FORMULATION DEVELOPMENT AND EVALUATION OF SUSTAINED RELEASE IBUPROFEN TABLETS WITH ACRYLIC POLYMERS (EUDRAGIT) AND HPMC

  • Ranjit Prasad Swain Maharajah’s College of Pharmacy, Phool Bagh, Vizianagaram 535002, Andhra Pradesh, India
  • T. Ratna Kumari Maharajah’s College of Pharmacy, Phool Bagh, Vizianagaram
  • Satyajit Panda Maharajah’s College of Pharmacy, Phool Bagh, Vizianagaram

Abstract

Objective: An attempt was made to develop sustained release matrix tablets of ibuprofen using HPMC (K4M, K15M & K100M) and eudragit (RS 100 & RL 100) as release retardant polymers.

Methods: The ibuprofen matrix tablets were prepared by direct compression method using lactose as a diluent. Nineteen formulations of different polymer percentages were formulated, (F1-F19 with 7.5%, 10%, 15%, 20%, 25%, 30% w/w).

Results: The formulations were optimized on the basis of acceptable weight variation, thickness, hardness, % friability, % drug content and in vitro drug release. The in vitro release studies were performed using USP type II apparatus using 7.2 pH phosphate buffer as a dissolution medium, showed that optimized formulation F8 consisting of eudragit RL with 20% of the polymer was found to sustain the release of ibuprofen over a period of 12 h. The formulation exhibited highest correlation (R) value in case of Hixson-Crowell model and the release kinetic study proved that the formulation showed erosion process, and shown to follow zero order kinetics.

Conclusion: It was concluded that eudragit RL can be used for the preparation of sustained release tablet of ibuprofen.

 

Keywords: Ibuprofen, Eudragit, HPMC, Sustained release

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How to Cite
Swain, R. P., T. R. Kumari, and S. Panda. “FORMULATION DEVELOPMENT AND EVALUATION OF SUSTAINED RELEASE IBUPROFEN TABLETS WITH ACRYLIC POLYMERS (EUDRAGIT) AND HPMC”. International Journal of Pharmacy and Pharmaceutical Sciences, Vol. 8, no. 2, Feb. 2016, pp. 131-5, https://innovareacademics.in/journals/index.php/ijpps/article/view/9523.
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