IMMUNOMODULATORY, ANTICANCEROUS & ANTIOXIDANTACTIVITIES OF CYCLEA PELTATA (LAM.) HOOK.F. & THOMSON

  • SONY JAYARAMAN Department of Biotechnology and Microbiology, Kannur University, Thalassery Campus, Kannur 670661, Kerala, India
  • E. JAYADEVI VARIYAR Department of Biotechnology and Microbiology, Kannur University, Thalassery Campus, Kannur 670661, Kerala, India

Abstract

Introduction: Cyclea peltata (Lam.) Hook.f. & Thomson is an important plant listed in Ayurveda. The plants are used in digestive, diuretic and inflammatory disorders.


Aim: The present study was to study the immunomodulatory, anticancerous and antioxidative properties of the fraction isolated from Cyclea peltata.


Methods: The immunomodulatory activity was evaluated in lymphocytes and THP-1 macrophage cell lines. The anticancer activity of the fraction was determined by MTT assay. The antioxidant activity was evaluated by DPPH and total antioxidant assays.


Results: The fraction showed the presence of flavanoids which induced lymphocyte proliferation and also could induce nitrite production in THP-1 cell lines at 1mg/ml. It also exhibited good anticancerous activity at 100 μg/ml after 48h of incubation.  The antioxidant activity was less at this concentration and was found to be equivalent to 79± 0.03 μg/ml of ascorbic acid.


Conclusion: The fraction containing flavonoid, isolated from Cyclea peltata have shown to have good immunomodulatory, antioxidant and anticancerous property.

Keywords: Immunomodulation, Anticancer, Cyclea peltata (Lam.) Hook. f. and Thomson, Antioxidant, Lymphocyte, Macrophage

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Author Biography

E. JAYADEVI VARIYAR, Department of Biotechnology and Microbiology, Kannur University, Thalassery Campus, Kannur 670661, Kerala, India

Assistant Professor

Department of Biotechnology and Microbiology

School of Life Sceince

Kannur University

Thalassery Campus

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JAYARAMAN, S., and E. J. VARIYAR. “IMMUNOMODULATORY, ANTICANCEROUS & ANTIOXIDANTACTIVITIES OF CYCLEA PELTATA (LAM.) HOOK.F. & THOMSON”. International Journal of Pharmacy and Pharmaceutical Sciences, Vol. 11, no. 10, Oct. 2019, pp. 40-46, doi:10.22159/ijpps.2019v11i10.35248.
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