• EMELIA OPPONG BEKOE Department of Pharmacognosy and Herbal Medicine, School of Pharmacy, College of Health Sciences, University of Ghana
  • MICHAEL WIAFE-KWAGYAN Department of Plant and Environmental Biology, College of Basic and Applied Sciences, University of Ghana
  • JOYCELYN GAYSI Department of Pharmacognosy and Herbal Medicine, School of Pharmacy, College of Health Sciences, University of Ghana


Objective: This study sought to preliminarily investigate the inhibitory effect of metabolites of Aspergillus chevalieri and Trichoderma harzianum on a number of pathogenic bacteria.

Methods: The agar well diffusion method was employed to determine the antimicrobial activity of the fungal metabolites. The test microorganisms were Enterococcus faecalis, methicillin-resistant Staphylococcus aureus (MRSA), Salmonella typhi, Escherichia coli and Pseudomonas aeruginosa.

Results: Both metabolites had broad-spectrum antibacterial activity. All the test organisms were susceptible to the A. chevalieri metabolites except for S. typhi. Both S. typhi and E. faecalis were however not susceptible to T. harzianum metabolites. P. aeruginosa was highly susceptible to both metabolites with the highest zone of inhibition of 26 mm for the stock metabolite. This activity was comparable to the standard, 10 µg/ml of ciprofloxacin.

Conclusion: Metabolites of A. chevalieri and T. harzianum exhibited broad-spectrum activity, and this can be exploited as a source for novel antibiotics.

Keywords: Antibacterial activity, Antibiosis, Aspergillus chevalieri, Trichoderma harzianum, Culture metabolites


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How to Cite
BEKOE, E. O., M. WIAFE-KWAGYAN, and J. GAYSI. “ANTIBACTERIAL ACTIVITY OF THE METABOLITES OF ASPERGILLUS CHEVALIERI AND TRICHODERMA HARZIANUM ”. International Journal of Pharmacy and Pharmaceutical Sciences, Vol. 13, no. 2, Feb. 2021, pp. 67-70, doi:10.22159/ijpps.2021v13i2.39654.
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