• Siva Prasad Panda Jadavpur University
  • Pallab Kanti Haldar
  • Sudipta Das


Objective: This research investigated in vitro hypoglycemic and antimicrobial activity of methanolic fruit extract of Cucumis callosus (MECC) (Rottl.)
Methods: The in vitro antidiabetic ability of MECC was evaluated by inhibition studies of the digestive enzymes including α-amylase and α-glycosidase.
The antimicrobial activity of extract was further evaluated against 21 laboratory strains belongs to 8 bacterial species and 4 fungal species using cupplate
diffusion assay
and agar
dilution assay.
Results: Our assay result suggested that the MECC exhibited dose-dependent increase in percentage inhibitory activity on α-glycosidase
405.37 µg/ml) and α-amylase enzymes (IC
721.55 µg/ml). The results of antimicrobial activity also showed that the extract inhibited the growth
of 13 strains of 7 bacterial species and all fungal species.
Conclusion: The observed inhibitions of α-amylase and α-glycosidase and inhibition of some microbial species suggested that the MECC may be useful
in the management of diabetes mellitus and treatment of some infectious diseases.
Keywords: Cucumis callosus, Diabetes, α-amylase, α-glycosidase, Antimicrobial.

Author Biography

Siva Prasad Panda, Jadavpur University
research scholar, dept. of Pharm Tech., Jadavpur University


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S. aureus ML 314 G+ 13 16 34 38
S. aureus ML 264 G+ 13 15 21 28
S. aureus ML 267 G+ 12 12 30 34
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B. pumilus 8241 G+ 8 11 17 26
B. cereus PI 11778 G+ 10 12 14 20
V. cholerae 117 G− 12 13 24 32
K. pneumoniae 114 G− 12 14 27 30
E. coli DH 5α G− 10 11 34 38
S. dysenteriae 7 G− 13 15 24 30
S. boydi RC G− 18 20 33 34
S. typhimurium 74 G− 10 12 17 30
C. albicans MTCC 183 10 16 34
A. flavus MTCC 1973 15 17 30
A. niger MTCC 16404 15 16 30
C. albidus MTCC 183 17 18 28
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How to Cite
Panda, S. P., P. Kanti Haldar, and S. Das. “IN VITRO HYPOGLYCEMIC AND ANTIMICROBIAL ACTIVITY OF CUCUMIS CALLOSUS (ROTTL.) COGN. FRUIT”. Asian Journal of Pharmaceutical and Clinical Research, Vol. 9, no. 8, Oct. 2016, pp. 77-81, doi:10.22159/ajpcr.2016.v9s2.11687.
Original Article(s)