Cefpodoxime Proxetil Fast Dissolving Tablets: Comparative Study
The demands of the development of FDTs are increased enormously as it has a great impact on patient compliance. Fast disintegrating tablets (FDTs) are gaining more popularity because drug gets dissolved or easily disintegrated in the mouth within a sec without the need of water. In the present investigation, fast dissolving tablets of cefpodoxime proxetil were formulated using superdisintegrants to impart fast disintegration. In the current study, 12 formulations of fast dissolving tablets of cefpodoxime proxetil were formulated using two different approaches namely direct compression and sublimation. Three different superdisintegrants viz., croscarmellose sodium, sodium starch glycolate, and crospovidone were used in a different concentration in all the respective formulations. The final powder blend was subjected for the pre-compression evaluation like bulk density, tapped density, the angle of repose, Carr’s index, Hausner’s ratio. All the formulations were evaluated for post-compression parameters weight variations, thickness, size and shape, disintegration time, hardness, friability, water absorption ratio, wetting time and in-vitro dissolution study. Stability studies were also evaluated for the best formulations as per ICH guidelines. Finally, results were statistically analyzed by the application of one way ANOVA test and t-test. Among all the formulations of different approaches, formulation CP4 containing 6% crospovidone as a super disintegrant was showed the best results. In vitro dissolution data revealed that formulation CP4 showed 99.387±0.270% drug release within 15 min. The optimized formulation was further subjected to comparative in-vitro study with two marketed formulation of different brands resulting CP4 showed 99.587 ± 0.142 % drug release within 15 min as compared to a marketed formulation which showed 88.907 ± 0.566 % and 92.627 ± 0.719 % within 15 min. All the data of all formulations is shows that direct compression approach is the best approach for developing the fast dissolving tablets to enhance the onset of section and bioavailability.
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