FORMULATION AND EVALUATION OF METFORMIN HYDROCHLORIDE LOADED FLOATING MICROSPHERES

  • SHIKHA KESHARVANI United Institute of Pharmacy, Naini, Allahabad, Uttar Pradesh, India 211010
  • PANKAJ KUMAR JAISWAL United Institute of Pharmacy, Naini, Allahabad, Uttar Pradesh, India 211010
  • ALOK MUKERJEE United Institute of Pharmacy, Naini, Allahabad, Uttar Pradesh, India 211010
  • AMIT KUMAR SINGH United Institute of Pharmacy, Naini, Allahabad, Uttar Pradesh, India 211010

Abstract

Objective: The main objective of this study was to develop and evaluate the eudragit and HPMC coated metformin hydrochloride floating microspheres, in which HPMC helps in floating and eudragit as a coating material for a site-specific drug release in a controlled manner and the active moiety metformin used as anti-hyperglycemic agent.


Methods: The floating microsphere was prepared by the solvent evaporation method incorporating metformin as a model drug. The prepared floating microsphere were characterized for particle size, %yield, drug loading and entrapment efficiency, compatibility study, %buoyancy, surface morphology and In vitro drug release and release kinetics.


Results: The result metformin loaded floating microsphere was successfully prepared and the particle size range from 397±23.22 to 595±15.82 µm, the entrapment efficiency range from 83.49±1.33 to 60.02±1.65% and drug loading capacity range from 14.3±0.54 to 13.31±0.47% and %buoyancy range from 85.67±0.58 to 80.67±1.15%. The FT-IR and X-RD analysis confirmed that no any interaction between drug and excipient, and surface morphology confirmed those particles are sphere. The floating microsphere show maximum 96% drug release in pH 0.1N HCL and follow the Korsmeyer peppas model of the super case-2 transport mechanism.


Conclusion: These results suggest that metformin loaded floating microspheres could be retain in stomach for long time and give site specific drug release in controlled manner.

Keywords: Floating capability, Therapeutic Response, Eudragit and Metformin

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KESHARVANI, S., P. K. JAISWAL, A. MUKERJEE, and A. K. SINGH. “FORMULATION AND EVALUATION OF METFORMIN HYDROCHLORIDE LOADED FLOATING MICROSPHERES”. International Journal of Pharmacy and Pharmaceutical Sciences, Vol. 12, no. 2, Dec. 2019, pp. 74-82, doi:10.22159/ijpps.2020v12i2.35099.
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