DISEASE PREVENTION FUNCTIONAL FOODS FROM THE HIGH POTENTIAL MMP-2 INHIBITION ACTIVITY OF PINEAPPLE JUICE GRANULE
Keywords:Disease prevention, Functional food, Granules, MMP-2 inhibition, Pineapple juice
Objective: This study aimed to compare total phenolic acid and protein contents as well as free radical scavenging, enzyme activities of fresh and fermented pineapple juice.
Methods: The dried pineapple juice, prepared by freeze-drying and granulation method, with high bioactive compounds (total phenolic acid and protein contents) and biological activities (scavenging and enzyme activities) from fresh and fermented pineapple juice was developed and evaluated. The selected granules were evaluated for their stability at the 3 different temperatures for 3 mo. The pineapple juice granules were tested for the non-cytotoxic concentration by the SRB assay and Matrix metalloproteinase 2 (MMP-2) inhibition activity on human skin fibroblast.
Results: The pineapple juice granules, the single-coated granules of pineapple juice showed a higher percentage of yield but lower biological contents and activities than that triple-coated granules. The triple-coated granules of pineapple juice exhibited the highest total protein content (1.53±0.10 mg Bovine serum albumin equivalent (BSAE)) with scavenging activity (51.15±5.94 %), and enzyme activity (4156.18±74.78 Casein digestion unit (CDU)/mg). For gelatinolytic activity on MMP-2, the freeze-dried powder and triple-coated granules of pineapple juice indicated the highest MMP-2 inhibition activity of 50.74% and 48.48%, respectively.
Conclusion: The triple-coated granules of pineapple juice could be served as a disease prevention functional food due to its easy operation, high total phenolic acid, and protein contents with high potential MMP-2 inhibition activity.
Farimin A, Nordin E. Physical properties of powdered roselle-pineapple juice-effects of maltodextrin. Nat Conf Postgrad Res 2009. p. 90-7.
Avallone S, Guiraud JP, Brillouet JM, Teisson C. Enzymatic browning and biochemical alterations in black spots of pineapple [Ananas comosus (L.) Merr.]. Curr Microbiol 2003;47:113-8.
Rattanathanalerk M, Chiewchan N, Srichumpoung W. Effect of thermal processing on the quality loss of pineapple juice. J Food Eng 2005;66:259-65.
Elkins ER, Lyon R, Huang C, Matthys A. Characterization of commercially produced pineapple juice concentrate. J Food Compos Anal 1997;10:285-98.
Wen L, Wrolstad R. Phenolic composition of authentic pineapple juice. J Food Sci 2002;67:155-61.
Menon A, Priya VV, Gayathri R. Preliminary phytochemical analysis and cytotoxicity potential of pineapple extract on oral cancer cell lines. Asian J Pharm Clin Res 2016;9:140-3.
Gawler JH. Constituents of canned Malayan pineapple juice I.-amino‐acids, non‐volatile acids, sugars, volatile carbonyl compounds and volatile acids. J Sci Food Agric 1962;13:57-61.
Dizy M, Martín Alvarez PJ, Cabezudo MD, Carmen Polo M. Grape, apple and pineapple juice characterisation and detection of mixtures. J Sci Food Agric 1992;60:47-53.
Saxena R, Arora V. Consumers of processed fruit and vegetable products: an analysis of buying behaviour. Indian Food Ind 1997;16:25-36.
Kadam DM, Samuel DV, Chandra P, Sikarwar HS. Impact of processing treatments and packaging material on some properties of stored dehydrated cauliflower. Int J Food Sci Technol 2008;43:1-14.
Tuyen CK, Nguyen MH, Roach PD. Effects of pre-treatments and air drying temperatures on colour and antioxidant properties of Gac fruit powder. Int J Food Eng 2011;7:44-50.
Tuyen CK, Nguyen MH, Roach PD. Effects of spray drying conditions on the physicochemical and antioxidant properties of the gac (Momordica cochinchinensis) fruit aril powder. J Food Eng 2010;98:385-92.
Tran TH, Nguyen MH, Zabaras D, Vu LT. Process development of gac powder by using different enzymes and drying techniques. J Food Eng 2008;85:359-65.
Beena Divya J, Kulangara Varsha K, Madhavan Nampoothiri K, Ismail B, Pandey A. Probiotic fermented foods for health benefits. Eng Life Sci 2012;12:377-90.
Di Cagno R, Minervini G, Rizzello CG, De Angelis M, Gobbetti M. Effect of lactic acid fermentation on antioxidant, texture, color and sensory properties of red and green smoothies. Food Microbiol 2011;28:1062-71.
