COMPARISON OF PREGABALIN AND NORTRIPTYLINE ON SLEEP, QUALITY OF LIFE IN POSTHERPETIC NEURALGIA : A PROSPECTIVE, RANDOMISED, OPEN LABEL, PARALLEL STUDY

  • KANIKA KHAJURIA GMC jammu
  • SEEMA GUPTA GOVT MEDICAL COLLEGE JAMMU , UT JAMMU &KASHMI, INDIA..
  • DINESH KUMAR GOVT MEDICAL COLLEGE JAMMU , UT JAMMU &KASHMI, INDIA.
  • DEV RAJ DOGRA GOVT MEDICAL COLLEGE JAMMU , UT JAMMU &KASHMIR
  • VIJAY KHAJURIA GOVT MEDICAL COLLEGE JAMMU , UT JAMMU &KASHMIR.

Abstract

ABSTRACT


Introduction- Postherpetic neuralgia (PHN) is a complication of herpes zoster  and severe pain affects sleep and quality of life . Most frequently anticonvulsants ( gabapentin  or pregabalin ) and tricyclic antidepressants (amitriptyline or nortriptyline) are used as systemically in management . Aim of study: was to study and compare effect of  Pregabalin and Nortriptyline  on sleep and  quality of life in patients of PHN.


Materials and methods The present study was conducted in 48  patients of PHN attending  OPD of Dermatology, GMC Jammu , Based on  inclusion/exclusion criteria  patients were randomized into two treatment arms Group A (pregabalin 150mg/day  )and group B ( amitriptyline 25mg /day)  and  were followed up to eight weeks and assessed for  Sleep  (MOS) and quality of life( EQ-5D-5L score)  .Clinicians Global Impression of Change (CGIC )score and Patient Global Impression of Change(PGIC) score were used to evaluate overall clinical improvement.    


Results:  ,Both  drugs significantly improved all parameter(p<0.0001) . However, on comparison pregabalin was found to be better than Nortriptyline at eight weeks on  mean CGIC((p<0.004), PGIC((p<0.0003),  and was  numerically better on MOS and  Mean EQ-5D-5L  .


Conclusion: Both  pregabalin and nortriptyline were equally effective in  improving sleep  and quality of life . Overall clinical improvement was better with pregabalin  than nortriptyline at eight weeks  .


.Key words: Postherpetic neuralgia (PHN), pregabalin , nortriptyline , MOS , CGIC, PGIC and  EQ-5D-5L score  .

Keywords: Postherpetic neuralgia (PHN), pregabalin , nortriptyline , MOS , CGIC, PGIC and EQ-5D-5L score .

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References

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KHAJURIA, K., S. GUPTA, D. KUMAR, D. R. DOGRA, and V. KHAJURIA. “COMPARISON OF PREGABALIN AND NORTRIPTYLINE ON SLEEP, QUALITY OF LIFE IN POSTHERPETIC NEURALGIA : A PROSPECTIVE, RANDOMISED, OPEN LABEL, PARALLEL STUDY”. International Journal of Pharmacy and Pharmaceutical Sciences, Vol. 13, no. 6, Apr. 2021, doi:10.22159/ijpps.2021v13i6.41244.
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