EVALUATION OF ANTIOXIDANT AND ANTIULCER ACTIVITY OF METHANOLIC EXTRACT OF GARDENIA GUMMIFERA L. IN RATS
Objective: The aim was to assess the effect of anti ulcer and anti oxidant activity of methanolic extract of Gardenia Gummifera (MEGG) whole plant in
ulcer induced rats and in-vitro anti oxidants method respectively.
Methods: In the present study, the efficacy of an MEGG was evaluated against aspirin-induced ulcers in rats. G. gummifera at doses of 150 mg/kg and
300 mg/kg was administered orally once daily for 6 days.
Results: Results showed that extract treatments prevented ulcer area and gastric secretion in a dose-dependent manner. Administration of 2000 mg/kg
extract did not show any toxicity in albino mice. In preliminary phytochemical studies identified the presence of flavonoids in the MEGG.
Conclusion: According to the results, it was concluded that the whole plant of G. gummifera has significant antiulcer activity due to the presence of
potent antioxidants like flavonoids.
Keywords: Aspirin, Antiulcer, Hydrogen peroxide, Gardenia gummifera.
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Fig. 2: Effect of methanolic extract of Gardenia gummifera (MEGG) on aspirin-induced ulcers, (a) Normal control, (b) diseased control, (c) MEGG 150 mg/kg, (d) MEGG 300 mg/kg, (e) standard control (ranitidine 50 mg/kg)
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