• Emelia Oppong Bekoe University of Ghana
  • Michael Wiafe-Kwagyan University of Ghana
  • Joycelyn Gaysi University of Ghana


The rapid emergence of resistant bacteria has endangered the efficacy of once very effective antibiotics. Due to this phenomenon, there is a need to explore all possibilities to develop new antibiotics. Antibiosis which is the inhibition of one microorganism by another through chemical means is a natural process that has enabled humankind to obtain antibiotics for the treatment of several infections.

Objective: This study sought to preliminarily investigate the inhibitory effect of metabolites of Aspergillus chevalieri and Trichoderma harzianum on a number of pathogenic bacteria.

Methods: The agar well diffusion method was employed to determine the antimicrobial activity of the metabolites against Enterococcus faecalis, methicillin-resistant Staphylococcus aureus (MRSA), Salmonella typhi, Escherichia coli and Pseudomonas aeruginosa..

Results: Both metabolites had broad-spectrum antibacterial activity. All the test organisms were susceptible to the A. chevalieri metabolites except for S. typhi. T. harzianum metabolite was however not active against S. typhi and E. faecalis. Both metabolites were highly active against P. aeruginosa.

Conclusion: Metabolites of A. chevalieri and T. harzianum exhibited broad-spectrum activity, and this can be exploited to produce antibiotics.

Keywords: antbacterial activity, antibiosis, Aspergillus chevalieri, Trichoderma harzianum, culture metabolites


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Author Biographies

Michael Wiafe-Kwagyan, University of Ghana

Department of Plant and Environmental Biology, College of Basic and Applied Sciences, University of Ghana

Senior Lecturer

Joycelyn Gaysi, University of Ghana

Department of Pharmacognosy and Herbal Medicine, University of Ghana



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How to Cite
Oppong Bekoe, E., M. Wiafe-Kwagyan, and J. Gaysi. “ANTIBACTERIAL ACTIVITY OF THE METABOLITES OF ASPERGILLUS CHEVALIERI AND TRICHODERMA HARZIANUM”. International Journal of Pharmacy and Pharmaceutical Sciences, Vol. 13, no. 2, Jan. 2021,
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