• Rashmi Sareen Shoolini University Bharat Institution of Technology
  • Varun Bhardwaj Jaypee University of Information Technology
  • Vineet Mehta Kurukshetra University
  • Arun Sharma Shoolini University Jaypee University of Information Technology


Objective: The present study was aimed at the fabrication and characterization of solid lipid based microspheres (SLM) of Ketoprofen (KPF) and comparing its anti-inflammatory potential with the marketed formulation.

Methods: Stearic acid as a lipid and tween 20, 80, span 20 and 80 as surfactants (at various concentrations) were utilized for formulation of topical delivery. Microparticles were successfully fabricated (0.71-3.12 µm) by hot melt microencapsulation technique and were characterised by photomicroscope, FTIR, scanning electron surface morphology, particle size analysis, zeta potential, fluorescent microscopy and In-vitro drug release studies followed by In-vitro and In-vivo anti-inflammatory studies.

Results: Results revealed that tween 80 resulted in exceptional KPF entrapment efficiency of 82.6% with spherical rough surface morphology. In-vitro drug release showed the initial burst release of 47% upto 2h followed by sustained release of 70% for 12h. By employing drug release kinetic modelling, formulations were found to obey Higuchi model and Korsmeyer-Peppas model. Further the In-vitro permeation study of optimized gel formulation represented better drug uptake through rat skin in comparison to marketed product. Finally, SLMs were found to possess superior In-vitro and In-vivo anti-inflammatory potentials when compared to marketed formulation.

Conclusion: SLMs proved to be promising drug carrier system for KPF topical delivery as they possessed the desirable particle size with high ability for drug entrapment with sustained anti-inflammatory effect.


Keywords: Ketoprofen, Solid lipid microsphere, Controlled release, Anti-inflammatory activity


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How to Cite
Sareen, R., V. Bhardwaj, V. Mehta, and A. Sharma. “TOPICAL GEL INCORPORATED WITH NON-IONIC SURFACTANT BASED SOLID LIPID MICROSPHERES OF KETOPROFEN: PHYSICOCHEMICAL ANALYSIS AND ANTI-INFLAMMATORY EVALUATION”. International Journal of Pharmacy and Pharmaceutical Sciences, Vol. 7, no. 11, Aug. 2015, pp. 199-06,
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