ANTIEMETIC ACTIVITIES OF INDONESIAN STINGLESS BEE PROPOLIS ON EMETIC INDUCED BY ANTI-TUBERCULOSIS DRUGS

  • MAHANI Food Technology Department, Faculty of Agric, Industrial Technology, Universitas Padjadjaran, Indonesia, Community Nutrition Department, Faculty of Human Ecology, IPB University, Indonesia
  • FIRMANSYAH FATURACHMAN Food Technology Department, Faculty of Agric, Industrial Technology, Universitas Padjadjaran, Indonesia
  • MICHELLE Food Technology Department, Faculty of Agric, Industrial Technology, Universitas Padjadjaran, Indonesia
  • ELAZMANAWATI LEMBONG Food Technology Department, Faculty of Agric, Industrial Technology, Universitas Padjadjaran, Indonesia
  • AHMAD SULAEMAN Community Nutrition Department, Faculty of Human Ecology, IPB University, Indonesia
  • HARDINSYAH Community Nutrition Department, Faculty of Human Ecology, IPB University, Indonesia
  • NUNUNG NURJANAH National Institute of Health Research and Development, Indonesian Ministry of Health Indonesia
  • SUNARNO National Institute of Health Research and Development, Indonesian Ministry of Health Indonesia
  • KAMBANG SARIADJI National Institute of Health Research and Development, Indonesian Ministry of Health Indonesia

Abstract

Objective: This study aims to determine the antiemetic potential of stingless bee propolis in reducing the prevalence of nausea due to consumption of Anti-Tuberculosis Drugs (ATD) in Tuberculosis patients and to identify phytochemical compounds that act as an antiemetic in propolis.


Methods: The stingless bee propolis used was Wallacetrigona incisa from South Sulawesi. The clinical testing used the randomized controlled trial, randomization using permuted block randomization consisting of one positive control group and two treatment groups. The active components analyzed using Gas Chromatography-Mass Spectrometer (GC-MS) pyrolyzer.


Results: This study found that the measurement at week 0 obtained the mean value of nausea per week for each group P0 (Placebo), P1 (Propolis 6%), and P2 (Propolis 30%) were respectively 2.14; 1.5 and 5.2 events/week, at week 8 the prevalence of nausea by 2.0; 1.0; and 1.6 events/week, and week 24 the prevalence of nausea by 3.0; 0; and 0 events/week. There are 11 compounds with concentrations above 1% that act as antiemetic compounds either through direct and indirect mechanism with a total concentration reaches 75,47%.


Conclusion: Based on all determinant parameters, propolis of Wallacetrigona incisa species from South Sulawesi has antiemetic activity and can reduce the prevalence of emetic induced by ATD consumption in pulmonary TB patients.

Keywords: Antiemetic, Antiemetic Compounds, Anti-Tuberculosis Drugs, Stingless Bee Propolis, Nausea

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MAHANI, F. FATURACHMAN, MICHELLE, E. LEMBONG, A. SULAEMAN, HARDINSYAH, N. NURJANAH, SUNARNO, and K. SARIADJI. “ANTIEMETIC ACTIVITIES OF INDONESIAN STINGLESS BEE PROPOLIS ON EMETIC INDUCED BY ANTI-TUBERCULOSIS DRUGS”. International Journal of Pharmacy and Pharmaceutical Sciences, Vol. 13, no. 4, Apr. 2021, pp. 39-44, doi:10.22159/ijpps.2021v13i4.39618.
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