Di Cagno R, Surico RF, Paradiso A, De Angelis M, Salmon JC, Buchin S, et al. Effect of autochthonous lactic acid bacteria starters on health-promoting and sensory properties of tomato juices. Int J Food Microbiol 2009;128:473-83.
Blümel J, Schmidt I, Willkommen H, Lower J. Inactivation of parvovirus B19 during pasteurization of human serum albumin. Transfusion 2002;42:1011-8.
Yeh CT, Yen GC. Effect of vegetables on human phenolsulfotransferases in relation to their antioxidant activity and total phenolics. Free Radical Res 2005;39:893-904.
Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 1976;72:248-54.
Tachibana Y, Kikuzaki H, Lajis NH, Nakatani N. Antioxidative activity of carbazoles from Murraya koenigii leaves. J Agric Food Chem 2001;49:5589-94.
Indrajeet A, Ojha S, Singh S, Chakravarty I, Kundu S. Extraction and purification of bromelain from pineapple fruit pulp and peel and comparative study of enzymatic activities. Int J Basic Appl Biol 2017;4:4-7.
Papazisis KT, Geromichalos GD, Dimitriadis KA, Kortsaris AH. Optimization of the sulforhodamine B colorimetric assay. J Immunol Methods 1997;208:151-8.
Kim S, Kim Y, Kim JE, Cho KH, Chung JH. Berberine inhibits TPA-induced MMP-9 and IL-6 expression in normal human keratinocytes. Phytomedicine 2008;15:340-7.
Manosroi A, Jantrawut P, Akihisa T, Manosroi W, Manosroi J. In vitro anti-aging activities of Terminalia chebula gall extract. Pharm Biol 2010;48:469-81.
Luximon Ramma A, Bahorun T, Crozier A. Antioxidant actions and phenolic and vitamin C contents of common mauritian exotic fruits. J Sci Food Agric 2003;83:496-502.
Cárnara M, Diez C, Torija E. Chemical characterization of pineapple juices and nectars. Principal components analysis. Food Chem 1995;54:93-100.
Kabasakalis V, Siopidou D, Moshatou E. Ascorbic acid content of commercial fruit juices and its rate of loss upon storage. Food Chem 2000;70:325-8.
Ramadan Hassanien MF. Total antioxidant potential of juices, beverages and hot drinks consumed in Egypt screened by DPPH in vitro assay. Grasas Aceites 2008;59:254-9.
Ruksiriwanich W, Sirithunyalug J, Boonpisuttinant K, Jantrawut P. Potent in vitro collagen biosynthesis stimulating and antioxidant activities of edible mushroom Volvariella volvacea aqueous extract. Int J Pharm Pharm Sci 2014;6:406-12.
Maisnam D, Rasane P, Dey A, Kaur S, Sarma C. Recent advances in conventional drying of foods. J Food Technol Pres 2017;1:25-34.
Sontakke M, Salve S. Solar drying technologies: a review. Int J Eng Sci 2015;4:29-35.
Mittal B, Mishra A, Srivastava A, Kumar S, Garg N. Chapter one-matrix metalloproteinases in coronary artery disease, in advances in clinical chemistry, G. S. Makowski, Editor. Elsevier; 2014. p. 1-72.
Malemud CJ, Chapter seven-matrix metalloproteinases and synovial joint pathology, in progress in molecular biology and translational science. RA Khalil. Editor. Academic Press; 2017. p. 305-25.
Sayanna D, Sudip M. Current developments on anti-inflammatory natural medicines. Asian J Pharm Clin Res 2018;11:61-5.
Ma Y, Iyer RP, de Castro Bras LE, Toba H, Yabluchanskiy A, Deleon-Pennell Kristine Y, et al. Chapter 4-cross talk between inflammation and extracellular matrix following myocardial infarction, in Inflam Heart Fail. WM Blankesteijn, R Altara. Editors. Academic Press: Boston; 2015. p. 67-79.
DeLeon Pennell KY, Meschiari CA, Jung M, Lindsey ML. Chapter two-matrix metalloproteinases in myocardial infarction and heart failure, in Prog Mol Biol Transla Sci. RA Khalil. Editor. Academic Press; 2017. p. 75-100.
Li Q, Withoff S, Verma IM. Inflammation-associated cancer: NF-κB is the lynchpin. Trends Immunol 2005;26:318-25.
Philchenkov A. Caspases: potential targets for regulating cell death. J Cell Mol Med 2004;8:432-44.
Zhang W, Wang F, Xu P, Miao C, Zeng X, Cui X, et al. Perfluorooctanoic acid stimulates breast cancer cells invasion and up-regulates matrix metalloproteinase-2/-9 expression mediated by activating NF-κB. Toxicol Lett 2014;229:118-25.