopal SS, Kandasamy K, Natarajan A. Impact of pharmacist intervention in screening and education on blood pressure in a rural area in southern India. Asian J Pharm Clin Res 2016;9(Suppl 3):339-43.
Statistics
24 Views | 7 Downloads
Citatons
How to Cite
IBEZIM, I. C., I. NAYLOR, A. ISAH, and N. U. IGBOELI. “ADHERENCE TO ESSENTIAL HYPERTENSION TREATMENT GUIDELINES IN A TERTIARY HOSPITAL IN NIGERIA”. International Journal of Pharmacy and Pharmaceutical Sciences, Vol. 12, no. 8, June 2020, pp. 106-10, doi:10.22159/ijpps.2020v12i8.36452.
Section
Original Article(s)