A CRITICAL LITERATURE REVIEW AND AUDIT OF REAL WORLD DATA TO INFORM THE RELATIONSHIP BETWEEN MENTAL ILL-HEALTH AND TYPE-2 DIABETES FAVOURABLE PROGNOSIS

  • NASREEM BIBI School of Pharmacy, University of Wolverhampton, Wulfruna Street, Wolverhampton, WV1 1LY, United Kingdom
  • BAHTA WARA School of Pharmacy, University of Wolverhampton, Wulfruna Street, Wolverhampton, WV1 1LY, United Kingdom
  • SAQIB MUGHAL School of Pharmacy, University of Wolverhampton, Wulfruna Street, Wolverhampton, WV1 1LY, United Kingdom
  • HANA MORRISSEY School of Pharmacy, University of Wolverhampton, Wulfruna Street, Wolverhampton, WV1 1LY, United Kingdom https://orcid.org/0000-0001-9752-537X
  • PATRICK BALL School of Pharmacy, University of Wolverhampton, Wulfruna Street, Wolverhampton, WV1 1LY, United Kingdom http://orcid.org/0000-0001-8918-2119

Abstract

Objective: The aim of this scoping study was to identify gaps in the current literature and understand the T2DM and MIH comorbidity trends in the local population from the West Midlands, UK to inform future studies.


Methods: This project was a scoping study of two parts; a critical review and a clinical audit. A thematic approach was used to group studies based on their overall study outcome. The clinical audit data was used to compare the local patient population to the patterns identified in the literature reviewed.


Results: The reviewed studies reported a relationship between T2DM control and both depression and anxiety, but did not agree on its significance. The clinical audit of 71 patients diagnosed with T2DM showed that 73% of males presented with poor diabetes control (HbA1c>7) compared to females (46%). Conversely, females exhibited a higher prevalence of MIH (45%) compared to males (31%).


Conclusion: From both this audit of the literature and local data, it remains unclear whether mental-ill health is a major driver for medication non-adherence behaviour and uncontrolled diabetes. Further studies are recommended to further understand this comorbidity.

Keywords: Anxiety, Depression, Type 2 diabetes mellitus, Mental ill-health, Real-world data

Downloads

Download data is not yet available.

Author Biographies

NASREEM BIBI, School of Pharmacy, University of Wolverhampton, Wulfruna Street, Wolverhampton, WV1 1LY, United Kingdom

GP independent prescriber pharmacist

BAHTA WARA, School of Pharmacy, University of Wolverhampton, Wulfruna Street, Wolverhampton, WV1 1LY, United Kingdom

Pharmacist

SAQIB MUGHAL, School of Pharmacy, University of Wolverhampton, Wulfruna Street, Wolverhampton, WV1 1LY, United Kingdom

MEDICAL DOCTOR

HANA MORRISSEY, School of Pharmacy, University of Wolverhampton, Wulfruna Street, Wolverhampton, WV1 1LY, United Kingdom

Reader in Clinical Pharmacy

PATRICK BALL, School of Pharmacy, University of Wolverhampton, Wulfruna Street, Wolverhampton, WV1 1LY, United Kingdom

