ANTIDIABETIC AND ANTIDYSLIPIDEMIC ACTIVITY OF ETHYL ACETATE FRACTIONS OF XYLOCARPUS GRANATUM AND XYLOCARPUS MOLLUCCENSIS ON HIGH FRUCTOSE HIGH FAT AND HIGH SUCROSE HIGH FAT FED-LOW DOSED STREPTOZOTOCIN TREATED DIABETIC RATS

  • Swayam Prakash Srivastava CSIR-Central Drug Research Institute
  • Akansha Mishra CSIR-Central Drug Research Institute
  • Vijai Lakshmi CSIR-Central Drug Research Institute
  • Akhilesh Kumar Tamrakar CSIR-Central Drug Research Institute
  • Mahendra Nath Srivastava CSIR-Central Drug Research Institute
  • Arvind Kumar Srivastava Senior Principal Scientist & Head, Division of Biochemistry, CSIR-Central Drug Research Institute, Lucknow-226001, India.

Abstract

Objectives: The present study was carried out to investigate the antidiabetic and antidyslipidemic effect of standardized fractions of X. granatum (CDR-134 F194) and X. molluccensis (CDR-267 F018) by measuring the status of blood glucose, serum insulin, lipid levels, hepatic and renal function markers of high fructose high fed streptozotocin treated rats and high sucrose high fat diet fed-low dosed Streptozotocin treated diabetic rats.

Methods: Male rats of Sprague Dawley strain of body weight around 150 g when kept on high fructose high fat diet and high sucrose high fat diet for two weeks, respectively, showed abnormal glucose tolerance, dyslipidemia and obesity and at this stage when streptozotocin was given intraperitoneally at 45.0 mg/kg body weight caused persistent hyperglycemia in them addition to dyslipidemia along with impairment in their hepatic and renal functions.

Results: The standardized fractions of X. granatum (CDR-134 F194) and X. molluccensis (CDR-267F018) when given to these high fructose high fat fed low dosed streptozotocin treated diabetic rats or high sucrose high fat diet fed-low dosed streptozotocin treated diabetic rats for 10 consecutive days showed significant improvement in their glucose intolerance, decline in their serum triglycerides and LDL-cholesterol levels. These CDR-134 F194 and CDR-267 F018 treated rats also showed elevation in their HDL-cholesterol levels and improvement in their hepatic and renal functions as evidenced by decline in SGOT, SGPT, urea, uric acid and creatinine levels.

Conclusion: The present study thus concludes that the antidiabetic efficacy of standardized fractions of X. granatum (CDR-134 F194) and X. molluccensis (CDR-267F018) have favorable effect in bringing down the severity of hyperglycemia, hyperlipidemia, decline the increased level of renal and hepatic function markers and also improving glucose tolerance activity.

Keywords: HFD fed streptozotocin treated diabetic rats, HSD fed streptozotocin treated diabetic rats, Type 2 diabetes mellitus, Antihyperglycaemic activity, Dyslipidaemic activity, Liver function test, Renal function test

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Srivastava, S. P., A. Mishra, V. Lakshmi, A. K. Tamrakar, M. N. Srivastava, and A. K. Srivastava. “ANTIDIABETIC AND ANTIDYSLIPIDEMIC ACTIVITY OF ETHYL ACETATE FRACTIONS OF XYLOCARPUS GRANATUM AND XYLOCARPUS MOLLUCCENSIS ON HIGH FRUCTOSE HIGH FAT AND HIGH SUCROSE HIGH FAT FED-LOW DOSED STREPTOZOTOCIN TREATED DIABETIC RATS”. International Journal of Pharmacy and Pharmaceutical Sciences, Vol. 7, no. 2, 1, pp. 537-43, https://innovareacademics.in/journals/index.php/ijpps/article/view/4970.
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