• Harish Thanusubramanian
  • Bharti Chogtu
  • Rahul Magazine


A 43-year-old patient was diagnosed of left sided empyema. He was started on injectable piperacillin-tazobactam combination and clindamycin.
After 11 days, he developed itchy red lesions over different parts of the body. Both the drugs were immediately stopped in view of drug allergy.
However, oral clindamycin with a lower dose was restarted, and patient tolerated the drug without any skin related episodes. Postdischarge he was
prescribed oral clindamycin for 2 more weeks. 2 days postdischarge he started developing rash. The patient continued the drug for next 10 days
and as a severity of rashes increased he reported to the hospital. He had itchy red lesions throughout the body. Clindamycin was stopped, and he
was prescribed clonate lotion and tablet cetirizine for 10 days. The lesions resolved. A patient was informed that he is allergic to beta-lactams and
Keywords: Clindamycin, Skin rashes, Beta-lactams.


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Nakamura Y, Watamatsu K, Muto M. Drug-induced hypersensitivity

syndrome induced by clindamycin. Acta Derm Venereol 2013;93(1):83-4.

Tian D, Mohan RJ, Stallings G. Drug rash with eosinophilia and

systemic symptoms syndrome associated with clindamycin. Am J Med


Miller Quidley A, Bookstaver PB, Gainey AB, Gainey MD.

Fatal clindamycin-induced drug rash with eosinophilia and

systemic symptoms (DRESS) syndrome. Pharmacotherapy


Pereira N, Canelas MM, Santiago F, Brites MM, Gonçalo M. Value of

patch tests in clindamycin-related drug eruptions. Contact Dermatitis


Seitz CS, Bröcker EB, Trautmann A. Allergy diagnostic testing

in clindamycin-induced skin reactions. Int Arch Allergy Immunol


Kapoor R, Flynn C, Heald PW, Kapoor JR. Acute generalized

exanthematous pustulosis induced by clindamycin. Arch Dermatol


Schwab RA, Vogel PS, Warschaw KE. Clindamycin-induced acute

generalized exanthematous pustulosis. Cutis 2000;65(6):391-3.

Valois M, Phillips EJ, Shear NH, Knowles SR. Clindamycin-associated

acute generalized exanthematous pustulosis. Contact Dermatitis


Sulewski RJ Jr, Blyumin M, Kerdel FA. Acute generalized

exanthematous pustulosis due to clindamycin. Dermatol Online J


Mazur N, Greenberger PA, Regalado J. Clindamycin hypersensitivity

appears to be rare. Ann Allergy Asthma Immunol 1999;82(5):443-5.

The use of the WHO-UMC System for Standardized Case Causality

Assessment. Available from:

pdf. [Last cited on 2015 Mar 20].



How to Cite

Thanusubramanian, H., B. Chogtu, and R. Magazine. “ADVERSE REACTION DUE TO CLINDAMYCIN”. Asian Journal of Pharmaceutical and Clinical Research, vol. 9, no. 2, Mar. 2016, pp. 8-9,



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