EVALUATION OF ANTIOXIDANT AND ANTIULCER ACTIVITY OF METHANOLIC EXTRACT OF GARDENIA GUMMIFERA L. IN RATS

  • Pradeep Kumar Sabbani SWAMI VIVEKANANDA INSTITUTE OF PHARMACEUTICAL SCIENCES
  • Pavan Kumar Chityala
  • Gowrishankar Nl
  • Naveen Kumar
  • Shilpa K

Abstract

ABSTRACT
Objective: The aim was to assess the effect of anti ulcer and anti oxidant activity of methanolic extract of Gardenia Gummifera (MEGG) whole plant in
ulcer induced rats and in-vitro anti oxidants method respectively.
Methods: In the present study, the efficacy of an MEGG was evaluated against aspirin-induced ulcers in rats. G. gummifera at doses of 150 mg/kg and
300 mg/kg was administered orally once daily for 6 days.
Results: Results showed that extract treatments prevented ulcer area and gastric secretion in a dose-dependent manner. Administration of 2000 mg/kg
extract did not show any toxicity in albino mice. In preliminary phytochemical studies identified the presence of flavonoids in the MEGG.
Conclusion: According to the results, it was concluded that the whole plant of G. gummifera has significant antiulcer activity due to the presence of
potent antioxidants like flavonoids.
Keywords: Aspirin, Antiulcer, Hydrogen peroxide, Gardenia gummifera.

References

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Fig. 2: Effect of methanolic extract of Gardenia gummifera (MEGG) on aspirin-induced ulcers, (a) Normal control, (b) diseased control, (c) MEGG 150 mg/kg, (d) MEGG 300 mg/kg, (e) standard control (ranitidine 50 mg/kg)
d
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How to Cite
Sabbani, P. K., P. Kumar Chityala, G. Nl, N. Kumar, and S. K. “EVALUATION OF ANTIOXIDANT AND ANTIULCER ACTIVITY OF METHANOLIC EXTRACT OF GARDENIA GUMMIFERA L. IN RATS”. Asian Journal of Pharmaceutical and Clinical Research, Vol. 8, no. 4, July 2015, pp. 41-44, https://innovareacademics.in/journals/index.php/ajpcr/article/view/1311.
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