Sertraline induced hyponatremia

H Dhananjay Bhat, Harish Thanusubramanian, Balaji O


A 53 year old female patient with a history of carcinoma of the breast in remission and dilated cardiomyopathy on treatment was newly diagnosed with depression. She was started on Sertraline 50mg once a day. 2 days later she developed severe hyponatremia (serum sodium 114mEq/l). Her condition further deteriorated and on the 6th day her medication was stopped and replaced with mirtazapine. Osmolality studies she was diagnosed with SIADH (Syndrome of Inappropriate Antidiuretic Hormone secretion). She was treated with IV sodium chloride for her hyponatremia. At discharge serum sodium levels improved (127mEq/l)  and subsequent follow up 4 weeks later showed normal sodium values (138mEq/L)

Keywords: Sodium chloride, Syndrome of inappropriate antidiuretic hormone, Serum sodium, Serum osmolarity.

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Sertraline induced hyponatremia





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Asian Journal of Pharmaceutical and Clinical Research
Vol 10 Issue 4 April 2017 Page: 1-2

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H Dhananjay Bhat
Senior Resident, Kasturba Medical College, Udupi District, Manipal-576104

Harish Thanusubramanian
Postgraduate, Kasturba Medical College, Udupi District, Manipal-576104

Balaji O
Postgraduate, Kasturba Medical College, Udupi District, Manipal-576104

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