• SHIKHA KESHARVANI United Institute of Pharmacy, Naini, Allahabad, Uttar Pradesh, India 211010
  • PANKAJ KUMAR JAISWAL United Institute of Pharmacy, Naini, Allahabad, Uttar Pradesh, India 211010
  • ALOK MUKERJEE United Institute of Pharmacy, Naini, Allahabad, Uttar Pradesh, India 211010
  • AMIT KUMAR SINGH United Institute of Pharmacy, Naini, Allahabad, Uttar Pradesh, India 211010


Objective: The main objective of this study was to develop and evaluate the eudragit and HPMC coated metformin hydrochloride floating microspheres, in which HPMC helps in floating and eudragit as a coating material for a site-specific drug release in a controlled manner and the active moiety metformin used as anti-hyperglycemic agent.

Methods: The floating microsphere was prepared by the solvent evaporation method incorporating metformin as a model drug. The prepared floating microsphere were characterized for particle size, %yield, drug loading and entrapment efficiency, compatibility study, %buoyancy, surface morphology and In vitro drug release and release kinetics.

Results: The result metformin loaded floating microsphere was successfully prepared and the particle size range from 397±23.22 to 595±15.82 µm, the entrapment efficiency range from 83.49±1.33 to 60.02±1.65% and drug loading capacity range from 14.3±0.54 to 13.31±0.47% and %buoyancy range from 85.67±0.58 to 80.67±1.15%. The FT-IR and X-RD analysis confirmed that no any interaction between drug and excipient, and surface morphology confirmed those particles are sphere. The floating microsphere show maximum 96% drug release in pH 0.1N HCL and follow the Korsmeyer peppas model of the super case-2 transport mechanism.

Conclusion: These results suggest that metformin loaded floating microspheres could be retain in stomach for long time and give site specific drug release in controlled manner.

Keywords: Floating capability, Therapeutic Response, Eudragit and Metformin


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How to Cite
KESHARVANI, S., P. K. JAISWAL, A. MUKERJEE, and A. K. SINGH. “FORMULATION AND EVALUATION OF METFORMIN HYDROCHLORIDE LOADED FLOATING MICROSPHERES”. International Journal of Pharmacy and Pharmaceutical Sciences, Vol. 12, no. 2, Dec. 2019, pp. 74-82, doi:10.22159/ijpps.2020v12i2.35099.
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