BIOACTIVITIES OF THE THAI MEDICINAL AND EDIBLE PLANTS C. CAJAN, M. CITRIFOLIA AND O. AMERICANUM
Objective: Inflammation and oxidative stress are closely related and play a role in various diseases. If an infectious component plays a role, an antibacterial effect is of advantage. Thus, natural remedies which combine different bioactivities have a broader range of application.
Methods: Here we elucidate the anti-inflammatory, antioxidant and antibacterial effects of three edible and traditionally used Thai plants including leaves of Cajanus cajan, Morinda citrifolia and Ocimum americanum.
Results: The extracts exerted significant anti-inflammatory activity in lipopolysaccharide (LPS)-stimulated macrophages. C. cajan extract shows a broad spectrum of antibacterial activity against Gram positive and negative, aerobic and anaerobic bacteria, whereas M. citrifolia and O. americanum possess antibacterial activity only against anaerobic bacteria. Extracts of all three plants showed significant antioxidant effects.
Conclusion: The three plants are potential herbal remedies or supplements for functional food for the treatment and prevention of inflammation, oxidative imbalance, and bacterial infections or associated diseases.
2. Ambekar S, Patil SC, Giri AP, Kachole MS. Proteinaceous inhibitors of trypsin and amylases in developing and germinating seeds of red gram (Cajanus cajan L. Millsp.). J Sci Food Agric 1996;72:57-62.
3. Grover JK, Yadav S, Vats JJ. Medicinal plants of India with anti-diabetic potential. J Ethnopharmacol 2002;81:81-100.
4. Pal D, Mishra P, Sachan N, and Ghosh AK. Biological activities and medicinal properties of Cajanus cajan (L) Millsp. J Adv Pharm Technol Res 2011;2:207-14.
5. Sharma S, Agarwal N, and Verma P. Pigeon pea (Cajanus cajan L.): a hidden treasure of regime nutrition. Environ Exp Bot 2011;1:91-101.
6. Thani W, Vallisuta O, Siripong P, Ruangwises N. Anti-proliferative and antioxidative activities of Thai noni/Yor (Morinda citrifolia Linn.) leaf extract. Southeast Asian J Trop Med Public Health 2010;41:482-9.
7. Chan-Blanco Y, Vaillant F, Perez AM, Reynes M, Brillouet JM, Brat P. The noni fruit (Morinda citrifolia L.): a review of agricultural research, nutritional and therapeutic properties. J Food Comp Anal 2006;19:645-54.
8. Palu A, Su C, Zhou B, Wes tB, Jensen J. Wound healing effects of noni (Morinda citrifolia L.) leaves: a mechanism involving its PDGF/A2A receptor ligand binding and promotion of wound closure. Phytother Res 2010;24:1437-41.
9. Chanwitheesuk A, Teerawutgulrag A, Rakariyatham N. Screening of antioxidant activity and antioxidant compounds of some edible plants of thailand. Food Chem 2005;92:491-7.
10. Thaweboon S, Thaweboon B. In vitro antimicrobial activity of Ocimum americanum L. essential oil against oral microorganisms. Southeast Asian J Trop Med Public Health 2009;40:1025-33.
11. Seyoum A, Killeen G, Kabiru E, Knols B, Hassanali A. Field efficacy of thermally expelled or live potted repellent plants against african malaria vectors in western kenya. Trop Med Int Health 2013;8:1005-11.
12. Aluko B, Oloyed eO, Afolayan A. Polyphenolic contents and free radical scavenging potential of extracts from leaves of Ocimum americanum L. Pak J Biol Sci 2013;16:22-30.
13. Kurian A, Sanka MA. Medicinal Plants. New Delhi: New India publishing agency; 2007. p. 240.
14. Wei Z, Jin S, Luo M, Pan Y, Li T, Qi X, et al. Variation in contents of main active components and antioxidant activity in leaves of different pigeon pea cultivars during growth. J Agric Food Chem 2013;61:2-9.
15. Zu Y-G, Liu X-L, Fu Y-J, Wu N, Kong Y, Wink M. Chemical composition of the SFE-CO2 extracts from Cajanus cajan (L.) Huth and their antimicrobial activity in vitro and in vivo. Phytomedicine 2010;17:1095-101.
16. Lai YS, Hsu WH, Huang JJ, Wu SC. Antioxidant and anti-inflammatory effects of pigeon pea (Cajanus cajan L.) extracts on hydrogen peroxide-and lipopolysaccharide-treated RAW264.7 macrophages. Food Funct 2012;3:1294â€“301.
17. Serafini MR, Santos RC, Guimaraes AG, Santos JPA, Santos ADC, Alves IA, et al. Morinda citrifolia linn leaf extract possesses antioxidant activities and reduces nociceptive behavior and leukocyte migration. J Med Food 2011;14:1159-66.
18. Okonogi S, Duangrat C, Anuchpreeda S, Tachakittirungrod S, Chowwanapoonpohn S. Comparison of antioxidant capacities and cytotoxicities of certain fruit peels. Food Chem 2007;103:839-46.
19. Tachakittirungrod S, Okonogi S, Chowwanapoonpohn S. Study on antioxidant activity of certain plants in Thailand: Mechanism of antioxidant action of guava leaf extract. Food Chem 2007;103:381-8.
20. Mueller M, Hobiger S, Jungbauer A. Anti-inflammatory activity of extracts from fruits, herbs and spices. Food Chem 2010;122:987-96.
21. Liu X, Zhang X, Fu Y, Zu Y, Wu N, Liang L, et al. Cajanol inhibits the growth of Escherichia coli and Staphylococcus aureus by acting on membrane and DNA damage. Planta Med 2011;77:158-63.
22. Zaidan M, Noor Rain A, Badrul A, Adlin A, Norazah A, Zakiah I. In vitro screening of five local medicinal plants for antibacterial activity using disc diffusion method. Trop Biomed 2005;22:165-70.
23. Cimanga K, Kambu K, Tona L, Apers S, De Bruyne T, Hermans N, et al. Correlation between chemical composition and antibacterial activity of essential oils of some aromatic medicinal plants growing in the democratic republic of congo. J Ethnopharmacol 2002;79:213-20.
24. Wu N, Fu K, Fu Y, Zu Y, Chang F, Chen Y, et al. Antioxidant activities of extracts and main components of Pigeonpea [Cajanus cajan (L.) Millsp.] leaves. Molecules 2009;14:1032-43.
25. Patel NK, Bhutani KK. Pinostrobin and cajanus lactone isolated from cajanus cajan (L.) leaves inhibits TNF-Î± and IL-1Î² production: in vitro and in vivo experimentation. Phytomedicine 2014;21:946-53.
26. Dussossoya E, Brat P, Bony E, Boudard F, Poucheret P, Mertz C, Giaimis J, et al. Characterization, anti-oxidative and anti-inflammatory effects of costa rican noni juice (Morinda citrifolia L.). J Ethnopharmacol 2011;133:108-15.