A CORRELATIVE STUDY ON SPINDLE CELL SARCOMA WITH CYTO-HISTOLOGICAL GRADING BY CONVENTIONAL METHODS IN AN INDIAN TERTIARY CARE TEACHING HOSPITAL


Sima Chauhan, Niranjan Sahu, Mahesh Chandra Sahu, Jagadish Hansa, Kanaklata Das, Ajit Kumar Dash

Abstract


Objective: Spindle cell sarcomas constitute an important component of soft tissue sarcomas, where accurate grading is more important than histologic subtypes to plan treatment strategies and determine prognosis. To assess whether histologic criteria for grading sarcomas could be applied to fine needle aspiration biopsy (FNAB) specimens of adult spindle cell sarcomas without knowledge of sarcoma subtypes. Furthermore, correlate this grading with histologic Federation Nationale Des Centres de lutte contre le cancer (FNCLCC) grading system and find out the percentage of accuracy of FNAB grading.

Methods: Hundred cases were studied by fine needle aspiration cytology (FNAC), among them 50 cases found to be spindle cell sarcoma; in only 42 cases surgical specimens were available. Each aspiration being spread into two or more slides. Subsequently, biopsy was done and studied. Technique used - grading of FNAB specimens and corresponding surgical specimens.

Result: Grading of FNAB specimens done taking into account four parameters - nuclear atypia, nuclear variation (nuclear contour, chromatin, nucleoli, and nuclear overlap), mitotic figure, and necrosis. Grading of surgical specimens done by FNCLCC system. The overall results were correlated for both FNAC and biopsy concordance and statistically analyzed. From there the sensitivity and specificity were calculated as 95.23% and 80.76%, respectively.

Conclusion: Histologic criteria for grading sarcomas in adults could be applied to FNAC specimens of spindle cell sarcomas with 88% accuracy. While comparing the diagnosis given by FNAC and biopsy, it revealed the true positive were 40 cases, true negative 42 cases, false positive 10 cases, and false negative (FN) 2 cases.

 


Keywords


Spindle cell sarcoma, Fine needle aspiration biopsy (Fine needle aspiration cytology), Biopsy, Sensitivity, Specificity.

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About this article

Title

A CORRELATIVE STUDY ON SPINDLE CELL SARCOMA WITH CYTO-HISTOLOGICAL GRADING BY CONVENTIONAL METHODS IN AN INDIAN TERTIARY CARE TEACHING HOSPITAL

Keywords

Spindle cell sarcoma, Fine needle aspiration biopsy (Fine needle aspiration cytology), Biopsy, Sensitivity, Specificity.

DOI

10.22159/ajpcr.2017.v10i6.17896

Date

01-06-2017

Additional Links

Manuscript Submission

Journal

Asian Journal of Pharmaceutical and Clinical Research
Vol 10 Issue 6 June 2017 Page: 267-272

Print ISSN

0974-2441

Online ISSN

2455-3891

Statistics

173 Views | 126 Downloads

Authors & Affiliations

Sima Chauhan
Department of Pathology, IMS & SUM Hospital, Siksha O Anusandhan University, K8, Kalinga Nagar, Bhubaneswar - 751 003, Odisha, India.
India

Niranjan Sahu
Department of Radiology, IMS & SUM Hospital, Siksha O Anusandhan University, K8, Kalinga Nagar, Bhubaneswar - 751 003, Odisha,
India

Mahesh Chandra Sahu
Directorate of Medical Research, IMS & SUM Hospital, Siksha O Anusandhan University, K8, Kalinga Nagar, Bhubaneswar - 751 003
India

Jagadish Hansa
Directorate of Medical Research, IMS & SUM Hospital, Siksha O Anusandhan University, K8, Kalinga Nagar, Bhubaneswar - 751 003, Odisha, India.
India

Kanaklata Das
Department of Pathology, KIIMS Hospital, Odisha, India.
India

Ajit Kumar Dash
Department of Pathology, SCB Medical College, Odisha, India.
India


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