Formulation and evaluation of floating microspheres of ciprofloxacin by solvent evaporation method using different polymers.

  • KAUSLYA ARUMUGAM Department of Pharmaceutics, Pune District Education Association's Seth Govind Raghunath Sable College of Pharmacy, Saswad, Pune, Maharashtra, India
  • PAYAL D. BORAWAKE Department of Pharmaceutics, Pune District Education Association’s, Seth Govind Raghunath Sable College of Pharmacy, Saswad, Pune, Maharashtra, India
  • JITENDRA V. SHINDE Department of Pharmaceutics, Pune District Education Association’s, Seth Govind Raghunath Sable College of Pharmacy, Saswad, Pune, Maharashtra, India

Abstract

Objective:  The main intention of this research was to formulate and evaluate floating microspheres of Ciprofloxacin using different polymers to prolong gastric residence time.


Methods: The microspheres were formulated by the solvent evaporation method using different ratio of polymers like Carbopol 940, Ethyl cellulose and Hydroxy Propyl Methyl Cellulose K4M. Further the floating microspheres were evaluated for micromeritic properties like bulk density, tapped density, angle of repose, etc., percentage yield, Particle size, Entrapment efficiency, floating capacity, in-vitro  drug release study, release kinetics, drug content, swelling index and Fourier Transform Infrared Spectroscopy (FTIR) (Compatibility studies).


Results: The ciprofloxacin microspheres showed good flowing property. The particle size ranged from 258.1±2.21µm to 278±2.86µm and entrapment efficiency ranged from 63.17±0.43% to 89.90±1.32%. The IR spectrum revealed that there was no interaction between the drug and polymer. F7 formulation was found to be the best formulation. Drug release was to found to be 90.70±0.89% i.e. in the controlled manner at the end of 10 h.


Conclusion: The floating microspheres were prepared successfully and the results clearly stated that prepared ciprofloxacin microspheres may be safe and effective controlled drug delivery over an extended period of time which can increase bioavailability, patient compliance and decrease dosing frequency.   

Keywords: Ciprofloxacin, Solvent evaporation method, Carbopol 940, Ethyl cellulose, Hydroxy Propyl Methyl Cellulose K4M, Floating Microspheres.

Downloads

Download data is not yet available.

References

1. Jalodiya S, Gupta MK and Jain NK. Formulation, development and evaluation of floating microspheres of acyclovir. J Drug Delivery Ther 2019;9(4):967-973.
2. Saxena A, Gaur K, Singh V, Singh RK and Dashora A. Floating microspheres as drug delivery system. American Journal of Pharmacy and Pharmaceutical Sciences 2014;1(2):27-36.
3. Jagtap YM, Bhujbal RK and Ranpise NS. Floating microspheres: a review. Brazilian Journal of Pharmaceutical sciences 2012; 48(1):18-30.
4. Vidyavathi M and Srividya G. A review on ciprofloxacin: Dosage form perspective. Int J Appl Pharm 2018;10(4):6-10.
5. Prasad AR, Ratna JV. Development and validation of a simple UV-Spectrophotometric method for the determination of ciprofloxacin HCl present in taste masked drug resin complex. Int J Appl Pharm 2018;10(3):37-41.
6. Shailendra SS, Kavalapure R, Palled MS and Alegaon SG. Development and validation of UV-Spectrophotometric method for determination of ciprofloxacin and curcumin in bulk powder. Int J Pharm Sci Res 2020;11(3):1161-1166.
7. Chandra MS, Dharan SS and Athira A. Formulation and evaluation of gastroretentive floating microballoons containing selected anti-ulcer drug. J Pharm Sci Res 2021;13(1):49-63.
8. Chouhan M, Chundawat AVS and Chauhan CS. Development and characterization of floating microspheres of esomeprazole magnesium trihydrate by solvent evaporation method. Int J Pharm Sci Res 2017;8(2):689-697.
9. Durgapal S, Mukhopadhyay S and Goswami L. Preparation, characterization and evaluation of floating microparticles of ciprofloxacin. Int J Appl Pharm 2017;9(1):1-8.
10. Subramanyam CVS: A Text Book of Physical Pharmaceutics. Vallabh Prakashan, Second edition 2000.
11. Bangale GS, Shinde GV and Rajesh KS. Development and evaluation of microballons based extended release drug delivery system for hypertension therapy. Global Journal of Pharmacy and Pharmaceutical Sciences 2019;7(4):1-11.
12. Purohit KK and Garud N. Formulation and evaluation of floating microspheres of losartan potassium using sodium alginate and HPMC by solvent evaporation method. J Drug Delivery Ther 2019;9(1):60-66.
13. Aqdas S, Rao UM, Sirisha B, Kumar PR, Lakshmi PV and Ajitha M. Formulation and in-vitro evaluation of stomach specific floating microspheres of simvastatin. Int Res J Pharm 2014;5(11):827-833.
14. Anjali DN, Vijendar C, Goud AK, Anil KD, Khaja M and Anil A. Preparation and evaluation of floating microspheres of cefdinir in treatment of otitis media and respiratory tract infections. J Pharmacovigilance 2016;4(1):1-4.
15. Josephine LJJ, Mehul RT, Wilson B, Shanaz B and Bincy R. Formulation and in-vitro evaluation of floating microspheres of anti-retro viral drug as a gastro retentive dosage form. Int. J Res Pharm Chem 2011;1(3):519-527.
16. Kohli S, Sharma M and Dinda A. In-vitro and in-vivo evaluation of repaglinide loaded floating microspheres prepared by different viscosity grades of HPMC polymer. Saudi Pharm J 2015;23:675-682.
17. Ramalingam N, Mohamed JA, Sunusha P, Palanivelu M, Surendiran NS and Ganesan B. Preparation and characterization of floating microspheres of ciprofloxacin hydrochloride. World J Pharm Pharm Sci 2017;6(6):1394-1408.
18. Ramu S, Suresh P, Rao DS and Ramakrishna G. Formulation and evaluation of floating microspheres of rosiglitazone. Int J Pharm Chem Biol Sci 2015;5(4):907-918.
Statistics
6 Views | Downloads
Citations
How to Cite
ARUMUGAM, K., P. D. BORAWAKE, and J. V. SHINDE. “Formulation and Evaluation of Floating Microspheres of Ciprofloxacin by Solvent Evaporation Method Using Different Polymers.”. International Journal of Pharmacy and Pharmaceutical Sciences, Vol. 13, no. 7, June 2021, doi:10.22159/ijpps.2021v13i7.41204.
Section
Original Article(s)