A SIMPLE AND A CHEAP UV SPECTROPHOTOMETRIC ASSAY METHOD DEVELOPMENT AND VALIDATION OF DABIGATRN ETEXILATE IN CAPSULES


P. Sowndarya, K. Mounika, S. Laxmi Prasanna, K. Sandya, K. Sandya, A. Ashok Kumar

Abstract


Objective: To develop a simple and cheap UV spectrophotometric method for the quantitative estimation of Dabigatrn etexilate (150mg) in capsules and validate as per ICH guidelines.

Method: The optimized method uses 0.05N HCl as a solvent for the estimation of assay of Dabigatrn etexilate in capsules at a wavelength of 325 nm.

Results: The developed method resulted in Dabigatrn etexilate exhibiting linearity in the range 5-15μg/ml. The assay precision is exemplified by relative standard deviation of 1.4%. Percentage Mean recovery was found to be in the range of 98‐102, during accuracy studies.

Conclusion:  A simple and a cheap UV spectrophotometric method was developed and validated for the quantitative estimation of Dabigatrn etexilate in capsules as per ICH guidelines and hence it can be used for the routine analysis in various pharmaceutical industries.

 

 


Keywords


UV, Dabigatrn etexilate, method development, validation

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References


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About this article

Title

A SIMPLE AND A CHEAP UV SPECTROPHOTOMETRIC ASSAY METHOD DEVELOPMENT AND VALIDATION OF DABIGATRN ETEXILATE IN CAPSULES

Keywords

UV, Dabigatrn etexilate, method development, validation

Date

26-06-2015

Additional Links

Manuscript Submission

Journal

International Journal of Pharmacy and Pharmaceutical Sciences
Vol 7, Issue 8, 2015 Page: 282-285

Online ISSN

0975-1491

Statistics

106 Views | 45 Downloads

Authors & Affiliations

P. Sowndarya
Jawaharlal Nehru technological University, Hyderabad (JNTUH)
India

K. Mounika
Jawaharlal Nehru technological University, Hyderabad (JNTUH)
India

S. Laxmi Prasanna
Jawaharlal Nehru technological University, Hyderabad (JNTUH)
India

K. Sandya
Jawaharlal Nehru technological University, Hyderabad (JNTUH)
India

K. Sandya
Jawaharlal Nehru technological University, Hyderabad (JNTUH)
India

A. Ashok Kumar
Department of Pharmaceutical analysis and Quality Assurance, Vijaya college of pharmacy, Munaganur (village), Hayathnagar (mandal), Hyderabad 501511, India
India


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