THERAPEUTIC APPROACH TO CONCURRENT PCP AND PULMONARY TB IN PEOPLE LIVING WITH HIV/AIDS WITH VARIOUS DRUG HYPERSENSITIVITY REACTIONS

  • KETUT SURYANA Department of Internal Medicine at Wangaya Hospital in Denpasar, Bali, Indonesia

Abstract

Pneumocystis Carinii Pneumonia (PCP) and Pulmonary Tuberculosis (PTB) are the most frequent Opportunistic Infection (OI) in People living with HIV/AIDS (PLWHA), especially whose CD4 counts<200 cells/mL. There is no pathognomonic sign and symptom of pneumocystis, radiographic imaging (chest radiograph) and blood examination. An intractable microorganism cannot be isolated or sustained in culture. The diagnosis of PCP is complicated, based on the presumptive diagnosis. PCP should be treated optimally as soon as possible in order not to be fatal. We report a complicated case of a female 26 y-old, diagnosed with HIV infection on Highly Active Anti Retro Viral Therapy (HAART), PTB on Anti Tuberculosis Drugs (ATD) concurrent with PCP. She also has a history of various Drug Hypersensitivity Reactions (DHR) include Rifampycin, Ciprofloxacin and Cotrimoxazole. DHR is unpredictable, and Clindamycin and Primaquin are the recommended alternative drugs for PCP, the strategic therapy is by Desensitization Protocols.

Keywords: People living with HIV/AIDS, Pneumocystis Carinii Pneumonia, Pulmonary Tuberculosis, Drug Hypersensitivity Reactions

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SURYANA, K. “THERAPEUTIC APPROACH TO CONCURRENT PCP AND PULMONARY TB IN PEOPLE LIVING WITH HIV/AIDS WITH VARIOUS DRUG HYPERSENSITIVITY REACTIONS”. International Journal of Pharmacy and Pharmaceutical Sciences, Vol. 12, no. 5, Mar. 2020, pp. 85-89, doi:10.22159/ijpps.2020v12i5.37247.
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