Efficacy of catfish (Pangasius hypophthalmus) oil to overcome stunting by reducing inflammatory condition.

  • Sepsina Reski Department of Nutrition Science, Diponegoro University https://orcid.org/0000-0002-9274-356X
  • Etisa Adi Murbawani Deparment of Nutrition Science, Faculty of Medicine, Diponegoro University
  • Farmaditya Eka Putra Mundhofir Department of Histology, Faculty of Medicine, Diponegoro University
  • Yora Nindita Department of Pharmacology and Therapy, Faculty of Medicine, Diponegoro University
  • Muflihatul Muniroh Department of Physiology, Faculty of Medicine, Diponegoro University
  • Fronthea Swastawati Department of Fisheries Post Harvest Technology Marine Science, Diponegoro University
  • Endang Mahati Department of Pharmacology and Therapy, Faculty of Medicine, Diponegoro University

Abstract

Objective : This study aimed to evaluate effect of catfish (Pangasius hypophthalmus) oil on  hs-CRP and transthyretin levels of undernourished Wistar rats.


Methods : Thirty male Wistar rats were divided into five equal groups. Healthy control  (KN) is normal rats that consumed standard diet only, negative control (K-) is undernourished rats that consumed protein free diet only and undernourished rats that consumed protein free diet and catfish (Pangasius hypophthalmus)  oil at doses 0.020 ml/200 g-body-weight/d, 0.040 ml/200 g-body-weight/d  and 0.060 ml/200 g-body-weight/d  were classified to P1, P2 and P3 groups, respectively.


Results : Treatment of catfish (Pangasius hypophthalmus) oil on P3 group significantly increase body weight of rats (p<0,05) compare to K-, P1 and P2 groups. There were significant difference of hs-CRP levels in P1, P2 and P3 groups (p<0,05) compare to K-. Hs-CRP levels in P1, P2 and P3 groups were lower compare to K- but higher than KN. The mean value of hs-CRP levels in the P3 group (dose 0.060 ml/200 g-body-weight/d) was lower than the other treatment groups. Otherwise, there were no significant difference of TTR levels in P1, P2 and P3 group (p>0,05) compared to K-.


Conclusion : The present study showed that catfish (Pangasius hypophthalmus) oil have potential effect to increase body weight, reduce inflammatory biomarker (hs-CRP) levels but have no effect to increase TTR levels in undernourished Wistar rats.


Keywords : catfish oil, Pangasius hypophthalmus, stunting, undernourished, hs-CRP, transthyretin.


 

Keywords: inflammatory

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Sepsina Reski, E. A. Murbawani, F. E. P. Mundhofir, Y. Nindita, M. Muniroh, F. Swastawati, and E. Mahati. “Efficacy of Catfish (Pangasius Hypophthalmus) Oil to Overcome Stunting by Reducing Inflammatory Condition.”. International Journal of Pharmacy and Pharmaceutical Sciences, Vol. 13, no. 5, Mar. 2021, doi:10.22159/ijpps.2021v13i5.40357.
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