Efficacy of catfish (Pangasius hypophthalmus) oil to overcome stunting by reducing inflammatory condition.
Objective : This study aimed to evaluate effect of catfish (Pangasius hypophthalmus) oil on hs-CRP and transthyretin levels of undernourished Wistar rats.
Methods : Thirty male Wistar rats were divided into five equal groups. Healthy control (KN) is normal rats that consumed standard diet only, negative control (K-) is undernourished rats that consumed protein free diet only and undernourished rats that consumed protein free diet and catfish (Pangasius hypophthalmus) oil at doses 0.020 ml/200 g-body-weight/d, 0.040 ml/200 g-body-weight/d and 0.060 ml/200 g-body-weight/d were classified to P1, P2 and P3 groups, respectively.
Results : Treatment of catfish (Pangasius hypophthalmus) oil on P3 group significantly increase body weight of rats (p<0,05) compare to K-, P1 and P2 groups. There were significant difference of hs-CRP levels in P1, P2 and P3 groups (p<0,05) compare to K-. Hs-CRP levels in P1, P2 and P3 groups were lower compare to K- but higher than KN. The mean value of hs-CRP levels in the P3 group (dose 0.060 ml/200 g-body-weight/d) was lower than the other treatment groups. Otherwise, there were no significant difference of TTR levels in P1, P2 and P3 group (p>0,05) compared to K-.
Conclusion : The present study showed that catfish (Pangasius hypophthalmus) oil have potential effect to increase body weight, reduce inflammatory biomarker (hs-CRP) levels but have no effect to increase TTR levels in undernourished Wistar rats.
Keywords : catfish oil, Pangasius hypophthalmus, stunting, undernourished, hs-CRP, transthyretin.
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