Professor of Pharmacy Practice

References

1. Bibi N, Morrissey H, Ball PA. A service improvement opportunity for pharmacist independent prescribers? a literature review examining the relationship between poor diabetes control and the co-existence of mental health issues. Int J Curr Pharm Res 2019;11:6-10.
2. Morrissey H, Ball PA, Jackson DM, Pilotto LSJ. Use of chronic disease management algorithms in Australian community pharmacies. Res Soc Admin Pharm 2015;11:176-96.
3. American Psychiatric Association education. What is Depression? Available from: https://www.psychiatry.org/patients-families/depression/what-is-depression. [Last accessed on 20 Sep 2019].
4. National Health Services. Overview Generalised anxiety disorders in adults. Available from: https://www.nhs.uk/ conditions/generalised-anxiety-disorder/>. [Last accessed on 20 Sep 2019].
5. Smith KJ, Beland M, Clyde M, Gariepy G, Page V, Badawi G, et al. Association of diabetes with anxiety: a systematic review and meta-analysis. J Psychosom Res 2013;742:89-99.
6. Lustman PJ, Griffuth LS, Clouse RE, Cryer PE. Psychiatric illness in diabetes mellitus. Relationship to symptoms and glucose control. J Nerv Ment Dis 2016;174:736-42.
7. Trento M, Raballo M, Trevisan J, Sicuro P, Passera L, Cirio L, et al. Depression in diabetes mellitus: a comprehensive review. Hippokratia 2012;6:205–14.
8. Jia Z, Li X, Yaun X, Zhang B, Yaun L, Zhao J, et al. Depression is associated with diabetes status of family members NHANES (1999-2016). J Affect Dis 2019;249:121-6.
9. Gonzalez JS, Safren SA, Cagliero E, Wexler DJ, Delahanty L, Wittenberg E, et al. Depression, self-care, and medication adherence in type2 diabetes. Diabetes Care 2007;30:2222-7.
10. Engum A. The role of depression and anxiety in the onset of diabetes in a large population-based study. J Psychosom Res 2007;62:31-8.
11. Safren SA, Gonzalez JS, Wexler DJ, Psaros C, Delahanty LM, Blashill AJ, et al. A randomized controlled trial of cognitive-behavioral therapy for adherence and depression (CBT-AD) in patients with uncontrolled type 2 diabetes. Diabetes Care 2014;37:625-33.
12. Pan A, Lucas M, Sun Q, Van Dam RM, Franco OH, Manson JE, et al. Bidirectional association between depression and type 2 diabetes mellitus in women. Arch Intern Med 2010;170:1884-91.
13. Mezuk B, Chen Y, Yu C, Guo Y, Bian Z, Collins R, et al. Depression, anxiety, prevalent diabetes in the chinses population: findings front the china kadoorie biobank of 0.5 million people. J Psychosom Res 2013;75:511-7.
14. Naicker K, Johnson JA, Skogen JC, Manuel D, Overland S, Sivertsen B, et al. Type 2 diabetes and comorbid symptoms of depression and anxiety: longitudinal associations with mortality risk. Diabetes Care 2017;40:352–8.
15. Khuwaja AK, Lalani S, Dhanani R, Azam IS, Rafique G, White F. Anxiety and depression among outpatients with type 2 diabetes: a multi-center study of prevalence and associated factors. Diabetes Metab Synd 2010;2:72.
16. Edwards LE, Mezuk B. Anxiety and risk of type 2 diabetes: evidence from the baltimore epidemiologic catchment area study. J Psychosom Res 2012;73:418–23.
17. Ayman A, Al Hayek, Asirvatham A Robert, Aus A Alzaid. Impact of an education program on anxiety, depression, glycaemic control and adherence to self-care and medication in type 2 diabetes. J Fam Commun Med 2013;20:77-82.
18. Colins MM, Corcoran P, Perry IJ. Anxiety and depression symptoms in patients with diabetes. Diabetes Med 2009;26:153-61.
19. Lunghi C, Moisan J, Gregoire JP, Guenette L. Incidence of depression and associated factors in patients with type 2 diabetes in quebec, canada: a population-based cohort study. Medicine (Baltimore) 2016;95:e3514.
20. Ivanova A, Nitka D, Schmitz N. Epidemiology of antidepressant medication use in the canadian diabetes population. Can J Diabetes 2010;45:911-9.
21. Rachdi C, Damak R, Fekih Romdhane F, Ouertani H, Cheour M. Impact of sertraline on weight, waist circumference and glycaemic control: a prospective clinical trial on depressive diabetic type 2 patients. Prim Care Diabetes 2019;13:57-62.
22. Pan A, Sun Q, Okereke OI, Rexrode KM, Rubin RR, Lucas M, et al. Use of antidepressant medication and risk of type 2 diabetes: results from three cohorts of US adults. Diabetologia 2012;55:63-72.
23. Roopan S, Larsen ER. Use of antidepressants in patients with depression and comorbid diabetes mellites: a systemic review. Acta Neuropsychiatrica 2017;29:127-39.
24. Kivimaki M, Hamr M, Batty GD, Geddes JR, Tabak AG, Pentti J, et al. Antidepressants medication use, weight gain, and risk of type2 diabetes: a population-based study. Diabetes Care 2010;33:2611-6.
25. Ganasegeran K, Renganathan P, Abdul Manaf R, Abdo Radman S, Dubai A. Factors associated with anxiety and depression among type 2 diabetes outpatients in Malaysia: a descriptive cross-sectional single-center study. Br Med J Open 2014;4:e004794.
26. Petrak F, Herpertz S, Albus C, Hermanns N, Hiemke C, Hiller W, et al. Cognitive Behaviour therapy versus sertraline in patients with depression and poorly controlled diabetes: diabetes and depression (DAD) study: a randomized controlled multicentre trial. Diabetes Care 2015;38:767-75.
Statistics
69 Views | 51 Downloads
Citatons
How to Cite
BIBI, N., B. WARA, S. MUGHAL, H. MORRISSEY, and P. BALL. “A CRITICAL LITERATURE REVIEW AND AUDIT OF REAL WORLD DATA TO INFORM THE RELATIONSHIP BETWEEN MENTAL ILL-HEALTH AND TYPE-2 DIABETES FAVOURABLE PROGNOSIS”. International Journal of Pharmacy and Pharmaceutical Sciences, Vol. 12, no. 2, Dec. 2019, pp. 43-47, doi:10.22159/ijpps.2020v12i2.36393.
Section
Original Article(s)